GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 7773-01-5 |
| Chemical Name | Manganese(II) chloride |
| Substance ID | H29-A-022 |
| Classification year (FY) | FY2017 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | New |
| Classification result in other fiscal year | |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | |
| Model SDS by MHLW (External link) | |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2017)). |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2017)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2017)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains metals (Mn), but it is estimated that it does not react vigorously with water from the measurement data of water solubility of 723 g/L (25 deg C) (GESTIS (Access on September 2017)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing chlorine, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Based on reports of LD50 values of 331 mg/kg (female), 342 mg/kg (male), 351 mg/kg (male), 412 mg/kg (male), 642 mg/kg (male) for rats (all of the data from ATSDR (2012)), this substance was classified in Category 4. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Although it is not the information on this substance, manganese salts are reported to be negative in the LLNA test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but the details are unknown. |
| 5 | Germ cell mutagenicity | Category 2 |
 Warning |
H341 |
P308+P313
P201 P202 P280 P405 P501 |
As for in vivo, this substance was positive in a micronucleus test with rat bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and the tetrahydrate of this substance (MnCl2 4H2O, CAS RN 13446-34-9) was negative in chromosome aberration tests with rat spermatogonial cells and bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), ATSDR (2012), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)). As for in vitro, this substance was positive in all of bacterial reverse mutation tests, a mammalian cell mouse lymphoma test and a chromosome aberration test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), ATSDR (2012), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)). From the above, this substance was classified in Category 2 according to the GHS classification guidance for the Japanese Government. |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | There is no data on this substance itself, but it was considered that the classification result of manganese chloride tetrahydrate (CAS RN 13446-34-9) which is a soluble manganese compound can be used. In the classification of manganese chloride tetrahydrate, it was classified as "Classification not possible" due to lack of data based on the following NTP's conclusion and no classification results for manganese compounds by other organizations (GHS classification results by the Japanese Government in FY2016); NTP concluded that there was no evidence of carcinogenicity in rats of both sexes in carcinogenicity tests with rats and mice given by feeding manganese sulfate monohydrate, a soluble divalent manganese compound, however, that there was equivocal evidence of carcinogenicity in mice, both sexes of which showed a slight increase in thyroid follicular cell adenoma. Therefore, this substance which is the anhydrate was also classified as "Classification not possible" in the same way. |
| 7 | Reproductive toxicity | Category 1B |
Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
There is no information on the reproductive effects in humans. As for experimental animals, dose-dependent teratogenesis (details unknown) was observed when this substance was given by gavage to pregnant rats throughout the gestation period, but no abnormality was observed by the administration in the organogenesis stage (CICAD 12 (1999)). In addition, in two tests in which this substance was intravenously administered to pregnant rats in the organogenesis stage and in a test in which manganese chloride tetrahydrate was administered subcutaneously to mice, increased frequency of skeletal abnormalities (skeleton of the whole body) was observed at or below the doses where maternal toxicity was manifested (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). Furthermore, in a test in which this substance was subcutaneously administered to mice on gestational day 6-18 at up to 2 mg/kg/day, at 2 mg/kg/day where there was no effect on the body weight of maternal animals, the survival rate of offspring was significantly decreased at postnatal day 4 and extension of time in eye opening and testicular descent was observed (OEL Documentations (Japan Society For Occupational Health (JSOH))). As for classifications by other organizations, Japan Society For Occupational Health (JSOH) classified manganese and manganese compounds in the reproductive toxicants Group 2 (OEL Documentations (2014)). As the above, on the basis that in experimental animals, although in tests of the injection route, increased frequency of skeletal abnormalities in the fetuses and decreased survival rates in the newborns were generally observed at or below the doses where the maternal toxicity manifested, and based on the classification result of Japan Society For Occupational Health (JSOH), this substance was classified in Category 1B. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
Although it is not the information on this substance, when humans are exposed to excess amounts of manganese by the oral or inhalation route, memory disorders, psychiatric symptoms, etc. were observed as acute effects, and as chronic effects, symptoms of manganese addiction similar to those of Parkinson's disease were seen, such as gait disturbance and speech disorders. Serious effects were observed especially in inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for the oral route, in cases of drinking well water containing high concentrations of manganese, and in epidemiological studies on residents living in regions with high manganese concentration, symptoms similar to manganese addiction such as mask-like faces, muscle rigidity, tremors and psychiatric disorders were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). The influence on the neurobehavioral function by exposure to the dust of manganese dioxide, trimanganese tetraoxide, and manganese salts (sulfate, carbonate, nitrate) in plants manufacturing manganese oxides and manganese salts was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). It is reported that neurotoxicity from manganese addiction due to occupational exposure to manganese dioxide was reported, and that in addition to decreases in visual simple reaction time and in eye-hand coordination, rigidity of the hands was observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). Furthermore, many case reports revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)). As for experimental animals, there is no information on this substance, but there is information on manganese chloride tetrahydrate (MnCl2 4H2O, CAS RN 13446-34-9, molecular weight 197.91). It is reported that in a 60-day repeated toxicity test with juvenile rats of 3 weeks old dosed by gavage, at 0.31 mg/kg/day corresponding to Category 1 (a converted value equivalent to this substance: 0.971 mg/kg/day, converted guidance value: 0.13 mg/kg/day), increased brain monoamine oxidase activity and neurodegeneration in the cerebral and cerebellar cortex and caudate nucleus were observed (ATSDR (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, in a 22-week toxicity test with rats dosed by drinking water, at 6.5 mg/kg/day (a converted value equivalent to this substance: 4.1 mg/kg/day), which is equivalent to Category 1, decreases in spatial memory capacity, open field locomotor activity and acoustic startle response, and increased latency of sensory evoked potentials were reported (ATSDR (2012)). Therefore, this substance was classified in Category 1 (nervous system, respiratory organs). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 48-hour EC50 = 4.6 mg/L [converted value 2.0 mg Mn/L] for crustacea (Daphnia magna) (WHO CICAD:2008), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 3 |
- |
H412 |
P273
P501 |
If chronic toxicity data are used, then it is classified as "Not classified" because metals are regarded to be non-biodegradable as elements although the behavior of a metal salt in water is unknown, and due to water solubility of 436,000 mg/L, 62-day NOEC (growth) = 6.4 mg/L [converted value 2.78 mg Mn/L] for fish (Salmo trutta) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)), and 21-day NOEC (reproduction inhibition) = 11.9 mg/L [converted value 5.2 mg Mn/L] for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 because metals are regarded to be non-biodegradable as elements although the behavior of a metal salt in water is unknown, and due to water solubility of 436,000 mg/L, and 24 to72-hour EC50 (rate method) = 11.1 mg/L for algae (Asterionella japonica) (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). From the above results, it was classified in Category 3. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |