Item | Information |
---|---|
CAS RN | 109-61-5 |
Chemical Name | Propyl chloroformate |
Substance ID | R01-B-023 |
Classification year (FY) | FY2019 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
2 | Flammable gases | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
3 | Aerosols | * |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." |
4 | Oxidizing gases | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
5 | Gases under pressure | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on a flash point of 26 deg C (closed cup) (ICSC (2005)). |
7 | Flammable solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
8 | Self-reactive substances and mixtures | * |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)." |
9 | Pyrophoric liquids | * |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 475 deg C (ICSC (2005)). |
10 | Pyrophoric solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
11 | Self-heating substances and mixtures | * |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | * |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." |
13 | Oxidizing liquids | * |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)." |
14 | Oxidizing solids | * |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
15 | Organic peroxides | * |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." |
16 | Corrosive to metals | * |
- |
- | - | No data available. Besides, there is information that no metal containers can be used (GESTIS (Access on June 2019)). |
17 | Desensitized explosives | * |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 4. [Evidence Data] (1) LD50 for rats: 1,210 mg/kg (SIDS (2012)) [Reference Data, etc.] (2) LD50 for mice: 650 mg/kg (PATTY (6th, 2012)) |
1 | Acute toxicity (Dermal) | * |
- |
- | - |
[Rationale for the Classification] Based on (1), it was not possible to specify the category. Therefore, classification was not possible due to lack of data. [Reference Data, etc.] (1) LD50 for mice: >10 mg/kg (PATTY (6th, 2012)) |
1 | Acute toxicity (Inhalation: Gases) | * |
- |
- | - |
[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (26,318 ppm), a reference value in units of ppm was applied as a vapor with little mist. [Evidence Data] (1) When rats were exposed to this substance at 1.019 mg/L (200 ppm) for 1 hour (converted 4-hour equivalent value: 0.51 mg/L (100 ppm), corresponding to the upper limit of Category 1) for 1 hour, 3/10 animals died (SIDS (2012)). Therefore, it was judged that the LC50 value was within the range of Category 2. [Reference Data, etc.] (2) LD50 (1 hour) for mice: 319 ppm (converted 4-hour equivalent value: 159.5 ppm) (PATTY (6th, 2012)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1B |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 1B. [Evidence Data] (1) In a skin corrosion test in which 0.5 mL of this substance was applied to two rabbits, it was corrosive, and persistent erythema, edema and necrosis were observed after 15-minute and 20-hour exposure (SIDS (2012), REACH registration dossier (Access on July 2019)). [Reference Data, etc.] (2) In a skin irritation test in which 0.5 mL of this substance was applied to rabbits under occlusive application for 24 hours, the mean scores of intact skins were 7.8 at 24 hours and 8.0 at 72 hours, and the mean scores of abraded skins were 8.0 both at 24 hours and 72 hours (SIDS Dossier (2012)). (3) It was classified as "Skin Corr. 1B (H314)" in the EU CLP classification (EU CLP classification (Access on July 2019)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
[Rationale for the Classification] Based on (1)-(5), it was classified in Category 1. [Evidence Data] (1) In an eye irritation test with rabbits similar to OECD TG 405 (dosage: 0.05 mL), it was corrosive. The mean scores at 24/48/72 hours were 3 for corneal opacity, 2 for iris, 1.8 for conjunctival redness and 2 for chemosis (SIDS (2012), SIDS Dossier (2012), REACH registration dossier (Access on July 2019)). (2) In an eye irritation test with rabbits by the Draize method, it was judged to be an extremely irritant. The symptoms were not reversible within 14 days (SIDS Dossier (2012)). (3) Direct contact with the rabbit eye causes permanent corneal opacity (PATTY (6th, 2012)). (4) It was classified in "Skin Corrosion (Category 1B)." |
4 | Respiratory sensitization | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | * |
- |
- | - |
[Rationale for the Classification] Though there is a description in (1), classification was not possible due to lack of data. [Reference Data, etc.] (1) Skin sensitization may occur (PATTY (6th, 2012)). |
5 | Germ cell mutagenicity | * |
- |
- | - |
[Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, a negative result was reported in a bacterial reverse mutation test (SIDS (2012)). |
6 | Carcinogenicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
7 | Reproductive toxicity | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on information on mucous irritation in humans in (1) and information that effects on the respiratory organs were observed at concentrations within the range of Category 1 in an inhalation exposure test with rats, it was classified in Category 1 (respiratory organs). The category was changed from the previous classification by the use of the new information sources. [Evidence Data] (1) As general information on humans, there is a description that the vapor of this substance was strongly irritating to the eyes and mucous membranes (PATTY (6th, 2012), HSDB (Access on June 2019)). (2) In a single inhalation exposure test with rats for 1 hour, by an exposure to a vapor of this substance at 1.019 mg/L (converted 4-hour equivalent value: 0.5095 mg/L, within the range of Category 1), dyspnea and mucosal irritation were observed, and 3 of 10 animals died within 6 days after the exposure. Acute pulmonary emphysema was observed at necropsy in rats exposed to 1.385 mg/L (SIDS (2012), SIDS Dossier (2012)). [Reference Data, etc.] (3) In a single oral dose test with rats, dyspnea, apathy, staggering and piloerection were observed in groups dosed at 681 mg/kg and 1,000 mg/kg, and 1 in 10 animals died in each group. Nine in 10 animals died in a group dosed at 1,470 mg/kg, and all animals died in groups dosed at 2,150 mg/kg and 3,160 mg/kg. At necropsy of the dead animals, necrotic white mucosa was observed in the stomach and intestine (SIDS (2012), SIDS Dossier (2012)). |
9 | Specific target organ toxicity - Repeated exposure | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
10 | Aspiration hazard | * |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 96-hour LC50 = 3.16 mg/L for fish (Danio rerio) (SIDS, 2012). |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (BIOWIN), and it was classified in Category 2 in acute toxicity. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
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