GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 60-29-7 |
| Chemical Name | Diethyl ether |
| Substance ID | H29-B-121 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 1 |
 Danger |
H224 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -45 deg C (closed cup), and a boiling point of 35 deg C (ICSC (J) (2002)), it was classified in Category 1. Besides, it is classified in Class 3, PGI in UNRTDG (UN 1155). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 175 deg C (GESTIS (Access on September 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to low-temperature-boiling liquids are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It is reported that LD50 values for rats were 1,215-2,540 mg/kg (DFGOT vol. 13 (1999)), 1.7 mL/kg (1,207 mg/kg) (PATTY (6th, 2012)), and 3,560 mg/kg (PATTY (6th, 2012)). One case corresponds to Category 4 to "Not classified," one case corresponds to Category 4, and one case corresponds to "Not classified" (Category 5 in UN GHS classification). By adopting the category with higher hazard, it was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of >20 mL/kg for rabbits (>14,200 mg/kg) (PATTY (6th, 2012)), it was classified as "Not classified." By using a new information source, the classification result was changed from the previous classification. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not classified |
- |
- | - | Based on reports of an LC50 value in a 4-hour inhalation test with rats of 32,000 ppm (PATTY (6th, 2012)), and an LC50 value in a 2.5-hour inhalation test with rats of 73,000 ppm (converted 4-hour equivalent value: 57,711ppm) (DFGOT Vol. 13 (1999)), it was classified as "Not classified." Besides, since the exposure concentrations are lower than 90% of the saturated vapor pressure level (710,053 ppm), the reference value in the unit of ppm was applied as vapor with little mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | There are descriptions that, in a skin irritation test with rabbits (non-occlusive application), it was not irritating (DFGOT Vol.13 (1999)), and that it is possible to be mildly irritating or no irritation was seen in a short duration (PATTY (6th, 2012)). Therefore, it was classified as "Not classified" (Category 3 in UN GHS classification) corresponding to mild irritation on the GHS classification guidance for the Japanese government. |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
For the two eye irritation tests with rabbits, there are descriptions that mild and reversible irritation was observed, and that mild eye irritation of grade 2 (maximum value 10) was observed (DFGOT Vol. 13 (1999)). In addition, there is a description that mild and reversible injury occurred in the eyes though test animals were unknown (PATTY (6th, 2012)). Therefore, it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that, in a sensitization test with guinea pigs, sensitization to this substance was not observed but the reliability of this test is questionable (DFGOT Vol. 13 (1999)). |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | There is no in vivo data. As for in vitro, bacterial reverse mutation tests gave negative or ambiguous results, and it was negative in a sister chromatid exchange test with mammalian cultured cells (DFGOT Vol.13 (1999), NTP DB (Access on September 2017)). From the above, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Category 2 |
 Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
There are reports that as a result of inhalation exposure in pregnant rats or mice during the organogenesis period, increased embryonic death, increased incidence of generalized edema (mouse), and reduced crown-rump lengths (rat) were observed. There is a report that as a result of inhalation exposure in pregnant rats during the early or late organogenesis period, early or late fetal resorptions and skeletal anomalies were observed. There is a report that cleft palate was seen when pregnant rats inhaled it during the organogenesis period, but this was not seen when pregnant mice were exposed (DFGOT Vol. 13 (1999), HSDB (Access on August 2017)). From the above, in many reports on developmental toxicity in experimental animals, obvious fetal toxicity and increases in the occurrence of malformations (in some reports) were observed in a situation where the presence or absence of maternal toxicity was unknown, therefore, it was judged as appropriate to classify the substance in Category 2 for this hazard class. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
As for humans, this substance has been used as an inhaled anesthetic since the middle 19th century (DFGOT Vol. 13 (1999), OEL Documentations (Japan Society For Occupational Health (JSOH), 1997)). There is a report that in a test with 10 volunteers, the subjects complained of irritation of the nasal mucosa after inhalation exposure at 200 ppm for 3 to 5 minutes (DFGOT Vol. 13 (1999), ACGIH (7th, 2001)). As for experimental animals, it is reported that in a single inhalation exposure test in mice (no description of exposure time), excitation and anesthesia were observed at 32,000 ppm, and the animals went under with deep anesthesia at 64,000 ppm, but recovered when the substance was removed from the atmosphere at the end of the exposure (PATTY (6th, 2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
As for humans, it is reported that loss of appetite, exhaustion, headache, sleepiness, dizziness, excitation, and psychic disturbances were caused by chronic exposure (ACGIH (7th, 2001)). As for experimental animals, in a 13-week oral dose toxicity test with rats, there was no effect at 500 mg/kg/day exceeding the guidance value range for Category 2, only weight loss was reported at or above 2,000 mg/kg/day (IRIS (1990)). From the above, since effects on the central nervous system were seen in humans, it was classified in Category 1 (central nervous system). Besides, in the previous classification, the neurological symptoms in humans were considered to be transient, therefore, they were not adopted as evidence for classification. However, they were adopted as evidence for classification this time by using new information sources and emphasizing occurrence of mental disorders. Therefore, the classification result was different from the previous classification. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, in the previous classification, it was classified in Category 2 using the information source in List 3, however, the evidence was not based on reports of cases in humans etc. but general remarks. Also, according to Japanese Industrial Standards (JIS) for GHS classification (JIS Z 7252: 2014) revised after the previous classification, a substance can be allocated to only Category 1, not Category 2, for this hazard class. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 96-hour LC50 = 2,560 mg/L for fish (Pimephales promelas) (NLM HSDB: 2014, EPA AQUIRE: 2017, Geiger, D. L. et al. (1986)), and 24-hour EC50 (immobile) = 165 mg/L for crustacea (Daphnia magna) (NLM HSDB: 2014, EPA AQUIRE: 2017, Bringmann, G. et al. (1982)), it was classified as "Not classified." |
| 11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Chronic toxicity data were not obtained. Due to being not rapidly degradable (non-biodegradable, a degradation rate by GC: 13% (J-CHECK, 1985)), and "Not classified" in acute toxicity, it was classified as "Not classified." |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |