GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 105-46-4 |
| Chemical Name | sec-Butyl acetate |
| Substance ID | H29-B-090 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
 Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 17 deg C (closed cup), and a boiling point of 112 deg C (ICSC (J) (2003)), it was classified in Category 2. Besides, it is classified in Cass 3, PGII, III in UNRTDG (UN 1123). |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 410 deg C (GESTIS (Access on September 2017)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There are 2 reports of LD50 values for rats of 4,100 mg/kg (ACGIH (7th, 2016)) and 3,200-6,400 mg/kg (DFGOT Vol. 19 (2003), CICAD 64 (2005), ACGIH (7th, 2016)). One corresponds to "Not classified" (Category 5 in UN GHS classification), and the other corresponds to "Not classified" (Category 5 in UN GHS classification) - "Not Classified." By adopting the category with higher hazard, it was classified as "Not classified" (Category 5 in UN GHS classification). The category was changed from the previous classification due to the revision of the GHS classification guidance for the Japanese Government. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of > 2,000 mg/kg (ACGIH (7th, 2016)) for rabbits, it was classified as "Not classified." The category was changed from the previous classification due to use of a new information source. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is a report that in a 6-hour inhalation exposure test with rats, all the animals survived at 3,500 ppm (converted 4-hour equivalent value: 4,287 ppm) (DFGOT vol. 19 (2003), CICAD 64 (2005), ACGIH (7th, 2016)), however, since it is not possible to identify the category from this result alone, it was classified as "Classification not possible." Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (13,198 ppm), a reference value in the unit of ppm was applied as vapour with little mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | There is a report that in a 4-hour inhalation exposure test with rats, all the animals died at 116 mg/L (24,360 ppm) exceeding the guidance value range of Category 4 (DFGOT vol. 19 (2003), CICAD 64 (2005), ACGIH (7th, 2016)). However, since it is not possible to identify the category from this result alone, it was classified as "Classification not possible." Besides, since the exposure concentration was lower than the saturated vapor pressure concentration (13,198 ppm), a reference value in the unit of mg/L was applied as mist. |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
Based on a description that this substance is irritating to the skin (HSDB (Access on August 2017)), it was classified in Category 2. The category was changed from the previous classification due to the revision of the GHS classification guidance for the Japanese Government. |
| 3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Based on descriptions that the liquid and the vapor of this substance were irritating to the eyes, and that in an eye irritation test with rabbits, butyl acetate (no description on the form of the isomers) caused a reversible damage of Grade 5 (highest grade 10) (both in PATTY (6th, 2012) and HSDB (Access on August 2017)), it was classified in Category 2. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There is a description that the vapor of this substance is irritating to the nose and throat (PATTY (6th, 2012), HSDB (Access on August 2017)). In addition, there is a report that in humans, nasal and eye irritation, headache and weakness were observed by inhalation exposure to this substance at 950 ppm for 30 minutes (PATTY (6th, 2012), HSDB (Access on August 2017)). While there is a report that anesthetic effects were not observed in humans even in inhalation exposure to 400-700 ppm of this substance for 2-3 hours (PATTY (6th, 2012), HSDB (Access on August 2017)), there is a report that severe overexposure may cause weakness, drowsiness, and unconsciousness (PATTY (6th, 2012), HSDB (Access on August 2017)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). As for effects on the central nervous system, in the previous classification, it was classified in Category 2 (central nervous system) and Category 3 (narcotic effects), however, since the effects were reversible, only Category 3 (narcotic effects) was adopted. Therefore, the classification result was changed from the previous classification. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. As for humans, there are descriptions that no reports are available for adverse effects on industrial workers (ACGIH (7th, 2001)), and that there are no reports of chronic systemic effects in humans (PATTY (6th, 2012)). As for experimental animals, no data on this substance were obtained. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |