NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2675-77-6
Chemical Name	Chloroneb
Substance ID	m-nite-2675-77-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is combustible (GESTIS (Access on September 2017)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reported LD50 values for rats of > 5,000 mg/kg (88% in formulation, converted 100% equivalent value: > 4,400 mg/kg) (EPA Pesticide (2005)), and > 8,000 mg/kg (technical grade of active ingredient) (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a reported LD50 value of > 5,000 mg/kg (75% in formulation, converted 100% equivalent value: > 3,750 mg/kg) for rabbits (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), it was classified as "Not Classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a report that in a skin irritation test with rabbits (according to EPA OPPTS 870.2500), it was slightly irritating (EPA Pesticide (2005)), and a report that in another test with rabbits, mild irritation of the skin was observed (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), it was classified as "Not Classified" (Category 3 in UN GHS classification).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	There is a report that in an eye irritation test with rabbits (according to EPA OPPTS 870.2400), conjunctivitis was observed due to this substance (EPA Pesticide (2005)). On the other hand, there is a report that in another test with rabbits, no irritation of the cornea, iris, and conjunctiva was observed due to this substance, and it was negative (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). It was classified as "Classification not possible" due to the conflicting results.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	There is a description that in a skin sensitization test with guinea pigs (EPA OPPTS 870.2600 compliant), this substance is a sensitizer (EPA Pesticide (2005)). On the other hand, there are descriptions that in another test with guinea pigs, it was judged to be negative for skin sensitization on observation at 24 and 48 hours after the challenge (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)), and that in a repeated exposure test in the skin of guinea pigs, no sensitization was indicated (HSDB (Access on August 2017)). Therefore, it was classified as "Classification not possible" due to these contradicting results.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data. As for in vitro, positive and negative results were observed both in bacterial reverse mutation tests and in mammalian cell chromosome aberration tests (EPA Pesticide (2005), NTP DB (Access on August 2017), Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991), HSDB (Access on August 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, EPA judged in 2003 that "Data Are Inadequate for an Assessment of Human Carcinogenic Potential" of this substance (Chemicals Evaluated for Carcinogenic Potential: Annual Cancer Report (2016)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	There is no information on reproductive effects in humans. As for experimental animals, it is reported that in a 3-generation study with rats dosed by feeding, next generations were obtained after two-time mating in each generation of F0-F2, but at up to the high dose of 500 ppm, no abnormality was seen in mating performance, reproductive performance, and histopathological examination, and that NOEL was 500 ppm in this study (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). In developmental toxicity tests with pregnant rats or pregnant rabbits dosed by gavage, as for the test with rats, no developmental toxicity effect was observed at up to 1,000 mg/kg/day (HSDB (Access on August 2017), Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). On the other hand, in the test with rabbits, at 1,000 mg/kg/day, marginally lower body weight and anorexia in maternal animals, and lower body weight and increases in skeletal and ventral midline anomalies in fetuses were observed (HSDB (Access on August 2017)). Details on the anomalies (severity, frequency of incidence, etc.) are unknown, and it could not be judged whether they could be adequate evidence to support assigning a category. From the above, although no adverse effects on reproduction were observed in the 3-generation study with rats, there is a possibility that the doses were not high enough to cause clear general toxicity effects in maternal animals. In addition, as for developmental toxicity effects, it is not possible to judge the degree of the developmental effects from the available information. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	There is no information on single exposure in humans. As for experimental animals, there is a report that in a single oral administration test with mice, at 1,000 mg/kg within the range of Category 2, a significant decrease in body temperature was observed, but this resolved after 3 hours, and at 3,000 mg/kg exceeding the Category 2, a significant decrease in body temperature, hyporeactivity, mild hyperesthesia, tremor, excitement state, spasm, reduced grip strength, and tendency to reduce pupil diameter were observed, however, after 5 hours, most of the symptoms except spasm and tremor resolved (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). Transient effects on the central nervous system were observed, but the doses exceeded the range of Category 2, therefore, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	As for experimental animals, there is a report that in a 24-month toxicity study with dogs dosed by feeding, at the highest dose (2,500-10,000 ppm: max. 10,000 ppm, 7,500 ppm after the 75th week) (converted guidance value: 62.5-250 mg/kg/day), a decrease in body weight, increases in GPT (ALT) and alkaline phosphatase activity, increases in absolute and relative weights of the liver, increases in absolute and relative weights of the adrenal glands, hyperactivity of the thyroid, pigmentation of the liver, and catarrhal gastritis were observed (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). It was judged that this dose approximately exceeded the guidance value range for Category 2. In addition, in a 24-month toxicity study with rats dosed by feeding, at the highest dose of 2,500 ppm (converted guidance value: 125 mg/kg/day) exceeding the guidance value range for Category 2, only reduced body weight gain and decreased food consumption were observed (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" Vol.8 (Japan Crop Protection Association, 1991)). From the above, it corresponds to "Not Classified," however, since there are no data by other routes, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 96-hour LC50 = 3.7 mg/L for fish (Oncorhynchus mykiss) (NLM HSDB: 2010, EPA AQUIRE: 2017, EPA Pesticide Ecotoxicity Database), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and acute toxicity Category 2, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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