Item | Information |
---|---|
CAS RN | 7727-18-6 |
Chemical Name | Vanadium trichloride oxide |
Substance ID | R01-B-095 |
Classification year (FY) | FY2019 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2010 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
2 | Flammable gases | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
3 | Aerosols | * |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." |
4 | Oxidizing gases | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
5 | Gases under pressure | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
6 | Flammable liquids | * |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on October 2019)). |
7 | Flammable solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
8 | Self-reactive substances and mixtures | * |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)." |
9 | Pyrophoric liquids | * |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on October 2019)). |
10 | Pyrophoric solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
11 | Self-heating substances and mixtures | * |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on October 2019)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | * |
- |
- | - | It contains a metal (V), and there is information that it reacts vigorously with water (GESTIS (Access on October 2019)), or humidity hydrolyzes it into vanadic acid and hydrochloric acid (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). Because products do not contain flammable gases, it was classified as "Not classified." |
13 | Oxidizing liquids | * |
- |
- | - | It is an inorganic compound containing halogen (Cl) (but not oxygen). However, the classification is not possible due to no data. |
14 | Oxidizing solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
15 | Organic peroxides | * |
- |
- | - | Inorganic compound. It was classified as "Not classified (Not applicable)." |
16 | Corrosive to metals | * |
- |
- | - | No data available. |
17 | Desensitized explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 3. The category was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) LD50 for rats: 140 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), HSDB (Access on October 2019)) |
1 | Acute toxicity (Dermal) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | * |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
1 | Acute toxicity (Inhalation: Vapours) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) It is described that this substance is hydrolyzed by moisture to vanadic acid and hydrochloric acid (CAS RN 7647-01-0) (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). Hydrochloric acid is corrosive and irritating to the respiratory tract (SIDS (2005)). (2) This substance is considered to be corrosive from its physico-chemical property (HCl generation) and the weight of evidence (industrial practice) (REACH registration dossier (Access on December 2019)). (3) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) It was stated that this substance was hydrolyzed by moisture to vanadic acid and hydrochloric acid (CAS RN 7647-01-0) (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). Hydrochloric acid is corrosive and irritating to the respiratory tract (SIDS (2005)). (2) This substance is considered to be corrosive from its physico-chemical property (HCl generation) and the weight of evidence (industrial practice) (REACH registration dossier (Access on December 2019)). (3) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders. [Reference Data, etc.] (4) Vanadium compounds act as an irritant to the conjunctiva and respiratory tract (HSDB (Access on October 2019)). |
4 | Respiratory sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | * |
- |
- | - |
[Rationale for the Classification] Although there is a description of (1), classification was not possible due to lack of data. [Reference Data, etc.] (1) Seven out of 66 patients with a hip prosthesis reacted to 2% or 5% of this substance in petrolatum in an epicutaneous test. An irritative reaction to 5% of this substance in petrolatum was observed in 17 other patients (DFGOT vol.29 (2009)). |
5 | Germ cell mutagenicity | * |
- |
- | - |
[Rationale for the Classification] There is no in vivo data available. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, a negative result was reported in a bacterial reverse mutation test (DFGOT vol.29 (2009)). |
6 | Carcinogenicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
7 | Reproductive toxicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (respiratory organs). Since new data were obtained, the classification was changed from the previous classification. [Evidence Data] (1) It was described that this substance was hydrolyzed by moisture to vanadic acid and hydrochloric acid (CAS RN 7647-01-0) (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). There is a description that hydrochloric acid is corrosive and irritating to the respiratory tract and affects the respiratory organs (SIDS (2005)). (2) It was described that vanadium compounds act chiefly as an irritant to the conjunctiva and respiratory tract (HSDB (Access on October 2019)). (3) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 1 (respiratory organs). Since new data were obtained, the classification was changed from the previous classification. [Evidence Data] (1) In "Disease designated by the Minister of Health, Labour and Welfare due to work involving exposure to simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare" (Ministry of Labor Notification No. 33, 1996), the diseases designated by the Minister of Labour (currently the Minister of Health, Labour and Welfare) for vanadium and its compounds are described as skin disorders, anterior eye disorders or respiratory tract/pulmonary disorders. |
10 | Aspiration hazard | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
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