Item | Information |
---|---|
CAS RN | 62-73-7 |
Chemical Name | Dimethyl 2,2-dichlorovinyl phosphate (synonym: DDVP) |
Substance ID | R03-C-052-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2011 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
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1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), an increase in the incidence of tumors including malign ones was observed in two animal species (malignant fibrous histiocytoma in male rat, forestomach tumor in female mice), and in animal studies, it was considered that there was sufficient evidence of carcinogenicity, and therefore, this substance was classified in Category 1B. [Evidence Data] (1) In a carcinogenicity study with rats and mice dosed by feeding for 80 weeks (after the dosing period, rats were observed for 30 weeks and mice were observed for 12 to 14 weeks before sacrifice), a dose-dependent increase in the incidence of malignant fibrous histiocytoma was observed in male rats (0, 150, 1,000/300 ppm). But there was no significant increase in tumors in female rats and male and female mice (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2013), IARC 53 (1991), ACGIH (2014)). (2) In a carcinogenicity study with rats and mice dosed by gavage for 2 years (5 days/week), in the test with rats (males and females: 0, 4, 8 mg/kg/day), dose-dependent increases in the incidences of pancreatic acinar cell adenomas and mononuclear cell leukemia in males and mammary gland tumors with mammary gland fibromas and fibroadenomas combined in females were observed. The NTP concluded that some evidence of carcinogenicity for male rats and equivocal evidence for female rats were obtained. In contrast, in the test with mice (males: 0, 10, 20 mg/kg/day, females: 0, 20, 40 mg/kg/day), a dose-dependent increase in forestomach papillomas was observed in both males and females. At 40 mg/kg/day, a significant increase in the incidence of forestomach papillomas was observed in females compared to controls, and squamous cell carcinomas were also observed in 2/50 animals. The NTP concluded that some evidence of carcinogenicity for male mice and clear evidence for female mice were obtained (NTP TR342 (1989), Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2013), IARC 53 (1991), ACGIH (2014)). (3) This substance is a target substance in the public announcement on guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act (guidelines in order to prevent the impairment of worker's health, announcement No. 27 on February 7, 2020). (4) As for the classification results by domestic and international organizations, the IARC classified this substance in Group 2B (IARC 53 (1991)), the Japan Society For Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2021): proposed in 2001), the EPA classified it in S (EPA OPP Annual Cancer Report (2020): 2000), and the ACGIH classified it in A4 (ACGIH (2014): proposed in 2000). [Reference Data] (5) The ACGIH assessed the test results including (1) and (2) and concluded that the tumors observed in rats and mice were inconsistent and the relevance of forestomach tumors, etc. to humans was unclear. Therefore, it was classified in A4 (ACGIH (2014)). |
7 | Reproductive toxicity | - |
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- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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