GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 7664-39-3
Chemical Name Hydrofluoric acid
Substance ID H29-B-006
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - Hydrofluoric acid which is the target of classification is a liquid (aqueous solution), and it was classified assuming that it was a liquid. Besides, please refer to the classification of "Hydrogen fluoride (anhydrate, practically gas)" having the same CAS RN.
There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - It is not combustible (ICSC (J) (2016)).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is not combustible (ICSC (J) (2016)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified
-
-
- - It is not combustible (ICSC (J) (2016)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible
-
-
- - The substance is an inorganic compound containing halogen (F) (but not oxygen), but the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - There is the information that it is corrosive to many metals (ICSC (J) (2016)), but the classification is not possible due to no data.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - The hydrofluoric acid intended here is liquid (aqueous solution), and classification was performed according to the assumption as liquid. Besides, please also refer to the classification of "hydrogen fluoride (anhydrate, practically gas)" with the same CAS registry number.

Classification not possible due to lack of data.
For the health hazard classes, please also refer to the classification of "sodium fluoride" (CAS RN 7681-49-4).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Since it is an aqueous solution and inhalation exposure to vapour is unlikely to occur, it was classified as "Not applicable." The classification result was changed from the previous classification.
Besides, as for hydrogen fluoride (anhydrate, practically gas), in 1-hour inhalation exposure tests with rats, six LC50 values of 0.792 mg/L (967 ppm, converted 4-hour equivalent value: 484 ppm) (EU-RAR (2001)), 1.069 mg/L (1,306 ppm, converted 4-hour equivalent value: 653 ppm) (EU-RAR (2001), PATTY (6th, 2012)), 1.138 mg/L (1,392 ppm, converted 4-hour equivalent value: 696 ppm) (EU-RAR (2001)), 1.317 mg/L (1,610 ppm, converted 4-hour equivalent value: 805 ppm) (ATSDR (2003)), 1.828 mg/L (2,233 ppm, converted 4-hour equivalent value: 1,117 ppm) (EU-RAR (2001)), and 1.909 mg/L (2,332 ppm, converted 4-hour equivalent value: 1,166 ppm) (EU-RAR (2001)) were reported. Of these, one corresponds to category 2, and five to Category 3, thus, this substance was classified in Category 3 to which the larger number of values corresponds.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
It is described that severe irritation or corrosivity of the skin was observed in contact with this substance (PATTY (6th, 2012), EU-RAR (2001), ATSDR (2003)), and it is reported that in a test (compliance with OECD TG 404) in which 5 mL of 5% aqueous solution of this substance was applied to rabbit skin for 4 hours, marked eschar formation was observed 24 hours after the exposure, and this did not disappear within 14 days (EU-RAR (2001)), therefore, this substance was classified in Category 1. Besides, it is classified as "Skin. Corr. 1A H314" in EU CLP classification (ECHA CL Inventory (Access on May 2017)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Based on the description that severe irritation of the eyes is produced in contact with this substance (PATTY (6th, 2012), EU-RAR (2001), ATSDR (2003)), this substance was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in the previous classification, the report that allergic dermatitis was observed in workers occupationally exposed to this substance (Chemical Substance Hazard Data (CERI, 2002)) was adopted as the rationale for the classification. However, this was not adopted as the rationale for classification because Chemical Substance Hazard Data (CERI) is the source of the information listed in List 3. Therefore, the classification was reviewed.
5 Germ cell mutagenicity Classification not possible
-
-
- - It could not be concluded from the results of in vivo tests with hydrofluoric acid (a mouse dominant lethal test, a mutual translocation tests with mouse testes, a chromosomal aberration test with rat bone marrow cells). It was described that evaluation was possible by tests with sodium fluoride (CAS RN 7681-49-4), which showed no chromosomal aberration. However, although abnormality was observed in anaphase cells, since fluoride ions do not bind to DNA covalently, and do not form DNA adducts, it is thought to be a secondary effect. Therefore, it is concluded that inorganic fluoride does not induce chromosomal damage in vivo (above EU-RAR (2001)). As for in vitro, a bacterial reverse mutation test was negative (DFGOT (2014) (Access on May 2017), EU-RAR (2001)). From the above, along with the GHS classification guidance for the Japanese Government, the substance was classified as "Classification not possible."
6 Carcinogenicity Classification not possible
-
-
- - Since fluorides are classified in A4 by ACGIH (ACGIH (7th, 2001)) and fluorides (inorganic, used in drinking water) are classified in Group 3 by IARC (IARC Suppl. 7 (1987)), it was classified as "Classification not possible." Besides, there is no test data of the substance itself. However, as for sodium fluoride (CAS RN 7681-49-4), there are reports of tests in which rats and mice were dosed by drinking water or dosed by diet. In a test with male rats dosed by drinking water, based on a small increase in the incidence of osteosarcoma observed, it was judged as equivocal evidence of carcinogenicity. Other than that, it was concluded that there was no evidence of carcinogenicity or that conclusions cannot be drawn because there was an inadequacy in test system (NTP TR393 (1990), EU-RAR (2001)).
7 Reproductive toxicity Classification not possible
-
-
- - There is no information on reproductive toxicity of this substance itself. However, it is considered that the information on fluorides, in particular sodium fluoride (CAS RN 7681-49-4) is available since this substance functions as free fluoride ions in vivo (EU-RAR (2001)). Both in a two-generation reproduction toxicity study with rats dosed by drinking water and in a developmental toxicity study with rats or rabbits dosed by drinking water, there were no effects or only minor effects that were not adopted as evidence of the classification at doses where maternal toxicity was manifested (EU-RAR (2001), DFGOT (2014) (Access on May 2017), ATSDR (2003)).
From the above, for sodium fluoride, obvious reproductive and developmental toxicity was not seen in the oral route, therefore, it could not be classified due to lack of data. As with sodium fluoride, this substance was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs, cardiovascular system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
In humans, 3 cases of exposure to this substance by dermal or inhalation due to accident were reported, and all had severe burns in the hands, face, etc. and developed respiratory insufficiency, hypocalcemia and arrhythmia, and died within 24 hours. Pulmonary edema was observed at the autopsy (ATSDR (2003), PATTY (6th, 2012)). Hypocalcemia is thought to be due to the binding of fluoride ions binding to calcium (PATTY (6th, 2012)). From the above, this substance was classified in Category 1 (respiratory organs, cardiovascular system). In the previous classification, based on the information that hemorrhage and necrosis of the pancreas were noted in humans (Chemical Substance Hazard Data (CERI, 2002)), the pancreas was adopted as the target organ. However, Chemical Substance Hazard Data (CERI) is the information source in List 3. In addition, as an effect on the pancreas was noted in only one case of accidental ingestion listed in ATSDR (2003), it is considered insufficient as evidence for classification, and it was not adopted as evidence of classification. Therefore, the classification result was changed from the previous classification.
Besides, in the information on hydrogen fluoride (anhydrate, practically gas), there is a report that in a single inhalation exposure test with rats, damage to the upper respiratory tract, respiratory distress, pulmonary congestion, and intra-alveolar edema were observed (EU-RAR (2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory organs, teeth, bone)


Danger
H372 P260
P264
P270
P314
P501
In humans, there is no information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluoride in ACGIH's "FLUORIDES" (ACGIH (7th, 2001)).
As for experimental animals, there is no information on this substance, but classification based on the toxicity of hydrogen fluoride is thought to be possible. There are multiple pieces of information on hydrogen fluoride. In a 91-day inhalation toxicity test (6 hours/day, 5 days/week) with rats, death, alopecia, hunched posture, depressed body weight, dental malocclusions, increases in the number of segmented neutrophils and platelets, a decrease in the numbers of red blood cells, a decrease in blood sugar, albumin and A/G-ratio, an increase in potassium and inorganic phosphorus, an increase in the relative organ weights of kidneys, liver, lung, testes, spleen, brain, heart and adrenals, and so on were observed at 7.52 mg/m3 (converted guidance value: 6.6 ppm), which is within the guidance value range of Category 1. There is a report that in a one-month inhalation toxicity test (6 hours/day, daily) with rats, damage to the dental enamel, atrophy and local edema of the bronchial mucosa, peribronchial hyperplasia, and irregularity of medullar cavities in the bones were observed at 1 mg/m3 (converted guidance value: 0.4 ppm), which is within the guidance value range of Category 1 (EU-RAR (2001)). In addition, in a five-month inhalation toxicity test (continuous exposure) with rats, central nervous system dysfunctions (decreased conditioned responses, increased latency until motor nerve response after stimulating) at or above 0.03 mg/m3 (converted guidance value: 0.12 ppm), which is within the guidance value range of Category 1, and histopathological changes in the nerve cell synapses at 0.1 ppm (converted guidance value: 0.4 ppm) are reported (ATSDR (2003)). Based on these data, this substance was classified in Category 1 (nervous system, respiratory organs, teeth, bone).
Besides, since the Chemical Substance Hazard Data (CERI, 2002) which was mainly used in the previous classification is an information source in List 3, it was not used. Therefore, the classification result was changed.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
From 96-hour EC50 (immobile) = 73.3 mg/L [converted value 38.28 mgF/L] for crustacea (Chaetogammarus marinus) (ECETOC TR91: 2003), it was classified in Category 3. Besides, the data of sodium fluoride was used for the classification.
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Although the behavior in water is unknown, due to water solubility of being freely miscible, 21-day NOEC (reproduction) = 7.1 mg/L [converted value 3.7 mgF/L] for crustacea (Daphnia magna) (NICNAS PEC: 2001, EU RAR: 2001), 72-hour NOEC (rate method) => 402 mg/L [converted value 210 mgF/L] for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017)), and 28-day NOEC (early life stage test) => 8.6 mg/L [converted value NaF: 9.9 mg/L] for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2017)), it was classified as "Not classified." Besides, the data of sodium fluoride was used for the classification.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

To GHS Information