GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 4067-16-7 |
| Chemical name | Pentaethylenehexamine |
| Substance ID | 23A5180 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Not classified | - | - | - | A flash point of 166 degrees C [closed cup] (Dictionary of Organic Compounds (1985)) is above 93 degrees C. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 360 degrees C (NITE Chemical Risk Information Platform (Merck reagent catalog Chem DAT) Access on Nov. 2011). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
From an LD50 value of 1600 mg/kg for rats (Reproductive test, METI (Access on Nov. 2011), equivalent to List 2), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
Lack of data. Besides, it is regarded as corrosive to eyes, skin, and respiratory tract (Reproductive test, METI (Access on Nov. 2011)) but details are unknown. It is classified in R34 in EU classification (EC-JRC (ESIS) (Access on No. 2011)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
Lack of data. Besides, it is regarded as corrosive to eyes, skin, and respiratory tract (Reproductive test, METI (Access on Nov. 2011)) but details are unknown. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - |
No data. Besides, it is classified in R43 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test reported a negative as an in vitro test (NTP DB ID449184 (1982)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
As a result of an oral administration combined repeated dose toxicity study with reproductive/developmental toxicity test in rats (OECD TG422), deteriorated general condition or a marked decrease in body weights, abnormal nursing behaviors, deaths of maternal animals or all pups born at the highest dose of 400 mg/kg were observed. But a significant difference from the control group in sex cycle, copulation index, fertility index, the length of gestation, numbers of corpora lutea and implantation, implantation index, birth index, and delivery index were not shown. (Reproductive test, METI (Access on Nov. 2011)). Child animals showed a low number of alive pups and a low survival rate of 4 days after birth in the highest-dose group. But they were not used as bases for classification because it is explained that they were considered to be effects associated with deteriorated general condition of maternal animals. There were no other dose-related effects on numbers of pups born and alive pups born, a sex ratio, a birth rate, an external test, and necropsy (Reproductive test, METI (Access on Nov. 2011)). Accordingly, the test did not find adverse effects on sexual function and fertility. But it was classified as "Classification not possible" due to lacking data on adverse effects on development of the offspring including teratogenicity. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney) |  |
H373 |
P260 P314 P501 |
As a result of an oral administration combined repeated dose toxicity study with reproductive/developmental toxicity test in rats (doses: 25, 100, 400 mg/kg/day; OECD TG422), dead males and females at 400 mg/kg/day showed signs including soft stool, diarrhea, dirt lower abdomen, and dirt perirhinal part, a hunched posture, decreased spontaneous motility, or hypothermia. From vacuolar degeneration, regeneration or degeneration/necrosis of tubular epithelium in the kidney of males and females at 100 mg/kg/day in a histopathological examination (converted to a 90-day equivalent value: about 47 mg/kg/day) or higher (Reproductive test, METI (Access on Nov. 2011)), it was classified in Category 2 (kidney). Besides, focal inflammatory cellular infiltration in the lung observed in males only at 100 mg/kg/day or higher was reported to be an unknown mode of action in the same test. (Reproductive test, METI (Access on Nov. 2011)) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |  |
H400 |
P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.42 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 | |
H410 |
P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 2002)) and 72-hour NOEC = 0.072 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). If acute toxicity data are used for trophic levels for which chronic toxicity data are lacking, then it is classified in Category 2 from non-rapidly degradable (a degradation rate by BOD: 0 % (the existing chemicals survey program, 2002)) and 48-hour EC50 = 8.0 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). It was classified in Category 1 by a comparison between the above results. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/10/31 Addition of Rationale for the classification |