GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 95-85-2
Chemical Name 2-Amino-4-chlorophenol
Substance ID H29-B-021
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2009  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- - It is described that it is combustible (ICSC (J) (2006)), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with self-reactive properties (haloanilines) in the molecule, but because it is classified in Division 6.1, PGII in UNRTDG (UN 2673), it does not correspond to self-reactive substances and mixtures, hazard class with the highest precedence.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 500 deg C (ICSC (J) (2006)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- - It is an organic compound does not contain fluorine but contains oxygen and chlorine, amd the oxygen and chlorine are not chemically bonded to elements other than carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. The article (Cosmetic Ingredient Review Expert Panel (2004) Final report of the safety assessment, International Journal of Toxicology, 23 (Suppl. 2), 1-22.) which was used as evidence in the previous classification was consulted, but it was not possible to confirm the description of an LD50 value for this substance. In addition, although there is a description of an LD50 value of 650 mg/kg for rats in GESTIS (Access on June 2017) which is the information listed as List 3, this was not adopted because the original source was not obtained and the details were unknown. Therefore, the classification result was revised from the previous one.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. A positive result was obtained in the skin sensitization test with guinea pigs (Cosmetic Ingredient Review Expert Panel (2004) Final report of the safety assessment, International Journal of Toxicology, 23 (Suppl. 2), 1-22), but because the result was based on a test method not according to the test guideline, it was not adopted as evidence for the classification according to GHS classification guidance for the Japanese government.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it is positive in a bacterial reverse mutation test and a mammalian cell chromosome aberration test (Ministry of Health, Labor and Welfare, Results of Mutagenicity of Chemical Substances (Bacterial Test and CHL/IU Test, Access on June 2017), Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (1997), NTP DB (Access on June 2017)).
6 Carcinogenicity Category 2


Warning
H351 P308+P313
P201
P202
P280
P405
P501
In carcinogenicity studies with rats and mice dosed by feeding, as for the rats, increased incidences of squamous cell carcinoma and squamous cell papilloma of the forestomach and transitional epithelial carcinoma of the urinary bladder in males, and increased incidences of squamous cell papilloma of the forestomach in females were observed. As for the mice, increased incidence of squamous cell papilloma of the forestomach in males was observed, but no clear increase in tumor incidence was observed in females (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (Access on June 2017)). As the above, there was evidence of carcinogenicity in 2 species of experimental animals, but tumors observed in female rats and male mice were benign forestomach tumor, and there was no evidence of carcinogenicity for female mice. Therefore, it was decided to be appropriate to classify it in Category 2 for this hazard class.
7 Reproductive toxicity Classification not possible
-
-
- - In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422), no reproductive and developmental effects were observed at up to 250 mg/kg/day where effects on the blood and spleen were shown (Safety Test (Ministry of Economy, Trade and Industry (METI)) (Access on June 2017)). However, it was impossible to classify it as "Not classified" with only this result since this test is a screening test, and there are no other available data, therefore, classification was not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 2 (haemal system)


Warning
H373 P260
P314
P501
No information on humans is available.
As for experimental animals, there is a report that in a 90-day repeated dose toxicity test with rats dosed by feeding, at or above 1280 ppm (male: 72 mg/kg/day, female: 83 mg/kg/day) within the guidance value range for Category 2, a decrease in erythrocyte count, an increase in mean corpuscular volume, and an increase in reticulocyte percentage were observed, and at or above 3200 ppm (male: 184 mg/kg/day, female: 205 mg/kg/day) which exceeds the guidance value range for Category 2, hemosiderin deposition of the spleen, extramedullary hematopoiesis in the spleen, etc. were observed (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (Access on June 2017)). In addition, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422), there is a report that anemia findings, increased extramedullary hematopoiesis and hemosiderin deposition in the spleen, etc., increased hematopoietic cells of the born marrow, squamous cell hyperplasia at the limiting ridge of the forestomach, hyperplasia of the gastric pit epithelium of the glandular stomach, etc. were observed at 250 mg/kg/day (converted guidance value: 117 mg/kg/day) which exceeds the guidance value range for Category 2 (Safety Test (Ministry of Economy, Trade and Industry (METI)) (Access on June 2017)).
From the above, since anemia findings were observed within the guidance value range for Category 2, it was classified in Category 2 (haemal system).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

To GHS Information