GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 2489-77-2 |
| Chemical Name | Trimethylthiourea |
| Substance ID | H29-B-080 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2010 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Since the report of an LD50 value for rats of 316 mg/kg (RTECS (2008)) used in the previous classification is from the information source in List 3, the original source was not available, and the details are unknown, it was not adopted. Therefore, the classification result was changed. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, since the evidence in the previous classification, "Patients sensitized to ethyl butyl thiourea also reacted to this substance, and it is described as a sensitizer in Contact Dermatitis (Frosch) (4th, 2006)," could not be confirmed in Contact Dermatitis (Frosch) (5th, 2011), it was not adopted. Therefore, the classification result was changed. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no in vivo data. As for in vitro, a bacterial reverse mutation test was negative, a mouse lymphoma test with mammalian cultured cells was positive, and a chromosomal aberration test and a sister chromatid exchange test were negative (NTP DB (Access on July 2017)). |
| 6 | Carcinogenicity | Category 2 |
 Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
In carcinogenicity studies in which after a mixture of 80% of this substance and 15% of dimethylthiourea was administered by feeding to rats or mice, the observation periods of 29 weeks in rats and 14 weeks in mice were set, no sufficient evidence of carcinogenicity in male rats and female and male mice was shown. However, in female rats, a dose-relationship was observed in the incidence of follicular cell carcinomas of the thyroid and a combined incidence of follicular cell carcinomas and adenomas of the thyroid, and a significant increase was observed in the incidence (14/47 (30%)) of follicular cell carcinomas of the thyroid in the high dose group (500 ppm). Also, it was concluded that the test substance (a mixture of 80% of this substance and 15% of dimethylthiourea) showed carcinogenicity in female rats (NTP TR129 (1979), HSDB (Access on June 2017)). Other than these, there is no data available for the classification. From the above, although the mixture containing 80% of this substance was carcinogenic only to female rats, an increase in malignant tumors of the thyroid was observed at high frequency. Therefore, it was classified in Category 2 for this hazard class. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There is no information on this substance alone. Besides, as for a mixture of 80% of this substance and 15% of dimethylthiourea, 77-week toxicity tests with rats or mice dosed by feeding were conducted. No significant difference was shown in general symptoms, mortality, the incidence of non-neoplastic lesions, etc. as compared with the control group except that decreased body weight gain in female rats at 500 ppm (converted guidance value: 25 mg/kg/day) of the high dose group and decreased body weight gain in female and male mice at 1,000 ppm (converted guidance value: 150 mg/kg/day) of the high dose group were observed (NTP TR129 (1979)). Therefore, in mice, no adverse effect was observed at the dose of 150 mg/kg/day exceeding the upper limit of the guidance value range, and it corresponds to "Not classified" in the oral route. However, since there is no data on other routes, it was classified as "Classification not possible." |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 48-hour LC50 = 770 mg/L for crustacea (Daphnia magna) (EPA AQUIRE:2017, Maas,J.L.(1990)), it was classified as "Not classified." |
| 11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Chronic toxicity data were not obtained. Due to being not rapidly degradable (BioWin), and "Not classified" in acute toxicity, it was classified as "Not classified." |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |