NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	87-68-3
Chemical Name	Hexachlorobutadiene
Substance ID	m-nite-87-68-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	A flash point is 90 deg C (unknown test methods) (ICSC (2003) (J)). Because it is estimated to be >= 60 deg C and <= 93 deg C in prescribed test methods, it was classified in Category 4.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Classified in UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: 610degC (ICSC (J), 1997)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Rat LD50 value: 350mg/kg (EHC 155, 1994; ACGIH 7th. 2001; PATTY 4th., 1994), 250mg/kg (EHC 155, 1994; IARC 20, 1979), 200mg/kg and 46mg/kg (each EHC 155, 1994; PATTY 4th. 1994; ATSDR, 1994), 200mg/kg (EHC 155, 1994; PATTY 4th., 1994). Calculated based on the data above. Based on the calculated LD50 value of 128 mg/kg, it was classified as category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	Based on rabbit LD50 value: 1120mg/kg (EHC 156, 1994; ATSDR, 1994), it was set as Category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Classification not possible	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on mouse LC50 value (6 hours): 0.107mg/L (4 hour equivalent: 0.131mg/L (about 12.3ppm) (EHC 156, 1994)) which indicates steam with almost no mist from its vapor pressure. And it was classified as Category 1 by the ppm concentration standard.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	We judged that there was skin sensitization property based on the description that the positive rate was 100% in the test {EHC 156 (1994)} using the guinea pigs, we classified it to be Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Although it is negative in dominant lethal test using the rat which is multigeneration mutagenicity test using a germ cell (ATSDR, 1994), it is positive in oral administration and inhalation exposure by the chromosomal aberration test using the mouse marrow cell using a somatic cell, which is the in vivo mutagenicity test (EHC, 156, 1994), and there is no productive cell in vivo examination. So it is set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It is classified into a group 3 in IARC (73, 1999), C in EPA (IRIS, 1991 evaluations), and A3 in ACGIH (7th.2001). It is considered as Category 2 based on the classification of ACGIH which is latest assessment.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It was considered as Category 2 since in the perinatal period medication examination (feed-mix administration from pregnancy the 17th to after-delivery the 10th) of the rat, nephrotoxicity was acknowledged also in fetus by the dose nephrotoxicity etc. is observed in dam (NTP DB, 2006).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	The substance was classified as Category 1 (kidneys) based on the reports of kidney tubular degeneration in an inhalation exposure test in mice after 4 hours of exposure at a concentration within the guidance values of Category 1(EHC 156, 1994; ATSDR, 1994), and of kidney tubular necrosis in a percutaneous exposure test in rabbits at the non-lethal dose of 388mg/kg (EHC 156, 1994; ATSDR, 1994).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, bone marrow)	Danger	H372	P260 P264 P270 P314 P501	We classified it into Category 1 (liver, kidney, marrow) based on the description that in oral administration in the rat for 3-week to two-year, the denaturation, necrosis and tissue reproduction were observed in renal proximal tubule with the dosage of the guidance value range of Category 1 ((EHC 156, 1994, ACGIH 7th.2001) PATTY (4th. (1994), NTP DB (2006), and ATSDR (1994)), based on the description that the same disorder was observed also in the two-week to three-month oral study with the mouse (PATTY 4th.1994), and based on the description that in the study in feeding administration to rats and mouse with the dosage of guidance value range of Category 1, the swelling of the cell, the rise of aggregation of a basophil granule, a necrosis, and serum GPT activation in the liver were observed, and the description that in the feeding administration study for two weeks to a mouse, marrow hematopoietic cell decreases was observed with the dosage of guidance value range of Category 1 (EHC 156, 1994, ACGIH 7th.2001). PATTY (4th. (1994), NTP DB (2006), and ATSDR (1994).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=32microg/L of Crustacea (Mysid shrimp) (CaPSAR, 2001).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 24% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=9240 (existing chemical substances safety inspections data)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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