Item | Information |
---|---|
CAS RN | 7646-78-8 |
Chemical Name | Stannic chloride |
Substance ID | m-nite-7646-78-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2004)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2004)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2004)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It reacts violently with water and moisture and produce hydrogen chloride (ICSC (2004)), which is not a combustible gas, therefore, it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is an inorganic compound containing halogen, but the classification is not possible due to no data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, there is information that it attacks many metals (ICSC (2004)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Since this substance may react with water to generate a hydrochloric acid mist, please also refer to the classification result of hydrochloric acid (CAS RN: 7647-01-0). Classification not possible due to lack of data. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on the report of an LC50 value (4 hours) of 1.35 mg/L (=131 ppm) for rats for the vapor of this substance (vehicle: air with relative humidity >= 50%) (SIDS (2009)), it was classified in Category 2. Besides, since the LC50 value is lower than 90% of the saturated vapor concentration (23,692 ppm), the reference value in units of ppm was applied as a vapor without a mist. Moreover, in this report, there is a description (Test substance vapor formed a white cloud in contact with the humidified air) indicating that hydrogen chloride is generated by the reaction of this substance with moisture in the air as the vehicle. Based on this high-priority new information source (SIDS (2009)), the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There is a report that in a skin irritation test in which this substance was applied to rabbits for 1 or 4 hours (OECD TG 404), it showed corrosion (primary irritation score is unknown) (SIDS (2009)). In addition, there is a report that in a skin irritation test with rats, it is irritating to the skin at or above the concentration of 5% of this substance (SIDS (2009)). From the above results, it was classified in Category 1. Besides, this substance is classified as "C; R34" in EU DSD, and as "Skin Corr. 1B H314" in EU CLP. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
In an eye irritation test in which 0.1 mL of undiluted liquid of this substance was applied to rabbit eyes (washed or non-washed after 20 seconds), moderate to severe corneal opacity, moderate iris hyperemia and moderate conjunctival redness were observed in the washed group. Severe corneal opacity and extreme conjunctival whiteness were observed in the non-washed group (SIDS (2009)). In addition, eye closure was observed until 14 days later in the washed and the non-washed eye groups. From the above results, it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that in a sensitization test in which this substance was applied to rats, no sensitization was observed (SIDS (2009)). However, since it is not a test method according to the guidelines and the details of the results and others are unknown, the data were judged insufficient for use in classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test and positive in a chromosome aberration test, a micronucleus test and a sister chromatid exchange test with cultured mammalian cells (SIDS (2009), ATSDR (2005), CICAD 65 (2005)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Inorganic tin compounds are irritating to the mucosa (ATSDR (2005), HSDB (Access on July 2014)). There is a report of labored respiration, gasping, nasal and oral discharge, reduced response to noise and wet fur at 0.29-3.08 mg/L vapor by inhalation exposure to rats (SIDS (2009)). Since this substance was judged irritating to the respiratory tract from the above, it was classified in Category 3 (respiratory tract irritation). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In an epidemiological survey of 267 workers in a glass bottle manufacturing plant, respiratory symptoms such as wheezing, cough, chest pain and dyspnea occurred in workers exposed to fumes of this substance, the reason of which was considered to be the respiratory tract irritation by exposure to hydrogen chloride formed in the process of mixing this substance with water on heating (SIDS (2009), CICAD 65 (2005)). Therefore, since respiratory tract symptoms were expected to occur by inhalation of hydrogen chloride derivatively formed by hydrolysis of this substance in the workplaces handling this substance, it was classified in Category 1 (respiratory organs). In addition, there are reports that stannic oxide (IV), which is formed simultaneously by hydrolysis, causes pneumoconiosis (stannosis) in humans (SIDS (2009), ATSDR (2005)), and this also corresponds to Category 1 (respiratory organs). On the other hand, in experimental animals, although there are no findings on exposure to this substance, histopathological changes in the nasal cavity were observed in rats and mice that inhaled hydrogen chloride mist for 90 days (SIDS (2009)). Besides, as for stannous chloride (ID: 56; CAS RN: 7772-99-8), a related substance, it was considered that no respiratory tract effects occur in humans because it is unlikely to generate "hydrogen chloride or hydrochloric acid" or "stannous oxide (II)" by reaction with moisture in the air, unlike this substance. However, based on the findings on experimental animals through the oral route, the liver, kidney and hemal system were adopted as the target organs. On the other hand, there were no experimental animal data for this substance, so it was impossible to identify the target organs. Therefore, the classification results were different between the two substances (refer to the classification results of stannous chloride (ID: 56; CAS RN: 7772-99-8)). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
This substance readily decomposes in water and produces hydrochloric acid, pH drop by which is thought to cause effects to aquatic organisms. Because it is described that crustacea (Daphnia magna) is one of the most sensitive species from the results of tests using hydrochloric acid (SIDS, 2002), and the minimum concentration of hydrolyzed SnCl4 that would result in a similar pH/concentration of aqueous HCl, assuming complete hydrolysis, would be about 8.8 mg SnCl4/L in an unbuffered solution (SIDS, 2007), it was classified in Category 2. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified in Category 2 in acute toxicity, but it is estimated to be largely due to a drop of pH by hydrochloric acid produced, and it was judged to be inappropriate to use the classification result in acute toxicity for classification in chronic toxicity. Therefore, it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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