Item | Information |
---|---|
CAS RN | 5873-54-1 |
Chemical Name | 2,4'-Diphenylmethane diisocyanate |
Substance ID | H30-C-048-MHLW |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2013 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases (including chemically unstable gases) | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification is not possible due to lack of data. Although there is information of (2)-(4), it was not used for the classification because it is information on isomer mixtures. Besides, an isomer mixture of this substance was classified in Category 2B in serious eye damage/eye irritation (please refer to CAS: 26447-40-5), and 4,4'-isomer was classified in Category 2B (please refer to CAS: 101-68-8). [Reference Data, etc.] (1) It was classified in Eye Irrit. 2 in EU CLP. (2) Methylenediphenyl isocyanate (MDI) is known as an eye irritant (SIAR (2003), CICAD (2000)). (3) It is reported that in an eye irritation test with rabbits (OECD TG405, GLP-compliant, n = 3), after application of an undiluted isomer mixture containing this substance (2,2'-MDI: 0.64%, 2,4'-MDI: 53.60%, 4,4'-MDI: 45.72%), scores for corneal opacity, iris, conjunctival redness, and chemosis were 0 after 72 hours, and eye irritation was not seen (REACH registration dossier (Accessed Dec. 2018)). (4) It is reported that in an eye irritation test with rabbit (n = 6), after application of an undiluted this substance (MDI isomer mixture, purity 92-95%), macroscopic observation showed no immediate change in the cornea, moderate conjunctivitis was found after 24 hours, and four out of six animals recovered within seven days while conjunctivitis persisted in the other two (REACH registration dossier (Accessed Dec. 2018)). (5) As for methylenediphenyl isocyanate including 4,4'-isomer, skin disorders, anterior eye disorders, or respiratory tract disorders were designated as occupational diseases based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act. |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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