GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 16961-83-4
Chemical Name Fluorosilicic acid
Substance ID H29-B-096
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - It is not combustible (ICSC (J) (2004)).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is not combustible (ICSC (J) (2004)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified
-
-
- - It is not combustible (ICSC (J) (2004)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It contains metalloids (Si), but it is estimated that it does not react vigorously with water from the observation result of being miscible with water (ICSC (J) (2004)).
13 Oxidizing liquids Classification not possible
-
-
- - The substance is an inorganic compound containing halogen (F) (but not oxygen), but the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - There is the information that it is corrosive to many metals (ICSC (J) (2004)), but the classification is not possible due to no data.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
Based on a report of an LD50 value of 430 mg/kg (HSDB (Access on August 2017)) for rats, this substance was classified in Category 4.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
Based on a description that this substance is corrosive to human skin (HSDB (Access on August 2017)), and a report that in an accident case in which this substance leaked from a tanker truck, more than 50 people in the neighborhood complaining of skin and respiratory tract irritation, etc., and that the driver of the truck who had his arm out from the window experienced burning on his forearm (HSDB (Access on August 2017)), this substance was classified in Category 1. Besides, this substance is classified as "Skin Corr. 1B" in EU CLP classification (ECHA CL Inventory (Access on August 2017)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Since it is classified in Category 1 for skin corrosion/irritation, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
Besides, for the genotoxicity of fluorine, it is stated by the Food Safety Commission of Japan that weak positive results were obtained in the in-vitro tests with mammalian cells, but in an in-vivo DNA damage test, it was judged negative in a comprehensive manner, and it was considered that there is no genotoxicity which is a particular problem for living bodies (Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)).
6 Carcinogenicity Classification not possible
-
-
- - Fluorides are classified in A4 by ACGIH (ACGIH (7th, 2001)). Therefore, it was classified as "Classification not possible."
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
As for humans, it is reported that this substance leaked out during a tanker truck accident in the United States and more than 50 neighboring residents went to hospital complaining of skin and respiratory irritation, burning sensation of the throat and headaches (HSDB (Access on August 2017)). In addition, there is a description that fluorides including this substance show irritation of the respiratory tract in ACGIH's "FLUORIDES" (ACGIH (7th, 2001)). From the above, this substance was classified in Category 3 (respiratory tract irritation).
Besides, ICSC and SITTIG which were used as information sources for the evidence for Category 2 (respiratory system, digestive system, central nervous system) in the previous classification are information sources in List 3 of the current guidance, and IUCLID (2000) could not be obtained and could not be confirmed, therefore, the information from these information sources was not used. In addition, as for the description in HSDB (2004) that this substance shows serious irritation of the lungs, nose, and throat, and causes severe damage in the throat and stomach, the source was found to be MSDS when HSDB (Access on August 2017) was confirmed, so it was not adopted. Therefore, the classification result was changed from the previous classification.
9 Specific target organ toxicity - Repeated exposure Category 1 (teeth, bone)


Danger
H372 P260
P264
P270
P314
P501
This substance is added to public water for the purpose of preventing dental caries (ATSDR (2003)). In humans, there is no information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluoride (ACGIH (7th, 2001)). In addition, for fluorides, both beneficial and detrimental dental and skeletal effects have been observed in humans. Fluoride has been shown to decrease the prevalence of dental caries and, under certain conditions, has been used for the treatment of osteoporosis. However, it is described that excess fluoride can also result in dental fluorosis and can result in an increased prevalence of bone fractures in the elderly or patients with skeletal fluorosis (ATSDR (2003)).
There is no information on this substance in experimental animals.
Therefore, this substance was classified in Category 1 (teeth, bone).
Besides, the classification differed from the previous classification because new information sources were used.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
From 96-hour LC50 = 13 mg/L [converted value 10.5 mgF/L] for crustacea (Mysidopsis bahia) (WHO EHC: 2002), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
Chronic toxicity data were not obtained. It is an inorganic compound, and the behavior in water is unknown. However, due to being soluble in water and acute toxicity Category 3, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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