Item | Information |
---|---|
CAS RN | 10025-73-7 |
Chemical Name | Chromium(III) chloride |
Substance ID | 25B0046 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Not classified |
- |
- | - | Not combustible (ICSC (2004)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible (ICSC (2004)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (ICSC (2004)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From information on water solubility: slightly soluble in hot water (HSDB (Access on September 2013)), it is recognized that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing chlorine (but not oxygen), but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, no tests in which this substance was specified were conducted, and there are negative results in many of the epidemiological surveys or tests on exposure to trivalent chromium (EHC 61 (1988), ATSDR (2012), PATTY (6th, 2012)). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Respiratory sensitization | Category 1 |
Danger |
H334 |
P304+P340
P342+P311 P261 P284 P501 |
The Japan Society for Occupational Health (JSOH) classified chromium as occupational sensitizers to the airway Group 2 (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013)). This substance was not specified in this classification, but it was thought that chromium compounds were included. Therefore, this substance, a chromium compound, was also thought to cause respiratory sensitization, and it was classified in Category 1. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
The Japan Society for Occupational Health (JSOH) classified chromium as occupational skin sensitizers Group 1 (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013)). This substance was not specified in this classification, but it was thought that chromium compounds were included. Therefore, this substance, a chromium compound, was also thought to cause skin sensitization, and it was classified in Category 1. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (ATSDR (2012), CICAD 76 (2009)) and negative in a DNA damage test (alkaline elution method) with rat kidney (CICAD 76 (2009)). As for in vitro, many bacterial reverse mutation tests were negative, and negative and positive results were mixed in chromosomal aberration tests with cultured mammalian cells and human lymphocytes (CICAD 76 (2009), IARC (1999), ATSDR (2012)). And it was negative in a gene mutation test with cultured cells (CICAD 76 (2009), ATSDR (2012)) and positive in a micronucleus test with cultured human cells (CICAD 76 (2009)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in A4 (as chromium metal and Cr (III) compound) in ACGIH (1994), D (as chromium (III), insoluble salts) in EPA (1998), and Group 3 (as chromium (III)) in IARC (1990). The category was changed according to the GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, in a test in which male rats were orally dosed (drinking water) and effects on male fertility and copulation behavior were investigated, decreases in body weight, absolute testis weight, the absolute and relative weight of the seminal vesicle, and the absolute and relative weight of the preputial gland were observed in males, and as for copulation behavior, an increase in the post-ejaculation latency, a decrease in the number of males ejaculating, and decreased aggressivity were found (CICAD 76 (2009), ATSDR (2012)). However, it is reported that no effects on the number of pregnant females, the number of implantations, and the number of viable fetuses were seen. There is no information on developmental toxicity. Therefore, it was classified as "Classification not possible" due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
It was classified in Category 3 from 24-hour EC50 = 22 mg-Cr/L (equivalent to 67 mg-CrCl3/L) for crustacea (Daphnia magna) (CICADs 76, 2009). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 |
- |
H412 |
P273
P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC = 0.7 mg-Cr/L (equivalent to 2.1 mg-CrCl3/L) for crustacea (Daphnia magna) (CICADs 76, 2009; Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010)), despite unknown behavior of the metal compound, this substance in water. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to 96-hour LC50 = 31.5 mg/L (equivalent to 96 mg-CrCl3/L) for fish (Fundulus heteroclitus) (CICADs 76, 2009), despite unknown behavior of the metal compound, this substance in water. By drawing a comparison between the above results, it was classified in Category 3. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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