Item | Information |
---|---|
CAS RN | 7718-54-9 |
Chemical Name | Nickel chloride |
Substance ID | R03-C-060-MHLW, MOE |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2009 FY2008 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 3. Besides, based on the converted value equivalent to nickel chloride, the classification result was changed. [Evidence Data] (1) LD50 (Nickel Chloride Hexahydrate (CAS RN: 7718-54-9)) for rats (females): 210 mg/kg (converted value equivalent to nickel chloride: 115 mg/kg) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2017), Hazard Assessment Report (CERI, NITE, 2008)) (2) LD50 (Nickel Chloride Hexahydrate) for rats (males): 175 mg/kg (converted value equivalent to nickel chloride: 95.4 mg/kg) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2017), Hazard Assessment Report (CERI, NITE, 2008)) (3) LD50 (Nickel Chloride Hexahydrate) for rats (females): 500 mg/kg (converted value equivalent to nickel chloride: 273 mg/kg) (OECD TG 425) (AICIS IMAP (2014), EU EFSA (2018)) [Reference Data, etc.] (4) This substance was classified in Category 3 in the EU CLH. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) LC50 (Nickel Chloride Hexahydrate (CAS RN: 7718-54-9), 4 hours) for rats (males): 0.593 mg/L (converted value equivalent to nickel chloride: 0.323 mg/L) (OECD TG 403, GLP) (REACH registration dossier (Accessed Jan. 2022)) (2) LC50 (Nickel Chloride Hexahydrate, 4 hours) for rats (females): 0.746 mg/L (converted value equivalent to nickel chloride: 0.407 mg/L) (OECD TG 403, GLP) (REACH registration dossier (Accessed Jan. 2022)) |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 48-hour LC50 = 0.013 mg Ni/L (a converted value equivalent to this substance: 0.029 mg/L) for crustacea (Ceriodaphnia dubia) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Sufficient data on rapid degradability were not obtained. It was classified in Category 1 from 17-day NOEC = 0.002 mg/L for crustacea (Ceriodaphnia dubia) (EU RAR, 2008). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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