Item | Information |
---|---|
CAS RN | 67-66-3 |
Chemical Name | Chloroform |
Substance ID | R03-C-059-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2015 FY2014 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] Based on (1) to (4), it was classified in Category 4. [Evidence Data] (1) LD50 for rats (males): 908 mg/kg (OECD TG 401) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2009), DFG MAK (2000)) (2) LD50 for rats (females): 1,117 mg/kg (OECD TG 401) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2009), DFG MAK (2000)) (3) LD50 for rats (males): 445 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), ATSDR, (1997), CLH Report (2010)) (4) LD50 for rats (males): 2,000 mg/kg (ATSDR (1997), DFG MAK (2000), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), the data on rabbits was adopted and it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: > 3,980 mg/kg (AICIS IMAP (2014)) [Reference Data, etc.] (2) LD50 for mice: between 696 to 3,245 mg/kg (Hazard Assessment Report (CERI, NITE, 2006)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 3 by adopting the category with the higher hazard. Also, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (233,290 ppm), it was judged to be a vapor and classified based on the reference value in units of ppmV. Based on the new findings, the classification result was changed. [Evidence Data] (1) LC50 (6 hours) for rats: 9.2 g/m3 (converted 4-hour equivalent value: 11.3 g/m3, 2,310 ppm) (Risk Assessment Documents (National Institute of Advanced Industrial Science and Technology, 2007), EURAR (2007), AICIS IMAP (2014)) (2) LC50 (4 hours) for rats: 9,770 ppm (ATSDR (1997), US AEGL (2012)) (3) LC50 (4 hours) for rats: 47,702 mg/m3 (9,775 ppm) (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 1999)) [Reference Data, etc.] (4) This substance was classified in Category 3 in the EU CLH. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|