NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	11103-86-9
Chemical Name	Potassium dizinc(II) bis(chromate) hydroxide
Substance ID	m-nite-11103-86-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC(J) (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC(J) (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC(J) (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Cr), but it is estimated that it does not react vigorously with water because the measured water solubility data of 0.5 - 1.5 g/L was obtained (ICSC(J) (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is estimated that it is strongly oxidizing due to hexavalent chromium oxide, but the classification is not possible due to no test data on this substance.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Category 1B	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Chromium and its compounds are classified in Group 2 of occupational airway sensitizers in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016). This corresponds to Category 1A according to the GHS classification guidance for the Japanese Government. However, this substance was newly classified in Group 2 of occupational airway sensitizers as a substance which sensitization has not clarified yet through epidemiologic research, based on the classification standard for sensitization (provisional, May 26, 2010). Therefore, it was judged as inappropriate to classify this substance in Category 1A and it was classified in Category 1B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1A	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Chromium and its compounds are designated as Group 1 of occupational skin sensitizers in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016). Also, it is known that dermatitis develops in workers handling products containing zinc chromate, and skin sensitization by zinc chromate is suggested (DFGOT Vol. 15 (1997)). From the above, this substance was classified in Category 1A.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a micronucleus test using mouse peripheral blood is positive. 　As for in vitro, a bacterial reverse mutation test is positive (NTP DB (Access on August 2016)). 　From the above, this substance was classified in Category 2 according to the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	This substance corresponds to hexavalent chromium compounds and IARC classifies it in Group 1 (IARC 100c (2012)), ACGIH classifies it in A1 (ACGIH (7th, 2001)). Therefore, this substance was classified in Category 1A for this hazard class. 　Besides, EU classifies this substance in Carc. 1B, and designated it as SVHC (ECHA Support Document (2011)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is no data available for this substance itself, but information on hexavalent chromium compounds is considered to be available for classification. Regarding reproductive effects of chromium (VI) in humans, there are reports on workers in metal plating factories in China, but there is no accurate description of the exposed period or exposure concentration, therefore, it is thought to be insufficient to be used as the evidence for reproductive toxicity (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014)). 　As for experimental animals, in an 18-month inhalation exposure test with the aerosol of sodium dichromate (Cr (VI) and chromium oxide (Cr (III)) mixed at a ratio of 3:2, effects on the testes were not observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014), CICAD 78 (2013)). 　As for oral route, in the study in which female rats were administered female rats were administered potassium dichromate in drinking water for 20-days before mating, and then mated with untreated males, the mating rate and conception rate decreased at doses of 38 mg/kg Cr (VI)/kg/day or more, and decrease in the number of corpus luteum, a reduction in implantation number and increase in preimplantation embryo loss number were observed at 70 mg Cr (VI)/kg/day or more (CICAD 78 (2013)). 　In addition, in a study in which potassium dichromate was administered to male and female mice for 12 weeks, mating with non-treated male and female mice, in both the dosed male group and dosed female group, decrease in the implantation number and the number of surviving fetuses were observed at 6 mg/kg Cr(VI)/kg/day or more, and as for the dosed male group, a decrease in the seminal vesicles and the preputial gland weight was observed, and as for the dosed female group, an increase in ovary relative weight was observed (CICAD 78 (2013)). On the other hand, in tests in which potassium dichromate was administered in the diet to rats or mice, no effect was observed in reproductive organs (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014), CICAD 78 (2013)). Thus, as for the effects on reproductive of hexavalent chromium compounds in experimental animals, there are both negative and positive results reported. 　Japan Society For Occupational Health (JSOH) had determined that the epidemiological investigations in humans are inadequate as evidence of classification, and in animals studies with hexavalent chromium compounds, reproductive and developmental toxicity was observed when administered by drinking water, but not observed when administered by feeding, and it could not be said that there is clear evidence of reproductive toxicity in animals studies. Therefore, Japan Society For Occupational Health (JSOH) classified chromium and chromium compounds in Group 3 of reproductive toxicity (OEL Documentations (Japan Society For Occupational Health (JSOH), 2014), Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016)). 　From the above, based on the information on hexavalent chromium compounds, mainly, it was judged appropriate to classify this substance in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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