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Chemical Management Center
The Chemical Management Center (CMC) set up CHRIP®, a database covering chemical substance information on laws, regulations, and hazard and risk assessment. CMC promotes businesses through the study of risk assessment methods of chemical substances. CMC supports risk assessment and management, as well as communication of those risks in Japan, by providing information and building intellectual foundations on chemical substances.
Furthermore, CMC provides technical support regarding enforcement of the Chemical Substance Control Law and the Law for PRTR and Promotion of Chemical Management and actively participates in international activities regarding chemical management within the OECD (Organization for Economic Co-operation and Development).
Through these activities, as a national center for human resources and information on "Comprehensive Chemical Management", CMC aims to contribute to the proper management of chemical substances, keeping international cooperation in mind. |
| July 1,2009 |
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"Guidance on a Consumer Product Risk Assessment for GHS Labelling" is now available. |
| February 10,2009 |
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"On the Handling of Test Results to be used as Judgment Data in Evaluation, etc. of New Chemical Substances" is now available. |
| February 10,2009 |
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"The Test Methods and
Judgment Criteria Concerning the Judgment etc. for assignment to the Monitoring Chemical Substances" is now available. |
| September 12,2008 |
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The English website
of Information about GHS has been opened. |
| July 25,2008 |
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"Execution Status of Law concerning the Examination and Regulation of Manufacture, etc. of Chemical Substances (CSCL) (2007)" is now available. |
| June 20,2008 |
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"2005 PRTR DATA REPORT, JAPAN"is now available. |
| June 20,2008 |
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"REPORTED PRTR DATA 2005: COMPARISON WITH PREVIOUS YEARS"is now available. |
| November 16,2007 |
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"Sumarry of the Interim Report; Nonylphenol" is now available. [ PDF 49KB] |
| November 16,2007 |
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"Sumarry of the Interim Report; Bis(2-ethylhexyl) Phthalate" is now available. [PDF 245KB] |
| November 16,2007 |
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"Sumarry of the Interim Report; Bisphenol A" is now available. [PDF 45KB] |
| September 14,2007 |
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"Execution Status of Law concerning the Examination and Regulation of Manufacture, etc. of Chemical Substances (CSCL) (2006)" is now available. |
| January 15,2007 |
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"REPORTED PRTR DATA 2004:COMPARISON WITH PREVIOUS YEARS" is now available. |
| January 15,2007 |
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2004 PRTR DATA REPORT, JAPAN" is now available. |
| April 28,2006 |
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"Risk Management Report-Current Status and Management Goals-Bis(2-ethylhexyl)Phthalate"is now available. [PDF 45KB] |
| October 11, 2005 |
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"COMPARISON OF REPORTED PRTR DATA 2001-2003 IN JAPAN" is now available. |
| August 24, 2005 |
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"2003 PRTR DATA REPORT, JAPAN" is now available. |
| April 28, 2005 |
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The English homepage of the Activities Related to the Chemical Substances Control Law has been opened. |
| April 12, 2005 |
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PRTR Estimation Manuals are revised and updated |
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 Main activities are for:
Developing the Chemical Risk Information Platform (CHRIP®)
To promote appropriate assessment and management of chemical risks, it is necessary to gather and organize reliable information fully and systematically, and to continue to disseminate this information to society.
As a national program for foundation of intellectual infrastructure, CMC gathers data on chemical risks, and has set up a database named the "Chemical Risk Information Platform (CHRIP®)" to publish data on the CMC website.
http://www.safe.nite.go.jp/english/db.html
Thus far, about 200,000 substances are listed, which are covered by laws and regulations at home and abroad. Intensive efforts have been made to integrate data on about 4,800 substances that, because of their high manufacturing or import volume into Japan, should be handled by priority from a perspective of risk management.
The following information is listed regarding each chemical substance; chemical name, CAS number, structural formula, laws and regulations in Japan and abroad, physical and chemical properties, hazard information, exposure information, and risk assessment. CHRIP® consists of the three databases shown on the left; "Total Search System for Chemical Substances", "PRTR substances database" and "Safety inspection data of existing chemical substances". They are designed to enable searching for any purpose.
Listed data are regularly checked and updated to ensure the reliability of the database, and newly regulated substances are promptly added to provide appropriate information.
Risk assessment methods and management, based on exposure assessments made using scientific methodology
CMC implements risk assessment of chemical substances, development of assessment methods, and management of chemical risk to realize sound economic and industrial activity in harmony with the environment, and to ensure that people use chemicals in safe and secure ways.
Activities Related to the Chemical Substances Control Law
The Law Concerning the Examination and Regulation of Manufacture, etc. of Chemical Substances
(The Chemical Substances Control Law)
This law, in order to prevent environmental pollution caused by chemical substances that may be hazardous to human health and/or impair the life and growth of flora and fauna, requires assessment of new chemical substances prior to their manufacture or import as well as regulates manufacturing, import and use, etc. of chemical substances, as necessary.
1. Assessment support of new chemical substances
CMC promotes efficient assessment of new chemical substances through its database on safety inspection and assessment results of new chemical substances, included according to the law. In addition, a common database in use amongst MHLW*1, METI *2and MOE*3 was set up in 2004 and has been in operation since 2006.
By utilizing the database, CMC studies information necessary for the assessment of new chemical substances, and compiles assessment materials on chemical safety. In addition, CMC acts as a contact for consultation, receives prior inquires from companies, and conducts hearings for notification. Also, CMC assigns the public names for new chemical substances.
*1 Ministry of Health, Labor and Welfare
*2 Ministry of Economy, Trade and Industry
*3 Ministry of Environment
2. Activities related to Good Laboratory Practices (GLP)
Kashin-ho stipulates that any safety inspection data used to assess new chemical substances should be inspected at test facilities conforming to Good Laboratory Practices (GLP). CMC conducts inspections of GLP facilities to assure reliability of test results and international compatibility.
3. Other activities related to observance and enforcement of Kashin-ho
To ensure international consistency, CMC assigns and announces CAS registry numbers and IUPAC names of existing chemical substances. CMC carries out surveys of actual manufacturing processes and import volumes of existing chemical substances as a basis for prioritizing their safety inspection, and also conducts on-site inspections to confirm if the law is properly implemented.
Furthermore, CMC compiled study reports on the relations between bioconcentration and n-octanol/water (log Pow), and between bioconcentration and molecular weight, and submitted them to the Chemical Substances Council to contribute to the review of assessment standards to ensure prompt and proper assessment procedures.
4. Activities related to the utilization of Structure-Activity Relationships ((Q)SAR)
To reasonably operate chemical management in Japan, CMC works to effectively utilize hazard assessment based on (Q)SAR
- Verification of (Q)SAR models using test data from Kashin-ho
Prediction accuracy, applicable range, and weak points can be clarified on every model by comparing (Q)SAR model predictions to the new and existing chemical test data on biodegradation and bioconcentration obtained through Kashin-ho. These results are used to improve upon previous models and to establish appropriate usage parameters.
- Development of a hydrolysis prediction system
To accurately predict hydrolyzability of chemical substances, which can be difficult using conventional methods, CMC developed a prediction system using reaction analyses based on quantum chemical calculation.
- Prioritizing safety inspections of existing chemical substances
The national government initiated safety inspections of chemical substances that were nationally distributed in 1973, when Kashin-ho was enacted (existing chemical substances).
Based on prediction results of the (Q)SAR model, and through comprehensive insights of experts', CMC assesses biodegradation and bioconcentration of existing chemical substances whose hazard information have not yet been obtained, and prioritizes actual measurement tests to be implemented.
Activities Related to the Law for PRTR and Promotion of Chemical Management
The Law Concerning Reporting, etc. of Releases to the Environment of Specific Chemical Substances and Promoting Improvements in Their Management
(The Law for PRTR and Promotion of Chemical Management)
Kakan-ho, enacted in 1999, operates using the PRTR and MSDS systems. It is intended to promote the improvement of voluntary management of chemical substances by companies, and to prevent problems for environmental conservation.
The PRTR is a system that companies use to notify others of the amount of chemical substances discharged into the environment, and transferred in waste by-products. 354 target substances are designated substances which may be harmful to human health and the ecosystem, and which are recognized to widely exist in the environment. Every year companies have to make notification to the national government via local governments, and then, the national government sums the data for publication.
The MSDS is a system to obligate companies to provide information on chemical properties and their proper handling, for use when chemical-based products are transferred and provided to other companies. 435 substances, including the PRTR substances, are designated as being potentially harmful to human health and the ecosystem.
As the sole agency handling the series of PRTR affairs from notification to publication, CMC conducts the following activities to ensure appropriate enforcement of Kakan-ho.
1. Activities related to summarizing discharges and other data
CMC established an electronic notification system to facilitate communication with companies on chemical discharges, and also established a notification management system that local governments and ministers governing the related companies can use to review the related laws, and accurately receive and confirm notification. Also, CMC set up a contact for inquiry on how to use the electronic notification system.
In addition, CMC makes efforts to improve the accuracy of notification data by checking their contents, and plays a central role in the PRTR system by recording and summarizing received notification data, and by making publication materials, etc..
2. Activities related to dissemination of Kakan-ho
CMC set up the PRTR support center to respond to technical and practical inquiries from companies and other related parties, to aid in the calculation of discharge amount limit required by the PRTR system, to disseminate notification requirements, and clear up basic issues of the MSDS system including compilation and provision of information.
In addition, to deeply understand published PRTR data, CMC provides discharge maps below and other Kakan-ho related information as an initial step for making comparison reports of past fiscal data.
Activities Related to the Chemical Weapons Prohibition Law
The Law on Prohibition of Chemical Weapons and Regulation etc. of Special Chemicals
(The Chemical Weapons Prohibition Law)
This law prohibits the production, use and possession of chemical weapons and regulates the production and use of Special Chemicals in order to ensure an appropriate enforcement of an international treaty i.e. the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction.
- Attending International Inspections and Inspecting Businesses
NITE attends international inspections of businesses enforced by the Organization for the Prohibition of Chemical Weapons (OPCW) based on the Chemical Weapons Convention, and also performs inspections of manufacturers permitted to produce or use Special Chemicals specified under the Chemical Weapons Prohibition Law in Japan.
Contact Us
Chemical Management Center
National Institute of Technology and Evaluation
2-49-10 Nishihara, Shibuya-ku, Tokyo, 151-0066 Japan
TEL:+81-3-3481-1977 FAX:+81-3-3481-2900
Mail:safe@nite.go.jp
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