GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 10102-43-9 |
| Chemical Name | Nitrogen monoxide |
| Substance ID | H29-B-089 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | Gas (GHS definition) |
| 2 | Flammable gases (including chemically unstable gases) | Not classified |
- |
- | - | It is not combustible (ICSC (J) (2015)). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Category 1 |
 Danger |
H270 |
P370+P376
P220 P244 P403 |
Oxygen equivalency coefficient is 0.3 (ISO 10156:2010), and it is classified in Category 1 in GHS classification guidance for the Japanese government. Besides, compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1660). |
| 5 | Gases under pressure | Compressed gas |
 Warning |
H280 | P410+P403 | It was classified as compressed gas from a boiling point of -151.74 deg C and a critical temperature of -92.9 deg C (HSDB (Access on August 2017)). Besides, compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1660). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | It is a gas according to the GHS definition. According to the GHS classification guidance for the Japanese government, the classification was changed from the previous classification. |
| 1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | It is a gas according to the GHS definition. According to the GHS classification guidance for the Japanese government, the classification was changed from the previous classification. |
| 1 | Acute toxicity (Inhalation: Gases) | Category 2 |
 Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
There were reports of LC50 values of 128 ppm and 854 ppm for rats (DFGOT (2014) (Access on August 2017)). However, these lacked descriptions of exposure time and could not be used as rationale. It was reported that 11 out of 20 animals died at 1,000 ppm (converted 4-hour equivalent value: 354 ppm) in a 30-minute single inhalation exposure test with rats (DFGOT (2014) (Access on August 2017)), suggesting that the LC50 value is in the vicinity of 354 ppm. Therefore, this substance was classified in Category 2. The data from RTECS (2004) used in the previous classification was not adopted this time because it could not be confirmed, and the details were unknown. By using a new information source, the category was changed from the previous classification. |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Gas (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there was a description that skin irritation was caused by the formation of nitric acid and nitrous acid from this substance (HSDB (Access on August 2017)), and a description that nitric acid was formed from nitrogen oxides and sweat, and caused skin burns (IPCS, PIM 283 (1992)). |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there was a description that eye irritation was caused by the formation of nitric acid and nitrous acid from this substance (HSDB (Access on August 2017)), and a description that fumes of nitrogen oxides cause eye irritation (IPCS, PIM 283 (1992)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There was no in vivo data. As for in vitro, this substance was positive in bacterial reverse mutation tests and mammalian-cell gene mutation tests (DFGOT (2014) (Access on August 2017)). Besides, with regard to the information sources cited in the previous classification, IUCLID was unavailable at the time of the current classification, and RTECS is the information source listed in List 3, therefore, both of these sources were not used. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it was reported that no carcinogenicity was observed in the lung when female mice were exposed by inhalation to this substance at a concentration of 2.4 ppm for 29 months (DFGOT (2014)) (Access on August 2017). However, this is a result from a study that was conducted at one dose level only and in which histopathological examination was performed on a small number of organs only. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (haemal system) |
 Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
As for humans, it was reported that in a 15-minute single inhalation exposure test with volunteers, a significant increase in the blood methemoglobin concentration was observed at 15 ppm or above (DFGOT (2014) (Access on August 2017)). As for experimental animals, it was reported that blood methemoglobin concentrations were increased to 60% following a 6-hour exposure at 322 ppm (converted 4-hour equivalent value: 394 ppm) in a single inhalation exposure test with mice, and that the animals developed cyanosis, and 11 out of 20 animals died following a 30-minute exposure at 1,000 ppm (converted 4-hour equivalent value: 354 ppm) in a single inhalation exposure test with rats (DFGOT (2014) (Access on August 2017)). Although blood methemoglobin concentrations were not measured in the latter study (with rats), the authors of the source article considered that the occurrence of cyanosis is the effect of methemoglobin formation on the basis of findings from a separate study with rats in which blood methemoglobin concentrations were increased to 65% or more after a 30-minute exposure at 1000 ppm. From the above, this substance was classified in Category 1 (haemal system). Besides, it is described that this substance is converted spontaneously to nitrogen dioxide (NO2, CAS RN 10102-44-0) (ACGIH (7th, 2001)). In the previous classification, the lung was adopted as the target organ based on a description in the ACGIH (7th, 2001) that the symptoms of acute pulmonary edema and cyanosis due to methemoglobin formation occurred in humans due to exposure to this substance. However, close examination of the ACGIH (7th, 2001) revealed that it was a description that by inhaling, as an anesthetic, a gaseous mixture of 75% nitrous oxide (N2O, CAS RN 10024-97-2) and 25% oxygen contaminated with more than 1.5% of this substance, two patients suffered from dyspnea and pulmonary edema attributed to nitrogen dioxide in addition to cyanosis and methemoglobinemia. The effect on the lung was therefore not considered to be caused directly by this substance and was not adopted this time. Therefore, the classification was changed. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There was no data showing the relationship between exposure to this substance alone and effects in humans. As for experimental animals, data were obtained from inhalation toxicity studies with rats, mice, rabbits, and dogs. However, while some of these data showed that an effect on respiratory tract irritation was observed at concentrations within the guidance value range for Category 2 (gas), others showed that no effect was observed (DFGOT (2014) (Access on August 2017)). Therefore, these data were not available for the classification. From the above, this substance was classified as "Classification not possible" due to a lack of data. |
| 10 | Aspiration hazard | Not applicable |
- |
- | - | Gas (GHS definition) |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |