Item | Information |
---|---|
CAS RN | 122-40-7 |
Chemical Name | Amylcinnamaldehyde |
Substance ID | 24A6097 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 113 deg C [closed-cup] (MSDS (Sigma-Aldrich 2012)) above 93 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There are no chemical groups associated with explosive properties, but a chemical group associated with self-reactive properties (acryloyl group) present in the molecule, however, there are no data. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,730 mg/kg for rats (USEPA/HPV (2005), corresponding to List 1). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that there were no deaths after administration of 2,000 mg/kg bw to rabbits, and an LD50 value was > 2,000 mg/kg (USEPA/HPV (2005)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (normal temperatures) (At 1013 mbar/20 deg C: liquid (GESTIS (Access on Aug. 2012))) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
It was classified in Category 2 because it is described that it is a severe skin irritant in humans (HSDB (2012)), and there is a report on List 3 knowledge that it was severely irritating in a Draize test in which 100 mg was applied to the rabbit skin for 24 hours (RTECS (2011)). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It was classified in Category 1 because it is listed as a contact allergen in Contact Dermatitis (Frosch) (5th, 2011) (corresponding to List 1). Besides, this substance was given Sh as a sensitizer in DFG classification in Germany (MAK/BAT (2011)). And as for humans, allergic reactions often occurred after the use of a cream containing this substance and alpha-amylcinnamic alcohol, and chronic recalcitrant eczema was observed in markedly sensitive cases among people who reacted to this substance (HSDB (2012)). |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that it was negative in an in vivo micronucleus test with mouse bone marrow (in vivo somatic cell mutagenicity test) (USEPA/HPV (2005)). Besides, as for in vitro tests, there is a report on a negative result in an Ames test (USEPA/HPV (2005)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Because there were no deaths or evidence of toxicity after dermal administration of 2,000 mg/kg bw to rabbits (USEPA/HPV (2005)), it corresponds to "Not classified" in the dermal route. And only depression and porphyrin-like deposits around the eye and nose are described as findings in an oral administration test with rats, and an LD50 value was reported to be 3,730 mg/kg (USEPA/HPV (2005)), but the details are unknown. Furthermore, because of no data in inhalation administration, it was classified as "Classification not possible" for specific target organ toxicity (single exposure). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a 14-week diet administration toxicity test with rats, liver and kidney weights increased in the high dose group at 4,000 ppm (males 287.3 mg/kg, females 320.3 mg/kg), but these were not associated with related histopathological changes, and no differences from the control group were seen in food consumption, hematological measurements, serum analyses, urine tests, and other test items (USEPA/HPV (2005)). From the results, the high dose of 4,000 ppm where effects were found exceeded the guidance value range, therefore it corresponds to "Not classified" in the oral route. However, because effects in the other routes (inhalation, dermal) are unknown due to no data, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.28 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (readily biodegradable, BOD 51% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and 21-day NOEC = 0.014 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (readily biodegradable, BOD: 51% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and 96-hour LC50 = 0.91 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). From the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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