GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | - |
| Chemical Name | Synthetic mineral fiber (except for RCF) |
| Substance ID | H29-B-087 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2009 FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (normal temperature) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (normal temperature) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (normal temperature) |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (normal temperature) |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (J) (2012)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (normal temperature) |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (J) (2012)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (J) (2012)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water from the observation result of being insoluble in water (HSDB (Access on September 2017)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (normal temperature) |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (normal temperature) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (normal temperature) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there are descriptions that although there are cases of workers who were exposed while manufacturing or handling rock/slag wool and had itching on the skin due to the physical stimulation, it was a temporary symptom, and could be managed by appropriate work (ACGIH (7th, 2001)) and often disappeared with continued exposure (EHC 77 (1988), ATSDR (2004)). In addition, there is a description that physical stimulation was caused mainly when the diameter of this substance was 5 micrometers or more (ACGIH (7th, 2001), ATSDR (2004)). The category was changed by revising the information content. |
| 3 | Serious eye damage/eye irritation | Category 2 |
 Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Based on descriptions that transient eye irritation was observed in workers who had inadequate protective measures (ACGIH (7th, 2001)), and that this substance is irritating to the eyes (ATSDR (2004)), and that exposure during handling of this substance was associated with eye irritation (EHC 77 (1988)), it was classified in Category 2. Since there was no information on the degree of the stimulation and on the recovery period, it was not sub-categorized. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data. As for in vitro, for the synthetic glass fiber (excluding RCF), glass wool, rock wool, and slag wool, there were negative or positive results in bacterial reverse mutation tests, chromosomal aberration tests and micronucleus tests with mammalian cultured cells, and sister chromatid exchange tests were negative (ATSDR (2004), EHC 77 (1988), IARC 81 (2002)). |
| 6 | Carcinogenicity |
Special-purpose wool (E-glass, 475-glass, etc.): Category 2 Continuous glass filament, insulation wool, rock (stone) wool, slag wool: Classification not possible |
 Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
IARC classified man-made vitreous fibers excluding RCF mainly into continuous glass filament, insulation wool, rock (stone) wool, slag wool, and special-purpose wool. Among these, as for continuous glass filament, insulation wool, and rock (stone) wool, evidence of carcinogenicity was insufficient in humans and limited in experimental animals, and as for slag wool, evidence of carcinogenicity was also limited in experimental animals, therefore, they were classified in Group 3 (IARC 81 (2002)). On the other hand, regarding the special-purpose wool including E-glass and 475-glass, in the tests with rats given by injection or implantation into the peritoneal cavity, intraperitoneal tumors were observed, and in the tests with rats or hamsters dosed intratracheally, lung tumors (both species) and mesothelioma (hamsters) were observed. Special-purpose wool was classified in Group 2B because there was sufficient evidence of carcinogenicity in experimental animals (IARC 81 (2002)). On the other hand, ACGIH classified continuous glass filament in A4, and insulation wool, rock (stone) wool, slag wool, and special-purpose wool were all classified in A3 (confirmed animal carcinogen) (ACGIH (7th, 2001)). However, it is considered that the evidence of carcinogenicity in experimental animals is weak (there was a positive data by the intraperitoneal administration, but it was negative on inhalation exposure). In addition, Japan Society For Occupational Health (JSOH) classified continuous glass filament, glass wool, rock wool, and slag wool in Group 3 (OEL Documentations (2003)). From the above, according to the classification results by IARC and JSOH, special-purpose wool were classified in Category 2, and continuous glass filament, insulation wool, rock (stone) wool, and slag wool were all classified as "Classification not possible." |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
As for humans, there is a description that symptoms of upper respiratory tract irritation such as nosebleed, cough, laryngeal and pharyngeal pain were observed after acute exposures to continuous glass filament, glass wool, rock wool, or slag wool. However, it is described that they disappeared rapidly following the cessation of exposure (ATSDR (2004)). Therefore, it was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
As for humans, it is described in EHC 77 (1988) that in some cross-sectional epidemiological studies, the possibility of the exposure-related effects of man-made mineral fibers (MMMF) on respiratory function was suggested; in a large-scale study, the prevalence of low profusion shadowing increased in chest radiographs of smokers with increasing lengths of employment in MMMF manufacturing; however, no consistent pattern of MMMF-related effects on the respiratory system has not been obtained from the cross-sectional studies to date. As for experimental animals, in tests in which rats were exposed by inhalation to rock wool (MMVF21) or slag wool (MMVF22) for 2 years, as for rock wool, within the guidance value range for Category 1, inflammation of the lung was observed at or above 3.1 mg/m3 (0.0031 mg/L), and mild pulmonary fibrosis was observed at or above 16 mg/m3 (0.016 mg/L). As for slag wool, although inflammation of the lung was observed at or above 3.1 mg/m3 (0.0031 mg/L) within the range of the guidance value for Category 1, pulmonary fibrosis was not observed even at the highest dose of 29.9 mg/m3 (0.03 mg/L) (ACGIH (7th, 2001), ATSDR (2004)). In addition, in a test in which rats were exposed by inhalation to glass wool (MMVF10, MMVF11) for 2 years, inflammation of the lung was observed at or above the dose (3.1 mg/m3 for MMVF10, 4.8 mg/m3 for MMVF11) within the range of the guidance value for Category 1. However, pulmonary fibrosis was not observed even at the highest dose (27.8 mg/m3 for MMVF10, 28.3 mg/m3 for MMVF11) (ATSDR (2004)). From the above, it was classified in Category 1 (respiratory organs). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |