Item | Information |
---|---|
CAS RN | 924-42-5 |
Chemical Name | N-Methylolacrylamide |
Substance ID | R03-C-067-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2010 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1), although it was with one animal species (mice) in a proper test, since an increase in the incidence of tumors including malignant ones in both males and females (alveolar-bronchiolar adenomas and carcinomas (combined) in males and females) was observed and it was judged that there was sufficient evidence for carcinogenicity in animal tests, it was classified in Category 1B. Based on a new evaluation, the classification result was changed. [Evidence Data] (1) It was reported that, in a two-year oral administration test using mice, with doses of 25 mg/kg/day and 50 mg/kg/day, the incidences of tumors of the Harderian gland (adenomas in males and females), the liver (hepatocellular adenomas and carcinomas (combined) in males, hepatocellular adenomas in females), the lung (alveolar/bronchiolar adenomas and carcinomas (combined) in males and females), and the ovary (benign granulosa cell tumors in females) increased (NTP TR352 (1989), IARC 60 (1994), CLH report (2017)). (2) From (1), the NTP and the EU concluded that there was clear evidence in mice for the carcinogenicity and the IARC concluded that there was limited evidence in mice for the carcinogenicity (NTP TR352 (1989), IARC 60 (1994), CLH report (2017)). (3) As for the classification results by domestic and international evaluation organizations, the IARC classified it in Group 3 (IARC 60 (1994)) since there was limited evidence in experimental animals and there were no findings in human based on (1), and the EU classified it in Carc. 1B (EU-CLP Classification Results (Accessed Jan. 2022)) based on (1), and additionally, since acrylamide (CAS RN 79-06-1), which is a structural analog, has been classified in Carc. 1B. [Reference Data, etc.] (4) It was reported that, in a two-year oral administration test using rats, with doses of up to 12 mg/kg/day, no carcinogenic effects were observed (NTP TR352 (1989), IARC 60 (1994), CLH report (2017)). |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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