Item | Information |
---|---|
CAS RN | 98-56-6 |
Chemical Name | p-Chloro-alpha,alpha,alpha-trifluorotoluene |
Substance ID | R03-C-012-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2018 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), since there was sufficient evidence of carcinogenicity in two or more animal species, it was classified in Category 1B. [Evidence Data] (1) It was reported that, in a two-year carcinogenicity study with rats by inhalation exposure (100 to 1,000 ppm), a significant increase and positive trend in the incidence of thyroid C-cell adenoma was observed in males and females, a significant positive trend in the incidence of bronchioloalveolar carcinoma was observed in males, and a significant increase and positive trend in the incidence of benign pheochromocytoma in the adrenal medulla, a significant positive trend in the incidence of C-cell adenoma or carcinoma (combined), and a positive trend in the incidences of adenocarcinoma and stromal polyp in the uterus were observed in females (IARC 125 (2020), NTP TR594 (2018)). (2) It was reported that, in a two-year carcinogenicity study with mice by inhalation exposure (100 to 400 ppm), a significant increase and positive trend in the incidences of hepatocellular carcinoma and hepatoblastoma and a significant increase and positive trend in the incidence of hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma (combined) were observed in males and females, and a significant increase and positive trend in the incidence of hepatocellular adenoma and a significant increase and positive trend in the incidence of Harderian gland adenoma were observed in females (IARC 125 (2020), NTP TR594 (2018)). (3) As for the classification results by international organizations, IARC classified it in Group 2B based on sufficient evidence for carcinogenicity in experimental animals in (2) and (3) (IARC 125 (2020)). [Reference Data, etc.] (4) An epidemiologic assessment of a small cohort of workers at a plant in the United States reported a high incidence of respiratory system and stomach cancers. However, the workers were exposed to a large mixture of chemicals in addition to this substance (NTP TR594 (2018)). |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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