Item | Information |
---|---|
CAS RN | 85954-11-6 |
Chemical Name | 4,4'-Bis(2,3-epoxypropoxy)-3,3',5,5'-tetramethylbiphenyl (2,2'-((3,3',5,5'-tetramethyl-(1,1'-biphenyl)-4,4'-diyl)-bis(oxymethylene))-bis-oxirane) |
Substance ID | H30-B-027-MHLW, MOE |
Classification year (FY) | FY2018 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2007 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties (epoxides) present in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - |
[Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified" (Category 5 in UN GHS classification or equivalent to "Not classified"). Besides, the reliability rating was not given in (1)-(3) in the REACH registration dossier. [Evidence Data] (1) LD50 for rats (male): 3,563 mg/kg (REACH registration dossier (Accessed Oct. 2018)) (2) LD50 for rats (female): >5,000 mg/kg (REACH registration dossier (Accessed Oct. 2018)) (3) LD50 for rats: 5,728 mg/kg (REACH registration dossier (Accessed Oct. 2018)) |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 |
P302+P352
P362+P364 P280 P312 P321 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 4. Besides, the reliability rating was not given in (1) in the REACH registration dossier. [Evidence Data] (1) LD50 for rats: 2,000 mg/kg (REACH registration dossier (Accessed Oct. 2018)) |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - |
[Rationale for the Classification] Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. Besides, (1) was not adopted for classification since details of the test were unknown. [Reference Data, etc.] (1) There are two reports of no irritation in irritation tests (EU Method B.4, semi-occlusive application) with rabbits (REACH registration dossier (Accessed Oct. 2018)). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. Besides, (1) was not adopted for classification since details of the test were unknown. [Reference Data, etc.] (1) There are two reports that slight irritation was observed in eye irritation tests (EU Method B.5 (equivalent to OECD TG 405)) with rabbits (REACH registration dossier (Accessed Oct. 2018)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Reference Data, etc.] (1) There are reports that positive reactions in 12/20 animals and 9/20 animals, respectively, were observed 24 and 48 hours after application in one sensitization test (EU Method B.6) with guinea pigs, while positive reactions in 8/20 animals and 2/20 animals, respectively, were observed 24 and 48 hours after application in the other test (REACH registration dossier (Accessed Oct. 2018)). (2) There is a report that in a sensitization test (EU Method B.6) with guinea pigs, positive reactions were observed 24 and 48 hours after application in 8/20 animals, 0/20 animals, respectively (REACH registration dossier (Accessed Oct. 2018)). (3) It was classified as "Skin Sens. 1" in EU CLP. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for classifications by other organizations, it was classified in Carc. 2 by the EU, but the evidence is unknown. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - |
[Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
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