GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7637-07-2
Chemical Name Trifluoroborane
Substance ID H29-B-003
Classification year (FY) FY2017
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Not classified
-
-
- - It is not combustible (ICSC (J) (1993)).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Classification not possible
-
-
- - No data available.
5 Gases under pressure Liquefied gas


Warning
H280 P410+P403 From a boiling point of -100 deg C (ICSC (J) (1993)), and a critical temperature of -12.25 deg C (Hommel (1991)), it was classified as high pressure liquefied gas. It is classified in Division 2.3, Subsidiary Risk 8 in UNRTDG (UN 1008).
6 Flammable liquids Not applicable
-
-
- - Gas (GHS definition)
7 Flammable solids Not applicable
-
-
- - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - Gas (GHS definition)
9 Pyrophoric liquids Not applicable
-
-
- - Gas (GHS definition)
10 Pyrophoric solids Not applicable
-
-
- - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable
-
-
- - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - Gas (GHS definition)
13 Oxidizing liquids Not applicable
-
-
- - Gas (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - Gas (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Gas (GHS definition)
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to gas substances are not available. Besides, there is the information that it attacks many metals when dissolved in water (ICSC (J) (1993)).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Dermal) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Inhalation: Gases) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on an LC50 value of 436 ppm for rats (ACGIH (7th, 2001), DFGOT Vol. 13 (1999), PATTY (6th, 2012)), this substance was classified in Category 2.
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable
-
-
- - Gas (GHS definition)
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
It is described that it is severely irritating or corrosive to human skin (ACGIH (7th, 2016), ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 1979)). In addition, this substance was classified as "Skin. Corr. 1A H314" in EU CLP classification (ECHA CL Inventory (Access on May 2017)). From the above, this substance was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Based on the description that it is severely irritating to human eyes (ACGIH (7th, 2016), OEL Documentations (Japan Society For Occupational Health (JSOH), 1979)), this substance was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, fluorides were classified in A4 by ACGIH (ACGIH (7th, 2001)).
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory organs, cardiovascular system)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
In humans, there is a description that this substance is irritating to the lungs and mucous membranes, and severe exposure leads to pulmonary inflammation and congestion and collapse of the circulatory organ system (cardiovascular system) (HSDB (Access on May 2017)). As for experimental animals, in a 4-hour single inhalation exposure test at 26.8 ppm, which is within the guidance value range for Category 1, ventral cartilage necrosis, hemorrhage, and ventral epithelial hyperplasia, and inflammatory cell infiltration in the larynx and trachea were observed in 24 hours after exposure (HSDB (Access on May 2017)). From the above, this substance was classified in Category 2 (respiratory organs, cardiovascular system). Since HSDB is an information source in List 2, it was classified in Category 2.
Besides, in the previous classification, based on the information that there is description of effects on the nervous system in human (hyporeflexia, drowsiness, syncope, decrease in blood pressure, hyperpnea and respiration depressed) (ICSC (J) (1993), HSDB (2005)), it was classified in Category 3 (narcotic effects). However, because there was no description of the above mentioned symptoms in ICSC (J) (1993), and the description of the above mentioned symptoms in HSDB (Access on May 2017) was not for this substance but for effects by oral ingestion of fluorides, it was not adopted. Since there is no other information on the evidence for narcotic effects, the classification result was changed.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs, kidney, bone)


Danger
H372 P260
P264
P270
P314
P501
In humans, there is no clear information on this substance. However, there is a report of lesions in bones related to fluorosis due to occupational exposure to inorganic fluorides in ACGIH's "FLUORIDES" (ACGIH (7th, 2001)).
As for experimental animals, though there is no reliable data on this substance, it is thought that data on the dihydrate are available. There is a report that in a 13-week (6 hours/day, 5 days/week) test in which rats were exposed by inhalation to the dihydrate (aerosol), rales, lacrimation and necrosis of the proximal tubules were observed at 17 mg/m3 (converted guidance value: 0.012 mg/L), which is within a guidance value range for Category 1 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 14 (Ministry of the Environment, 2016), PATTY (6th, 2012), ACGIH (7th, 2016)).
Besides, other than this, in humans, according to the survey results from health examinations started in 1974 for a small group (7 being exposed, 6 with exposure in the past) which had been exposed to this substance and other fluorides for 1 to 27 years in a manufacturing plant in USA, there is a report of a decrease in pulmonary function (vital capacity and 1-second volume) in 5 out of 7 being exposed and 3 out of 6 with exposure in the past, but it is reported that the X-ray examinations were negative, and no urinary fluorine concentration was above 4 mg/L which is an acceptable concentration at the end of a working time (HSDB (Access on May 2017)). In addition, in Soviet report (Summary Document) on 78 workers who had been exposed to this substance for 10 to 15 years, there is a report of dryness and bleeding of the nasal mucosa, bleeding gums, dryness and desquamation of the skin, and pain in joints. However, specific exposure concentrations were not reported and there was no report on the concentrations of ethylene and isobutylene that they were exposed to concurrently (HSDB (Access on May 2017)). This information was not adopted as evidence for classification because it is considered to be insufficient.
Therefore, this substance was classified in Category 1 (respiratory organs, kidney, bone).
As for the information on humans which was used in the previous classification, ICSC (J) (1993) is information sourced in List 3, the description in HSDB (2005) was not used for the classification because the content was confirmed and then found to be insufficient as described above, and IUCLID (2000) cannot be confirmed. Therefore, the classification result was changed.
10 Aspiration hazard Not applicable
-
-
- - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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