GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 98-94-2
Chemical Name N,N-Dimethylcyclohexylamine
Substance ID H29-B-015
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2009  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
Based on a flash point of 42.2 deg C (closed cup) (ICSC (J) (2002)), it was classified in Category 3. It is classified in Class 8, Subsidiary risk 3, PGII in UNRTDG (UN 2264).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 215 deg C (ICSC (J) (2002)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501
There are 2 reports of LD50 values of 272-289 mg/kg (SIAP (2012)) and 348 mg/kg (PATTY (6th, 2012)) for rats. One corresponds to Category 3, and the other corresponds to Category 4. Since the category with higher hazard was adopted, it was classified in Category 3. The category was changed from the previous classification by using the new information source.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
Based on the reports of LD50 values of 370 mg/kg (PATTY (6th, 2012)) and 380 mg/kg (SIAP (2012)) for rats, it was classified in Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on the report of an LC50 value by 2-hour inhalation of 1900 mg/m3 (365.1 ppm, converted 4-hour equivalent value: 258.2 ppm) for rats, it was classified in Category 2. Besides, since the LC50 value is lower than 90% of the saturated vapor pressure concentration (3,960 ppm), the reference value in units of ppm was applied as vapour with little mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
Based on a report that it was corrosive in a skin irritation test with rabbits, and a description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this substance (SIAP (2012)), it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Based on a report that conjunctival injection, lacrimation, oedema of the conjunctiva and blepharospasm were observed in eye irritation tests with rabbits, and the description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this compound (SIAP (2012)), it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - There is a report that it is negative in a skin sensitization test with guinea pigs (PATTY (6th, 2012), GESTIS (Access on May 2017)), however, since the experimental conditions such as the number of animals were unknown, it was classified as "Classification not possible."
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by feeding, general toxicity and reproductive toxicity were not seen at up to the highest dose (1,500 ppm), and lowered body weight was observed in pups at the middle dose (500 ppm) or more (SIAP (2012)). The effect on pups was a minor one which is not regarded as evidence for classification. It is difficult to classify it as "Not classified" with only this result since this test is a screening test. It was classified as "Classification not possible" due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation)



Danger
Warning
H370
H335
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
There is no information on single exposure to this substance in humans. As for experimental animals, there are reports that in tests with rats, mice, rabbits and guinea pigs, weakness, tremor, salivation, gasping, and convulsions were observed in either the oral, dermal or inhalation routes, and adding to these symptoms, irritation of the respiratory organs was seen in inhalation exposure (PATTY (6th, 2012)). In these studies, although there is no detailed description of the dosage at which effects were observed, it is reported that the oral LD50 value is 320-620 mg/kg corresponding to Category 2, the dermal LD 50 value and the inhalation LC50 value (converted 4-hour equivalent value) are 370 mg/kg and 149.5-258.2 ppm, respectively, corresponding to Category 1; and it is considered that the effects were seen at doses near or at the LD50 values. In addition, in SIAP (2012), there is no detailed description of dosage in rats, but as toxic symptoms due to oral and dermal acute exposure to quaternary amines including this substance, effects on respiration, gait and standing posture, convulsions, tremor, ataxia, and lethargy were reported. Since the oral and dermal LD50 values of this substance for rats are reported to be 272-289 mg/kg and 380 mg/kg corresponding to Category 1, respectively (SIAP (2012)), it is considered that these effects were seen within the dose range for Category 1 near the LD50 values. From the above, this substance is considered to affect the central nervous system, and to be irritating to the respiratory tract. Therefore, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - There is no information on humans.
As for experimental animals, there is a report that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by feeding, neither systemic nor local toxicity occurred at 1500 ppm (male: 91-104 mg/kg/day (converted guidance value: 28-32 mg/kg/day), female: 85-147 mg/kg/day (converted guidance value: 26-46 mg/kg/day)), which is the highest dose for the test and is within the guidance value range for Category 2 (SIAP (2012)). However, since it is the highest dose in the test, the effect at any dose which exceeds this but is within the guidance value range, is unknown. Therefore, the classification was not possible.
In addition, in a 9-time inhalation exposure test with rats, there was a report of mild hyperplasia and hypertrophy of the nasal mucosa at 0.39 mg/L (SIAP (2012)). However, this was not adopted for classification because the exposure period was short and the exposure frequency was unknown.
From the above, classification was not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, based on the numerical data (viscosity: 1.16 mPa*s (25 deg C), density: 0.85 g/cm3 (20 deg C)) listed in GESTIS (Access on May 2017), the kinematic viscosity is calculated as 1.36 mm2/sec (25/20 deg C).

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
Although 72-hour EC50 (rate method) >2 mg/L for algae (Desmodesmus subspicatus) (OECD SIDS 2012), the toxicity value for the target substance is judged to be around 2mg/L due to 72-hour EC50 (area method) = 0.79 mg/L for algae. Therefore, it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (BIOWIN), and acute toxicity Category 2, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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