Item | Information |
---|---|
CAS RN | 334-88-3 |
Chemical Name | Diazomethane |
Substance ID | H30-C-037-MHLW |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases (including chemically unstable gases) | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] This substance is a strong irritant which causes damage to the respiratory organs even at lower concentrations (DFGOT Vol. 3 (1999)). Therefore, tests for carcinogenicity assessment are limited to short-time exposure tests, and classification results in (4) are reported from limited animal test results (1)-(3). From (4), the classification result by ACGIH, which classified later than IARC did, was prioritized, and the substance was classified in Category 1B. The category was revised by the use of new information sources. [Evidence Data] (1) As the result of inhalation exposure in male rats (total 13 animals) of two strains to the vapour from an ether solution of this substance (0.1-3.3 mg/L) for 2-3 minutes, twice weekly for six or 4.5 months, pulmonary adenoma was found in three out of seven animals which survived longer than 10 months, and one of these three showed squamous cell carcinoma of the lung which was invasive/metastatic to the diaphragm and skeletal muscle (IARC 7 (1974), DFGOT Vol. 3 (1999)). (2) As the result of inhalation exposure in male mice of the A strain (12 animals) to the vapour from an ether solution of this substance (0.1-3.3 mg/L) for about three minutes (reduced to two minutes after 10 days when deaths of animals occurred), twice weekly for six months, pulmonary adenoma was observed in 7/10 of mice which survived longer than six months (the control group: 2/8 animals). Moreover, as the result of inhalation exposure in male mice of the Swiss strain (five animals) to the vapour of this substance similarly generated for 1.5 minutes/time, 12 times in the first six weeks, lung tumors were observed in all the five animals which survived for six months (the control group: 3/6 animals) (IARC 7 (1974), DFGOT Vol. 3 (1999)). (3) After a few drops of an ether solution of this substance (0.1-3.3 mg/mL) were dermally applied on the dorsal skin of male mice of the A strain (12 animals) five times/week for five months, lung adenoma was observed in all the eight survived animals (IARC 7 (1974), DFGOT Vol. 3 (1999)). (4) IARC described there is limited evidence in experimental animals above and classified it in Group 3 (IARC Suppl. 7 (1987)). It is written in ACGIH that lung adenoma in mice and pulmonary adenoma and squamous cell carcinoma in rats were observed under condition similar to worker exposure, warrant to A2 designation for carcinogenicity classification (ACGIH (7th, 2001): classification in 1996). Other than these, it was classified in 1B in EU CLP. [Reference Data, etc.] (5) The Ministry of Health, Labour and Welfare judged that A2 classification by ACGIH is appropriate, and this substance is probably carcinogenic to humans (Hazard Assessment Table (Ministry of Health, Labour and Welfare, 2010)). |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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