GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 92-70-6
Chemical Name beta-Hydroxynaphthoic acid
Substance ID H29-B-078
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2009  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- - There is the information that it is combustible (ICSC (2010) (J)), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 400 deg C (ICSC (2010) (J)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501 		Based on the reports of LD50 values for rats of 823 mg/kg and 1,040 mg/kg (SIDS (2005)), it was classified in Category 4.
1 Acute toxicity (Dermal) Category 4


Warning
H312 P302+P352
P362+P364
P280
P312
P321
P501 		Based on a report that in an acute dermal toxicity test with guinea pigs, no lethality was found at 1,000 mg/kg, but death was at 2,000 mg/kg (SIDS (2005)), it is considered that the LD50 value should be in the range of 1,000-2,000 mg/kg (only one animal per dose was used in this study). Therefore, it was classified in Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321 		There is a description that irritation of the skin and respiratory tract may be caused in workers (SIDS (2005)). In addition, there is a report that in a skin irritation test (OECD TG 404 compliant) with rabbits, very slight erythema and edema were observed 1 hour and 24 hours after application of this substance, but these completely resolved within 48 hours, and the primary skin irritation index was 0.3. Also, there is a description that application of this substance for 24 hours caused mild to moderate irritation in a skin irritation test with guinea pigs (both SIDS (2005)). Based on the description of a possibility to cause skin irritation to workers, it was classified in Category 2. The information was reviewed, and the category was changed.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310 		Based on a report that in an eye irritation test (OECD TG 405 compliant) with rabbits, edema and conjunctival hyperaemia with secretions were observed 1 hour after application of this substance in all three animals, and conjunctivitis and corneal opacity, and iritis (one animal) were observed after 24-72 hours, with corneal erosion and vascularization observed in all animals after 7 days. These symptoms did not resolve until 14 days later at the end of the study (SIDS (2005)), it was classified in Category 1. The contents of the information source were reviewed, and the category was changed.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501 		Based on the result of a positive rate of 66.7% (6/9) 48 hours after a challenge in a modified maximization test (OECD TG 406 compliant) with guinea pigs (SIDS (2005)), it was classified in Category 1. Besides, results are reported that no sensitization was found in another maximization test (OECD TG 406 compliant) with guinea pigs and in a human patch test (SIDS (2005)). However, it is stated that it is impossible to make a final evaluation because of the small number of cases in both tests, particularly in the human patch test (28 healthy subjects, 8 dermatitis patients) (SIDS (2005)).
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, a micronucleus test with mouse bone marrow cells was negative, and a chromosomal aberration test with bone marrow cells of Chinese hamsters was negative (JECDB (Access on June 2017), SIDS (2005)). As for in vitro, bacterial reverse mutation tests were negative, and a mammalian cell chromosome aberration test was positive (SIDS (2005)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501 		In a one-generation study with rats orally dosed, in addition to lower values in body weight, external malformations such as kinked tail, brachyury and microphthalmos, and internal malformations such as abnormal position of the testes, hypoplasia of the spleen and diaphragmatic hernia were observed in the fetuses at the high dose (200 mg/kg/day) where decreased body weight gain was observed in parental animals in both sexes (JECDB (Access on June 2017), SIDS (2005)). From the above, since the occurrence of malformations was observed in the offspring at the dose of general toxic effects in parent animals, it was classified in Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity), Category 3 (respiratory tract irritation)



Warning
H371
H335 		P308+P311
P260
P264
P270
P405
P501
P304+P340
P403+P233
P261
P271
P312 		In humans, it is described that irritation of the skin and respiratory tract may be caused in workers (SIDS (2005)). As for experimental animals, there is a report that in a single oral dose test with rats, hypoactivity, abdominal position, lateral position, and diarrhea were found at 315 mg/kg/day or above, and at 1,000-1,250 mg/kg, in addition to these symptoms, tachypnea and eyelid closure were observed, and at necropsy of death cases, dark coloration and light-colored spots of the liver and hyperemia of the gastrointestinal tract were observed. An LD50 value of 823 mg/kg is reported in this test (SIDS (2005)). The dose where symptoms were observed correspond to Category 2 in the GHS classification guidance for the Japanese Government, but target organs cannot be identified with these symptoms alone. From the information above, it was classified in Category 2 (systemic toxicity), Category 3 (respiratory tract irritation). By adding the information on the respiratory tract irritation in humans, the classification result was changed from the previous one.
9 Specific target organ toxicity - Repeated exposure Category 2 (adrenal gland)


Warning
H373 P260
P314
P501 		No information is available on humans.
As for experimental animals, in a 28-day repeated oral dose toxicity test with rats, adrenal gland necrosis (one case) was observed in females at 60 mg/kg/day (converted guidance value: 18.7 mg/kg/day) within the guidance value range for Category 2, and at 300 mg/kg/day (converted guidance value: 93.3 mg/kg/day), increased water consumption, decreased phosphate level, increased bilirubin in the serum and urine in females and males, and increased liver weight and adrenal gland necrosis (one case) in females were observed (SIDS (2005)).
From the above, it was classified in Category 2 (adrenal gland). Besides, the classification result was different from the previous classification since adrenal gland necrosis was adopted as an effect.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501 		From 48-hour EC50 (immobile) = 32.9 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2004), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501 		If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 19.9% (J-CHECK: 1980)), and 72-hour NOEC (rate method) = 6.8 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 19.9% (J-CHECK: 1980)), and 48-hour EC50 (immobile) = 32.9 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2004).
From the above results, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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