GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 16090-02-1 |
| Chemical Name | Disodium 2,2'-vinylenebis[5-(4-morpholino-6-anilino-1,3,5-triazin-2-ylamino)benzenesulfonate] |
| Substance ID | H28-B-071, C-150B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC(J) (2006)). |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC(J) (2006)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Na), but it is estimated that it does not react vigorously with water due to the water solubility result of 5 mg/L (25 deg C) (HSDB (Access on October 2016)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (S, Na), but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 value (OECD TG 401) of > 5,000 mg/kg for rats (SIDS (2006)), the substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the LD50 value (OECD TG 402) of > 2,000 mg/kg for rats (SIDS (2006)), the substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is reported that in three skin irritation tests (according to EPA guidelines or FDA guidelines, 24-hour application) using rabbits, one test was negative and the substance was slightly irritating to the skin in two tests (SIDS (2006)). Therefore, the substance was classified as "Not classified." |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
It is reported that in three eye irritation tests (according to EPA guidelines or FDA guidelines) using rabbits, two tests were negative and the substance was slightly irritating in one test (SIDS (2006)). The substance was classified in Category 2B because SIDS concluded that this substance was slightly irritating to the eye (SIDS (2006)). |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Not classified |
- |
- | - | In a skin sensitization test using guinea pigs (Maximization test, OECD TG 406), no skin reaction was observed and sensitizing effects were not shown (SIDS (2006)). Moreover, this substance was negative in several human patch tests (SIDS (2006), Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)) and it was concluded that this substance was not a skin sensitizer (SIDS (2006)). Therefore, the substance was classified as "Not classified." |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Since it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government, the substance was classified as "Classification not possible." The results of micronucleus tests using bone marrow of mice or Chinese hamster in vivo tests were negative (SIDS (2006)). As for in vitro test, the results of bacterial reverse mutation tests and in vitro mammalian cell chromosome aberration tests were negative (SIDS (2006)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
No carcinogenic data available for humans. As for experimental animals, in a carcinogenicity test using rats given by feeding for 2 years, an increase in tumor incidences was not observed at up to 10,000 ppm (corresponding to 524 mg/kg/day for males, 791 mg/kg/day for females) (SIDS (2006)). However, it is not possible to classify the substance as "Not classified" from this result alone due to the absence of carcinogenicity test data in other animal species. Therefore, the classification of this substance was not possible due to lack of data. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in two pilot developmental toxicity studies using pregnant rats and rabbits no adverse effects on maternal animals and fetuses were observed at 1,000 mg/kg/day in both species (SIDS (2006)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There are no data on single exposure to this substance for humans. Besides, as for experimental animals, it is described that sedation, dyspnea, diarrhea, ruffled fur, and curved body position were observed at 2000 mg/kg or above in a single oral administration test using rats and that these effects were fully reversible, and that no gross lesions were found on dead animals (SIDS (2006)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
No data available for humans. As for experimental animals, in a 28-day repeated dose toxicity study using rats given by gavage, no effects were observed at the highest dose of 825 mg/kg/day (converted guidance value: 257 mg/kg/day) (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011), SIDS (2006)). Moreover, it is reported that in a 2-year repeated dose toxicity study by diet using rats, an increase in liver and kidney weights in males and ovary weights in females (no histopathological changes) were observed in a dose group of 1% (converted guidance value: 500 mg/kg/day), which is greater than Category 2 (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011), SIDS (2006)). Although the data in oral route is equivalent to "Not classified," the substance was classified as "Classification not possible" because no reports on other routes were available. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 48-hour EC50 = 6.85 mg/L for crustacea (Ceriodaphnia sp.) (SIDS, 2006), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
 - |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), and 21-day NOEC (reproduction) = 0.42 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because 96-hour LC50 for fish (Oryzias latipes) is > 44 mg/L (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997)), it is poorly water-soluble (water solubility = 5mg/L, PHYSPROP Database, 2009), and it is not rapidly degradable (BIOWIN) but estimated to be low bioaccumulative (log Kow = 1.48 (PHYSPROP Database, 2009)). It was classified in Category 2 by drawing a comparison between the above results. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |