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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	97-85-8
Chemical Name	Isobutyl isobutyrate
Substance ID	24A6038
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It corresponds to Category 3 from a flash point of 37 deg C [closed-cup] (GESTIS (Access on June 2012)) >= 23 deg C and <= 60 deg C. Besides, it is classified in Class 3, PG III (UN2528) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 432 deg C (CRC (91st, 2010)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on a report on an LD50 value of > 6,400 mg/kg for rats (SIDS (2005)). Besides, as for health hazards, also refer to isobutyl alcohol (CAS RN 78-83-1) and 2-methylpropanoic acid (CAS RN 79-31-2), both of which are metabolites.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on a report on an LD50 value of > 10 mL/kg for rabbits (8,542 mg/kg) (SIDS (2005)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	In a 6-hour exposure test with rats, there was no death in three animals at 658 ppm, which was lower than 90% of the saturated vapour pressure concentration (5697 ppm = 32 mg/L) (SIDS (2005)), and LC50 was estimated to be 658 ppm (converted 4-hour equivalent value 806 ppm) or above, but the category cannot be determined. Therefore, the classification is not possible. And it is reported that two out of three animals died at 31.94 mg/L (converted 4-hour equivalent value 39 mg/L), which was above 90% of the saturated vapour pressure concentration (5697 ppm = 32 mg/L) (SIDS (2005)). From the result, although it may correspond to "Not classified," it was classified as "Classification not possible." because the solid LC50 value was not obtained.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 3 in UN GHS classification) because it is reported that it was a slight irritant in a test by a 24-hour occlusive application of undiluted this substance to the skin of guinea pigs (SIDS (2005)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (2005)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available. Besides, for isobutyl alcohol, the related substance, no findings to be evidence of reproductive toxicity or developmental toxicity were obtained in a two-generation reproductive test by inhalation exposure in rats and developmental toxicity tests by inhalation exposure in pregnant rats and pregnant rabbits during the organogenesis period (SIDS (2005)).
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (narcotic effects) because weakness and ataxia were observed after oral administration of 12,800 mg/kg to rats (SIDS (2005)), and prostration and narcosis were found after inhalation exposure to 5423 ppm/6 hours (converted 4-hour equivalent value: 6,651 ppm = 39 mg/L) in rats (SIDS (2005)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is reported that no treatment-related effects were observed in an 18-week repeated oral administration test with rats, and the NOAEL was 1,000 mg/kg/day above the guidance value range (SIDS (2005)). Therefore, it can be classified as "Not classified" in the oral route. However, because effects in the other routes (inhalation, dermal) are unknown due to no data, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 55.8-59.3 mg/L for crustacea (Daphnia magna) (SIDS, 2005).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 because appropriate data on rapid degradability were not obtained, and it corresponds to Category 3 in acute toxicity for crustacea (SIDS, 2005).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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