Substance Data
Safety information on chemicals is from the results of the existing chemicals survey program conducted by the Japanese Government (Ministry of Health, Labour and Welfare,
Ministry of Economy, Trade and Industry, and Ministry of the Environment).
User should check the details with the original report(in Jpanenese) for confirmation.
Data may not be evaluated or assessed by expert and confirmation of test results is needed if these data are used for assessment.
Some of Year in DATA SOURCE means tested year (financial year).
Endpoints
#70: Genetic toxicity in vitro
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Administrative data
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| Purpose flag
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| Data waiving
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| Justification for data waiving
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| Study result type
| : | experimental result |
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| Study period
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| Reliability
| : | 1 (reliable without restriction) |
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| Rationale for reliability incl. deficiencies
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DATA SOURCE
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Reference
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| Reference type | : | other: |
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| Reference type | : | Data sheet (published in 2004), prepared by Hazard-Data Assessment Committee of National Institute of Technology and Evaluation (NITE) based on the GLP study report obtained by NITE |
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| Owner company | : | National Institute of Technology and Evaluation |
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MATERIALS AND METHODS
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| Type of genotoxicity | : | gene mutation |
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| Type of study | : | bacterial reverse mutation assay (e.g. Ames test) |
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Test guideline
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| Qualifier | : | according to |
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| Guideline | : | OECD Guideline 471 (Bacterial Reverse Mutation Assay) |
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| GLP compliance | : | yes (incl. certificate) |
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Test materials
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Test material identity
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| Identifier | : | CAS RN |
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| Identity | : | 4435-53-4 |
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| Identifier | : | common name |
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| Identity | : | 3-Methoxybutyl acetate |
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| Details on test material | : | - Molecular weight: 146.19 /
- Molecular formula: C7H14O3 /
- Purity: 99.8 % |
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Method
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Species/strain
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| Species/strain | : | S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 |
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| Metabolic activation | : | with and without |
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| Metabolic activation system | : | S9mix(+) |
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| Species/strain | : | E. coli WP2 uvr A |
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| Metabolic activation | : | with and without |
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| Metabolic activation system | : | S9mix(+) |
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| Test concentrations | : | S9mix(-), (+): TA98, TA100, TA1535, TA1537, WP2uvrA; 0, 156, 313, 625, 1250, 2500, 5000 microg/plate |
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| Vehicle | : | Water |
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Controls
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| Positive controls | : | yes |
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| Positive controls | : | S9mix(-); ENNG (TA100, TA1535, WP2uvrA), 2-NF (TA98), 9-AA (TA1537) / S9mix(+); 2-AA (TA98, TA100, TA1535, TA1537, WP2uvrA) |
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| Remarks | : | ENNG: N-Ethyl-N'-nitro-N-nitrosoguanidine / 2-NF: 2-Nitrofluorene / 9-AA: 9-Aminoacridine / 2-AA: 2-Aminoanthracene |
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| Details on test system and conditions | : | - Procedure: Preincubation method /
- Number of plates: 3 plates per test /
- Number of replications: 2 |
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RESULTS AND DISCUSSION
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Test results
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| Species/strain | : | S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102 |
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| Metabolic activation | : | with and without |
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| Genotoxicity | : | negative |
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| Species/strain | : | E. coli WP2 uvr A |
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| Metabolic activation | : | with and without |
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| Genotoxicity | : | negative |
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| Any other information on results incl. tables | : |
Test results: Negative
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OVERALL REMARKS, ATTACHMENTS
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Attached background material
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Attached full study report
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APPLICANT'S SUMMARY AND CONCLUSION
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Interpretation of results
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Disclaimer
Aiming to keep the content of this site accurate and up to date, NITE makes no warranties or representations regarding the quality, accuracy,
completeness or reliability of information on the site.
NITE shall not be responsible for the accuracy, reliability or currency of any information on this site nor for any claims, damages or
losses resulting from their use.
NITE reserves the right, at our discretion, to change, modify, add to, or remove portions of information on this site at any time without notice.
The accuracy and linkage of association between CASRN and MITI number is not reviewed nor confirmed.
Please take note that Chemical Substance Names are translated by NITE and confirm from Original Chemical Names(in Japanese) for yourself.
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