NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	108-18-9
Chemical Name	Diisopropylamine
Substance ID	m-nite-108-18-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of -7 deg C (closed cup), and a boiling point of 82 deg C (GESTIS (Access on September 2017)), it was classified in Category 2. Besides, it is classified in Cass 3, Subsidiary risk 8, PGII in UNRTDG (UN 1158).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 285 deg C (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a report of an LD50 value of 770 mg/kg for rats (ACGIH (7th, 2001), PATTY (6th, 2012)), this substance was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There is a reported LD50 value of > 10,000 mg/kg for rabbits (ChemID (Access on January 2018)), and it corresponds to "Not classified." There is a reported LD50 value of > 2,000 mg/kg for rats or rabbits (it was unknown which of animal species was used, but described as a test equivalent to OECD TG 402) (SIAP (2013)), and it corresponds to "Not classified." From the above, this substance was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on a reported LC50 value of 4.8 mg/L (1,162 ppm) (converted 4-hour equivalent value: 3.4 mg/L (821 ppm)) (HSDB (Access on August 2017)) in a 2-hour inhalation exposure test with rats, this substance was classified in Category 3. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (104,792 ppm), a reference value in the unit of ppm was applied as vapour with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1A	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a skin irritation test with rabbits (OECD TG 404 compliant), clear evidence of necrosis (discoloration to reddish brown and greenish brown at the application site) was observed within 24 hours after the 3-minute application of this substance. This was followed by drying and roughening, resulting in desquamation and open wounds, and becoming scarred. There is a description that the skin tissue showed irreversible damage in all its layers (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause strong skin irritation and corrosivity (SIAP (2013)) and a description that the pH of this substance was 12.5 (HSDB (Access on August 2017)). Therefore, it was classified in Category 1A. Besides, in EU CLP classification, this substance is classified as "Skin Corr. 1B, H314" (ECHA CL Inventory (Access on August 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	This substance was classified in Category 1A for skin corrosion/irritation. In eye irritation tests with rabbits (OECD TG 405 compliant), the ocular disorders did not resolve within the observation period of 8 days, and although, without data on Day 21, the irreversibility of the disorder is unclear, this substance caused disorders of the cornea, iris and conjunctiva, and was reported as corrosive (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause eye irritation and furthermore, may have corrosivity (SIAP (2013)). Therefore, this substance was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is a description that in a skin sensitization test with guinea pigs (OECD TG 406 compliant), skin sensitization was not observed for this substance (ECHA registration information (Access on December 2017)), but since no information on other animal tests and humans was available, this substance was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is no in vivo data. As for in vitro, a bacterial reverse mutation test was negative (NTP DB (Access on September 2017), HSDB (Access on August 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. In addition, there was a report that as a result of inhalation exposure in rats for 1 month, atrophy and decreased secretion in seminal vesicles and increased relative testes weights were observed at a concentration of 2.0 mg/L at which various effects such as corrosivity were present (SIAP (2013)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In humans there is a description that this substance is a severe pulmonary irritant (PATTY (6th, 2012)). In addition, there is a report that workers who were exposed by inhalation at 25-50 ppm of this substance complained of disturbances of vision, nausea and headaches (ACGIH (7th, 2001), PATTY (6th, 2012)). As for experimental animals, it is reported that in tests with several animal species (although no details are described, there is a possibility the species were rabbits, guinea pigs, rats and cats from the description in other citations of the same reference), lacrimation, corneal clouding and severe irritation of the respiratory tract were observed in inhalation exposure at 2,207 ppm for 3 hours, and at autopsy, pulmonary edema and hemorrhage were observed (PATTY (6th, 2012)). The converted 4-hour equivalent value of the dose at which the effect was observed in animals is 1,911ppm (7.9 mg/L), which corresponds to Category 1. Based on the above information on humans and animals, the target organ of this substance was considered to be the respiratory organs. Therefore, it was classified in Category 1 (respiratory organs). As for disturbances of vision in humans, since this substance was classified in Category 1 for serious eye damage/eye irritation class, it is not adopted as evidence. Since information of nausea and headache in humans was insufficient as evidence for the classification, it was not adopted. Although it was classified in Category 2 (respiratory system) in the previous classification, since PATTY and ACGIH are the information sources listed in List 1, the category was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance is a strong alkaline liquid (PATTY (6th, 2012)), in humans there is a report that at an average concentration of 25-50 ppm, it caused visual disturbance (haziness or halos around lights), nausea and headaches to workers (ACGIH (7th, 2001), PATTY (6th, 2012)). In addition, there is a report that in tests in which rats, rabbits, guinea pigs and cats were exposed by inhalation at 600 ppm for 8 weeks (7 hours/day, 40 times), there were corneal opacity due to irritation accompanied with partial or total loss of vision, and death of rabbits and guinea pigs (ACGIH (7th, 2001)). Since these effects on the eyes were classified in Category 1 for serious eye damage/eye irritation, they were not adopted.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the kinematic viscosity was calculated as 0.56 mm2/sec (25/20 deg C) by numerical data (viscosity: 0.40 mPa*s (25 deg C), density (specific gravity): 0.7169 (20/4 deg C)) listed in HSDB (Access on August 2017).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 72-hour EC50 = 0.21 mg/L for algae (Oscillatoria agardhii) (EPA AQUIRE: 2017, Hanstveit, A. O. et al. (1985)), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (BIOWIN), 35-day NOEC (survival rate) = 187 mg/L for fish (Gasterosteus aculeatus) (EPA AQUIRE: 2017, Van den Dikkenberg, R. P. et al. (1989)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 72-hour EC50 = 0.21 mg/L for algae (Oscillatoria agardhii) (EPA AQUIRE: 2017, Hanstveit, A. O. et al. (1985)). By drawing a comparison between the above results, it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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