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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	4253-34-3
Chemical Name	Methylsilanetriyl triacetate
Substance ID	24A6035
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	There are data on a flash point: 84 deg C (closed-cup) (MSDS (Sigma-Aldrich) (Access on June 2012)), the classification is not possible due to no data in the prescribed test.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is a compound containing a metalloid (Si), and it is described that it reacts rapidly with water and is hydrolyzed to acetic acid and trisilanols (SIAP (2005)). However, because it does not emit flammable gases, it was classified as "Not classified."
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on an LD50 value of 1,602 mg/kg for rats (OECD TG401) (SIDS (2005)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a skin irritation test in which six rabbits were given a 4-hour semi-occlusive application of 0.5 mL of this substance (OECD TG 404, GLP), severe lesions were observed 72 hours after the application, and all the animals showed no noticeable recovery on day 14. The primary dermal irritation index was 4.17, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1. Besides, in the test, 3-minute exposure also caused erythema and edema, the dermal irritation index was 2.94, and irritation was found (SIDS (2005)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In a test in which 0.1 mL of undiluted this substance was applied to nine rabbits (eyes of three of them were washed 20-30 seconds after the application) (GLP-compliant), it caused severe injury within 24 hours characterized by complete opacification of the cornea, the iris being barely visible, the lids being almost closed, and severe erythema and edema in the conjunctiva. The lesion persisted for six days, accompanied by hemorrhage and purulence on day 7, and it was assessed as highly corrosive (SIDS (2005)). It was classified in Category 1 based on the above results.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on negative results in an Ames test (SIDS (2005)) and a chromosomal aberration test with CHO cells (SIDS (2005)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 2 (systemic toxicity)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an acute oral toxicity test with rats (OECD TG 401, GLP) (doses: 800, 1300, 1450, 1600, 1750, 2000 mg/kg bw), an LD50 value was 1602 mg/kg, and clinical signs found were labored breathing, rales, red stains around the snout and extremities, salivation, lacrimation, lethargy, irregular gait, hunched posture, red urination, black/brown anogenital staining, paleness, chromodacryorrhea, and hypothermia. The principal necropsy findings involved the stomach and were stomach adhesions, thickened stomach walls, and abnormal stomach contents, which were considered to be due to corrosion of the mucosa (SIDS (2005)). From the above report, test doses were within the guidance value range for Category 2, but the target organ could not be specified. Therefore, it was classified in Category 2 (systemic toxicity).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	The substance was classified as "Not classified" from 48-hour EC50 = 6000 mg/L for crustacea (Daphnia magna) for acetic acid (pH adjustment), the hydrolysis product (SIDS, 2006).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. For acetic acid (pH adjustment), the hydrolysis product, it is not water-insoluble (water solubility: 243000 mg/L, PHYSPROP Database, 2009), and it corresponds to "Not classified" in acute toxicity for crustacea (SIDS, 2006), therefore the substance was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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