GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 2451-62-9
Chemical Name 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione [Triglycidyl isocyanurate]
Substance ID H29-B-047
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- - It is described that it is combustible (ICSC (J) (1997)), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with self-reactive properties (strained ring) in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 200 deg C (ICSC (J) (1997)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501 		There are reports of LD50 values of 188-715 mg/kg (CICAD 8 (1998)) and 255-950 mg/kg (ACGIH (7th, 2001)) for rats, and both data correspond to Category 3-4. It was classified in Category 3 by adopting the category with higher hazard.
1 Acute toxicity (Dermal) Not classified
-
-
- - Based on the reports of LD50 values for rats of > 2,000 mg/kg (CICAD 8 (1998)) and > 3,100 mg/kg (ACGIH (7th, 2001)), it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Category 3


Danger
H331 P304+P340
P403+P233
P261
P271
P311
P321
P405
P501 		Based on a report of an LC50 value of 0.65 mg/L in a 4-hour inhalation test (dust) with rats (CICAD 8 (1998)), it was classified in Category 3.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321 		Based on a description that in a powder paint manufacturing plant in Australia, irritation such as rash on the skin was observed in 8 of 28 workers handling this substance (NICNAS (1994)), and based on a report that in a skin irritation test with rabbits, this substance showed irritation accompanied with slight erythema and edema (CICAD 8 (1998), ACGIH (7th, 2001), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), it was classified in Category 2.
3 Serious eye damage/eye irritation Category 2A


Warning
H319 P305+P351+P338
P337+P313
P264
P280 		Based on a description that in a powder paint manufacturing plant in Australia, eye irritation was observed in 8 of 28 workers handling this substance (NICNAS (1994)), and based on a report that in an eye irritation test with rabbits, moderate to severe corneal opacity, erythema and eye discharge occurred, but these resolved within 7 days after an application (NICNAS (1994)), it was classified in Category 2A. Besides, this substance is classified as "Eye Dam. 1" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501 		It is reported that in 2 cases of workers handling powder paint or pigment powder containing this substance, they did not have atopic diseases before exposure to this substance, however, developed coughing, wheezing, dyspnea, etc. after exposure due to painting work, and these were judged to be occupational asthma due to this substance because of a decrease in forced expiratory volume by the challenge test on this substance (NICNAS (2001)). Therefore, it was classified in Category 1.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501 		Based on a report that patients who developed contact dermatitis due to occupational exposure showed positive result in a patch test for this substance (ACGIH (7th, 2001), NICNAS (1994)), it was classified in Category 1. Besides, this substance is classified as "Skin Sens. 1" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). In addition, as for skin sensitization tests with guinea pigs, there are positive reports (CICAD 8 (1998), NICNAS (2001)) and negative reports (NICNAS (2001)) on the skin sensitization of this substance.
5 Germ cell mutagenicity Category 1B


Danger
H340 P308+P313
P201
P202
P280
P405
P501 		As for in vivo, it was negative in a dominant lethal test with mice, negative in a mouse spot test, positive and negative in chromosomal aberration tests with mouse spermatogonia, negative in a chromosomal aberration test with mouse spermatocytes, positive and negative in sister chromatid exchange tests with Chinese hamster bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 8 (1998), ACGIH (7th, 2001)). As for in vitro, it was positive in bacterial reverse mutation tests, a mouse lymphoma test, chromosomal aberration tests and a sister chromatid exchange test with mammalian cultured cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 8 (1998), ACGIH (7th, 2001)). From the above, since reproducibility of the positive results in the chromosomal aberration tests with mouse spermatogonia was confirmed, it was classified in Category 1B according to the GHS classification guidance for the Japanese government.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report that no increase in the tumors related to administration was observed in the test in which this substance was administered to male rats for a maximum of 99 weeks (10-100 ppm: the test finished at 63 weeks because of occurrence of death cases at the high dose of 300 ppm) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NICNAS (2001)).
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501 		In a test in which male rats were given this substance by feeding (10-100 ppm) for 9 weeks, then mated with females given normal feed, and the females had deliveries, no effect on male fertility and the development of fetuses and newborns was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), NICNAS (2001), CICAD 8 (1998)). On the other hand, in a test in which male mice were exposed by inhalation to the dust of this substance for 5 days and then mated with non-exposed females for 8 weeks, a depression in male fertility was observed in the third week for those exposed to 10 mg/m3, and in the third and the sixth week for those exposed to 50 mg/m3 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ACGIH (7th, 2001)).
From the above, in the two tests examining male fertility, no effect was observed through the oral route, however, a depression in male fertility was confirmed through the inhalation route. Therefore, because the effect on the male reproductive ability could not be denied, it was classified in Category 2 for this hazard class. Besides, the information source was limited to CICAD in the previous classification, it was expanded in this time, so the classification result was changed.
8 Specific target organ toxicity - Single exposure Category 1 (hematopoietic system, respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501 		There are an alpha type and a beta type of this substance, as for humans, alpha-triglycidyl isocyanurate, which is the alpha type, was expected to have an antitumor effect in the 1980s, and intravenous injections to cancer patients were reported, however, development was stopped because thrombophlebitis occurred at the injection region. As for the intravenous injection of alpha-triglycidyl isocyanurate, although the exact administration conditions such as the number of doses were unknown, it is reported that it was dosed with various conditions at up to 900 mg/kg, and that the toxic symptoms such as myelosuppression, nausea and vomiting were observed, and in rare cases, loss of hair and leukopenia were observed at high doses of 600 mg/kg or above (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
As for experimental animals, for a 4-hour single inhalation exposure test with dust of this substance, there is a report that slight inflammation of the nasal mucosa, and lung bleeding in dead animals were observed in rats (CICAD 8 (1998)), and there is a report that a decrease in locomotor activity, irritation of the eyes and respiratory organs, crust formation around the nose, eyes and mouth and discoloration of the lung were observed in mice (CICAD 8 (1998)). There are no detailed descriptions of the dose at which these effects were observed, however, it was reported that in these tests, an LC50 value for rats was 0.65 mg/L, which is within the guidance value range for Category 1, and an LC50 value for mice was 2.0 mg/L, which is within the guidance value range for Category 2, therefore, it is considered that the respiratory tract irritation and effects on the respiratory organs were observed in the vicinity of the LC50 values.
From the above, it is considered that the target organs of this substance were the hematopoietic system based on the information in humans, and the respiratory organs based on the information in experimental animals. Therefore, it was classified in Category 1 (hematopoietic system, respiratory organs). The classification result was changed from the previous classification by using the new information sources.
9 Specific target organ toxicity - Repeated exposure Category 1 (hematopoietic system), Category 2 (systemic toxicity)


Danger
Warning
H372
H373 		P260
P264
P270
P314
P501 		There are an alpha type and a beta type of this substance, as for humans, alpha-triglycidyl isocyanurate, which is the alpha type, was expected to have an antitumor effect in the 1980s, and intravenous injections to cancer patients were reported, however, development was stopped because thrombophlebitis occurred at the injection region. As for the intravenous injection of alpha-triglycidyl isocyanurate, it is reported that it was dosed with various conditions at up to 900 mg/kg, and that toxic symptoms such as myelosuppression, nausea and vomiting were observed, and in rare cases, loss of hair and leukopenia were observed at high doses of 600 mg/kg or above (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
As for experimental animals, in a 99-week repeated oral dose toxicity test with male rats by feeding, at 300 ppm (13.6 mg/kg/day) within the guidance value range for Category 2, the following is reported: a significant decrease in feed intake, a marked decrease in body weight gain (-68%), deterioration of general conditions, a decrease in the survival rate (56%, other group 90-96%), an increase in mast cells in the mesenteric lymph nodes (44/49), hemosiderin deposition (22/49), sinusoidal bleeding (24/49), a depletion of splenic lymphocyte-like cells, and an expansion of the intestinal tract (duodenum 32/44, jejunum 30/45, ileum 13/36) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
From the above, it was classified in Category 1 (hematopoietic system) based on the results in humans, and it was classified in Category 2 (systemic toxicity) based on the results in experimental animals.
The classification result was changed from the previous classification by using the new information sources.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - From 96-hour LC50 >77 mg/L for fish (Brachydanio rerio) (NICNAS PEC: 1994), it was classified as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Chronic toxicity data were not obtained. Due to being not rapidly degradable (non-biodegradable, average degradation rate by BOD: 0% (J-CHECK, 2002)), and "Not classified" in acute toxicity, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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