NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	105-45-3
Chemical Name	methyl acetoacetate
Substance ID	m-nite-105-45-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point is 67degC (closed cup) (Hommel, 1996), the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition point is 280degC (Chapman ver. 16:2, 2008; Hommel, 1996; HSDB, 2005), which is above 70degC, the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Not classified	- -	-	-	Based on the description that as durable transport container material, aluminum, high-grade steel, synthetic substances, glasses, or porcelain enamel is used (Hommel, 1996), the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	In rat tests (OECD TG 401, GLP), no mortality occurred in 2000 mg/kg groups (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008). In other rat tests, LD50 was found to be 2580-3370 mg/kg bw (IUCLID, 2000; HSDB, 2005). Based on these results, the substance was classified into the "Not classified" category using the JIS criteria. In the United Nations classification, it falls under Category 5.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since its rabbit LD50 is > 5000 mg/kg bw (IUCLID, 2000), the substance was classified into the "Not classified" category. The information in PATTY 5th (2001) was not used as grounds for classification because original literature cited there is outdated.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Its saturated vapour pressure concentration is calculated as 1168 ppm by converting its vapour pressure value of 118 Pa at 25degC (Howard, 1997; HSDB, 2005). Its rat LC50 of > 6.6 mg/L (conversion value: > 1390 ppm), obtained in 4-hour inhalation tests using rats, is greater than its saturated vapour pressure concentration. Thus, the substance was classified as mist into the "Not classified" category using the JIS criteria.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Rabbit tests (OECD TG 404, GLP) (IUCLID, 2000) found that the substance is not irritating. Based on this description, it was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In both of two studies using rabbits (OECD TG 405, GLP and non-GLP studies) (IUCLID, 2000), the substance was found to be irritating. Based on these results and since it is rated as R36 in the EU classification, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	A human maximization test (IUCLID, 2000) found that the substance is not sensitizing. Since this is the only tests result available, and there is not sufficient information to carry out classification. Thus, the substance was categorized into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Several negative results and one positive result have been documented in in-vitro mutagenicity tests (a reverse mutation test using bacteria, a chromosomal aberration test using cultured cells from Chinese hamsters, and a cytogenetic assay using CHO cells) (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008; IUCLID, 2000). Since these results are insufficient to carry out classification, the substance was categorized into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	Two-year oral administration tests using rats or mice (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare), 2005) found that no increase in cases of tumorigenesis or tumor-related incidences was detected in either sex. Based on this description, the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In OECD's combined repeated oral administration / reproduction and developmental studies using rats (GLP) (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008), no general toxic effects on parental animals, no effects on reproductive functions, or no abnormalities in observations of delivery, nursing, or neonates were noted at the highest test dose of 1000 mg/kg. However, since there are no test results on teratogenicity, the substance was classified into the "Classification not possible" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In single oral administration tests using rats (HSDB, 2005), administration of 1.0 and 2.0 g/kg was associated with sluggish movements, and animals returned to normal behavior within 48 hours. In addition, animals dosed at 2.5 to 4.0 g/kg exhibited lethargy, and at 8.0 g/kg animals immediately became comatose. Based on these reports, the substance was classified into Category 3 (narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In OECD's combined repeated oral administration / reproduction and developmental studies using rats (Crj: CD: Sprague-Dawley strain) (GLP) (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008), no mortality occurred, no changes in clinical observations were noted, and no differences in body weight and food consumption were detected relative to control in groups treated at 1000 mg/kg, the highest dose tested. In 100 mg/kg groups, one male rat developed spleen hypertrophy and was diagnosed with leukemia. However, there is a report that leukemia is a spontaneously generated pathological change seen in rats of the same strain and same age by week (C.B. Richter, Laboratory Investigation, 26,419 (1972)), indicating that the change was unrelated to the test substance administered. Also, in 1000 mg/kg groups, one rat showed infiltration of lymphocytes under the left ventricular endocardium, but it occurred at a very low frequency, and there is a report that this pathological change is also attributed to spontaneous generation in rats (I. Narama. 1992. Toxicological study Lecture 5. In: A. Maekawa and Y. Hayashi (eds.), Toxicological pathology. Chijinshokan, Tokyo. p.59.), indicating that the change was unrelated to the test substance administered. Thus, regarding oral administration, the substance falls under the "Not classified" category. However, since data on other administration routes are not available, the substance was classified into the "Classification not possible" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Its 48-hour EC50 is > 236.9 mg/L for crustaceans (Daphnia magna), 72-hour ErC50 is > 978 mg/L for algae (Pseudokirchneriella subcapitata), and 96-hour LC50 is > 111.4 mg/L for fish (fathead minnow) (HSDB, 2005). Based on these values, the substance was classified into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it is water soluble (water solubility = 500 g/L (PHYSPROP Database, 2008)), and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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