NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	693-98-1
Chemical Name	2-Methylimidazole
Substance ID	R03-C-040-MHLW
Classification year (FY)	FY2021
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2010
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-
17	Desensitized explosives	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) to (3), it was classified in Category 1B. It was classified based on the new information source. [Evidence Data] (1) In a reproduction/developmental toxicity screening test (OECD TG 421, GLP) with rats dosed by gavage, at the highest dose of 500 mg/kg/day, 2/10 dams died during or shortly after parturition, which was considered to be an adverse effect of the administration of this substance on parturition (complicated parturition). In addition, reduced body weight gain, a tendency to an increase in the duration of pregnancy (within the background data), an increase in the number of stillborn pups, and a decrease in the live birth index were observed in dams of the same group. It was reported that, in offspring, a dose-dependent increase in the incidence with aneurysm (aorta, the region of the ductus arteriosus and the pulmonary trunk) was observed from the low dose (50 mg/kg/day), and a decrease in the viability index on postnatal days 0 to 4 was observed in the highest dose group (CLH Report (2016), AICIS IMAP (2016), ECHA RAC Opinion (2017), REACH registration dossier (Accessed Oct. 2021)). (2) It was reported that, in a developmental toxicity study (GLP) with female rats dosed by gavage from day 6 of gestation to postnatal day 3, no effects were observed in dams up to the highest dose of 50 mg/kg/day, but in offspring, an increase in the incidence with dissecting aneurysm of the aorta and intramural hemorrhage was observed from the low dose (2 mg/kg/day) (CLH Report (2016), AICIS IMAP (2016), ECHA RAC Opinion (2017), REACH registration dossier (Accessed Oct. 2021)). (3) Based on (1) and (2), a dose-dependent increase in the incidence of aneurysm was observed from the low dose of 2 mg/kg/day in two tests. A decrease in the viability index was observed in offspring at 500 mg/kg/day. Since the maternal toxicity is limited to body weight changes at 500mg/kg/day, the developmental effects in offspring cannot be considered to be secondary to maternal toxicity. Therefore, it was reported that the classification in Repr. 1B was determined to be appropriate (CLH Report (2016), ECHA RAC Opinion (2017)). [Reference Data, etc.] (4) In the EU CLP, it was classified in Repr. 1B (EU CLP Classification Results (Accessed Oct. 2021)).
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information