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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10588-01-9
Chemical Name	Sodium dichromate
Substance ID	H30-C-032-MHLW
Classification year (FY)	FY2018
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2010 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Information on reproductive effects of this substance (sodium dichromate) does not exist for humans and is limited for experimental animals. However, because this substance is a water-soluble hexavalent chromium compound and is thought to act as hexavalent chromium in the body, it was judged that animal test data on potassium dichromate (CAS: 7778-50-9) could be used for classification. As for experimental animals, mating test results on a water-soluble hexavalent chromium compound (potassium dichromate) were: (1) as the result of oral dosing females followed by mating with untreated males, or oral dosing females during a gestation period, pre-or post-implantation deaths/resorptions of embryos/fetuses were markedly observed in both rats and mice, and live fetuses showed subdermal hemorrhage and malformations in the tail in addition to low body weight; (2) adverse effects on sexual function (copulation, ejaculation) were found in males; (3) possibilities of various reproductive toxicity effects by causing functional/mechanical adverse effects on the ovary in females were indicated. Besides, after repeated oral doses (by diet or drinking water) of this substance to male rats or potassium dichromate to male mice or monkeys, disorders of male genetic organs and spermatogenesis were observed as written in (4). As from the above, effects on fertility and developmental effects found in oral administration tests mainly on a potassium salt are thought to be applicable to this substance, however, knowledge on effects on humans by occupational exposure to hexavalent chromium is limited to (5). Therefore, this substance was classified in Category 1B. Besides, the classification result was revised by using information on a potassium salt and other compounds including this substance. [Evidence Data] (1) As the result of dosing female rats or mice with potassium dichromate for 20 days by drinking water followed by mating with untreated males, resorptions from pre-or post-implantation deaths of embryos/fetuses were evident, and live fetuses showed external anomalies such as subdermal hemorrhagic patches, kinky tails, and short tails in addition to low body weight and delayed skeletal formation. Moreover, also in a test in which pregnant mice were dosed with potassium dichromate by drinking water, subdermal hemorrhage and anomalies in the tails were found in fetuses at the maternal toxicity doses (CICAD (2013), ATSDR (2012), EU-RAR (2005)). (2) As the result of dosing male rats with potassium dichromate for 12 weeks by drinking water followed by mating with untreated females, a decreased number of mounts, lower percentage of ejaculating males, increased ejaculatory latency, and postejaculatory interval were observed as alterations in sexual behavior (CICAD (2013)). (3) As the result of dosing female rats with potassium dichromate for 20 days or 90 days by drinking water followed by mating with untreated males, decreases in female fertility index and male fertility index, increased pre-or post-implantation losses of embryos were found, and a decreased number of corpora lutea and extended or disturbed estrus cycles were observed in addition at the high doses. Moreover, as the result of dosing female mice with potassium dichromate for 20 days by drinking water, a reduction in the number of follicles at different stages of maturation, a decrease in the number of ovum/animal, histopathological alterations in the ovary (proliferated/dilatated blood vessels, pyknotic nuclei in follicular cells, atretic follicles) were observed (CICAD (2013), ATSDR (2012)). (4) Oral dosing male rats with this substance for 90 days caused testicular toxicity (histological/biochemical changes) and decreased spermatogenesis, and dosing male mice with potassium dichromate by diet for seven weeks caused degeneration in the seminiferous tubules, reduced sperm count, morphological defect of the sperms (CICAD (2013)). Moreover, in a test in male monkeys dosed with potassium dichromate for up to six months by drinking water, decreases in sperm count and motility were found after two months, and disrupted spermatogenesis and histopathological changes in the testis and epididymis (ductal obstruction, germ cell depletion, hyperplasia of the Leydig cells, Sertoli cell fibrosis) were observed after six months (ATSDR (2012)). [Reference Data, etc.] (5) It is reported in epidemiological surveys on sperm quality from occupational exposure to hexavalent chromium that increased rate of morphologically abnormal sperms, a decreased sperm count, and decreased sperm motility were observed (CICAD (2013), ATSDR (2012)). Besides, an increased incidence of toxicosis and complications during pregnancy and childbirth was reported among female workers of a dichromate production facility, however, the nature of the complications and toxicosis was not specified (CICAD (2013)). (6) In tests in which male rats were exposed to this substance for 90 days or six months by inhalation, anomaly in the testis was not observed. Besides, reproductive and developmental effects were not detected in a three-generation test with rats exposed to potassium dichromate by inhalation or other tests (CICAD (2013)). (7) As for the dihydrate of this substance (CAS: 7789-12-0), in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, at the dose where maternal animals showed general toxicity effects such as decreased food consumption and effects on the blood, stomach, and kidney, extension of gestation length was observed, but there were no effects on fertility, and effects on deliveries and offspring were not observed (JECDB (Accessed Jan. 2019)). (8) It was classified in Repr. 1B in EU CLP. Japan Society for Occupational Health (JSOH) classified chromium and its compounds in reproductive toxicants Group 3 (OEL Documentations (Reproductive toxicant classification) (Japan Society For Occupational Health (JSOH) 2014)).
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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