Item | Information |
---|---|
CAS RN | 78-32-0 |
Chemical Name | Tri-4-Tolyl phosphate |
Substance ID | R01-B-061 |
Classification year (FY) | FY2019 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2008 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
2 | Flammable gases | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
3 | Aerosols | * |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." |
4 | Oxidizing gases | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
5 | Gases under pressure | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
6 | Flammable liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
7 | Flammable solids | * |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | * |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)." |
9 | Pyrophoric liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
10 | Pyrophoric solids | * |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | * |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | * |
- |
- | - | It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 0.1 mg/L (25 deg C, isomer mixture) (HSDB (Access on July 2019)). |
13 | Oxidizing liquids | * |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
14 | Oxidizing solids | * |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to an element (P) other than carbon or hydrogen. However, the classification is not possible due to no data. |
15 | Organic peroxides | * |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." |
16 | Corrosive to metals | * |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. |
17 | Desensitized explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >128,000 mg/kg (NICNAS IMAP (Access on September 2019)) |
1 | Acute toxicity (Dermal) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | * |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
1 | Acute toxicity (Inhalation: Vapours) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance did not cause dermatitis when applied as a 10% solution to humans (ATSDR (2012)). |
3 | Serious eye damage/eye irritation | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Respiratory sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) There is no information on this substance. (2) As for in vivo tests with an isomer mixture including this substance, there is a negative result in an unscheduled DNA synthesis test with rat hepatocytes (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). (3) As for in vitro tests with an isomer mixture including this substance, there are negative results in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (NTP TR433 (1994), Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005), ATSDR (2012), ACGIH (7th, 2016)). |
6 | Carcinogenicity | * |
- |
- | - |
[Rationale for the Classification] There are no classification results by domestic and international organizations. There is no available report on humans. Though there are results on isomer mixture in (1), there are no data on this substance. Therefore, the classification was not possible. [Reference Data, etc.] (1) It was concluded that there was no evidence of carcinogenic activity because no incidence of treatment-related tumours was observed in tests in which an isomer mixture including this substance (this substance 4%) was administered by feed to rats and mice for 2 years (NTP TR433 (1994)). |
7 | Reproductive toxicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | * |
- |
- | - |
[Rationale for the Classification] Since (1) is the only information obtained for this substance, it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) In a test in which male rats were given 100 mg/kg/day (converted guidance value: 70 mg/kg/day, within the range of Category 2) of this substance by gavage for 63 days, decreased sperm concentrations were observed (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). (2) Tri-2-Tolyl phosphate (CAS RN 78-30-8), the ortho isomer of this substance, has strong neurotoxicity called OPIDN (organophosphate-induced delayed neuropathy), and it is known that this is a toxic effect from the metabolite, saligenin cyclic phosphate. However, the m, and p-isomers do not generate such cyclic phosphates and do not cause OPIDN (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). |
10 | Aspiration hazard | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.061 mg/L for fish (Lepomis macrochirus) (EHC 110, 1990). |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being rapidly degradable (a degradation rate by BOD: 100% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and 6-week NOEC = 0.01 mg/L for fish (Jordanella floridae) (EHC 110, 1990). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to 96-hour EC50 = 1.5 mg/L for algae (Scenedesmus pannonicus) (EHC 110, 1990) and a high bioaccumulation estimate (log Kow = 6.34 (KOWWIN)), although it is rapidly degradable (a degradation rate by BOD: 100% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)). By drawing a comparison between the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
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