NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	1185-55-3
Chemical Name	Trimethoxy(methyl)silane
Substance ID	25A0014
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 9 deg C (test method: unknown) and a boiling point of 102.5 deg C (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)).
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	No data available.
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on a report of an LD50 value of > 9,500 mg/kg (OECD TG 401) for rats (SIDS (2011)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on a report on an LC50 value (6 hours) of > 7,605 ppm (converted 4-hour equivalent value: 9,314 ppm) (OECD TG 403) for rats (SIDS (2011)). Besides, because the value is lower than 90% of the saturated vapour pressure concentration (44,211 ppm), a reference value in the unit of ppm was applied as a vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (Category 3 in UN GHS classification) because it is reported that there was slight irritation in a test in which this substance was applied to rabbits and a score was 0.66 (SIDS (2011)).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was classified in Category 2B because it was assessed to be a slight irritant in an eye irritation test with rabbits (equivalent to OECD TG 405) (SIDS (2011)).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2011)). As for in vitro, it was negative in a bacterial reverse mutation test, and positive in a mouse lymphoma test and a chromosomal aberration test with cultured mammalian cells (SIDS (2011)). In SIDS (2011), there is no judgment on whether this substance is mutagenic.
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG422) with rats in the oral route, no effects on general toxicity, reproductive toxicity, and developmental toxicity were observed (SIDS (2011)). However, because it is a screening test, and there is no sufficient information on developmental toxicity, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Because reversible depression and ataxia were observed after gavage administration to rats (SIDS (2011)), it was classified in Category 3 (narcotic effects). Furthermore, in inhalation exposure (42 mg/L) in rats, urinary bladder calculi, kidney foci, enlarged kidney, and abscessed prostate were found (SIDS (2011)), but these were not adopted as evidence for target organs because they were findings outside the guidance value range.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, thyroid)	Warning	H373	P260 P314 P501	It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG422) with rats by 28-day gavage administration, effects on the liver (weight increase (males and females), centrilobular hepatocellular hypertrophy, periportal vacuolation (females)) and thyroid follicular cell hyperplasia/hypertrophy (males and females) were observed at the dose (250 mg/kg/day: (converted guidance value: 77.8 mg/kg/day)) within the guidance value range for Category 2 (SIDS (2011)). Therefore, it was classified in Category 2 (liver, thyroid). Besides, in a 90-day inhalation test in which rats were exposed to the vapour of this substance, no effects were seen within the guidance value range, but effects on the urinary bladder (calculi, epithelial hyperplasia) were observed at the high concentration (2.2 mg/L) corresponding to "Not classified" (SIDS (2011)).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	From 72-hour ErC50 > 120 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2011), 48-hour LC50 > 122 mg/L for crustacea (Daphnia magna) (SIDS, 2011), and 96-hour LC50 > 110 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2011), it was classified as "Not classified."
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. Because it corresponds to "Not classified" in acute toxicity for all of algae, crustacea, and fish, and it is not water-insoluble (water solubility = 325000 mg/L (SRC, 2013)), it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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