GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 124-18-5 |
| Chemical Name | Decane |
| Substance ID | H28-B-062, C-128B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2009 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of 46 deg C (closed-cup) (ICSC(J) (1998)), it was classified in Category 3. Besides, it is classified in Class 3, PG III (UN 2247) in UNRTDG. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 210 deg C (ICSC(J) (1998)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, there is a reported LD50 value (OECD TG 401) of > 5,000 mg/kg for rats (ECHA Dossier (Access on January 2017)) which is equivalent to "Not classified." However, it is not possible to classify the substance based on only this value since the information source of the data is not on the List 1, List 2 and List 3. In addition, because IUCLID (2000) data used in the previous classification were not available, and details were unknown, it was not adopted as the evidence for classification. |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, because IUCLID (2000) data used in the previous classification were not available, and details were unknown, it was not adopted. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on the 2-hour LC50 value of 72.3 mg/L (converted 4-hour equivalent value: 36.2 mg/L) for mice (PATTY (6th, 2012)), this substance was classified as "Not classified." Besides, since the LC50 is higher than the saturated vapor pressure concentration (1,887.3 ppm (converted value: 11.0 mg/L)), a reference value in the unit of mg/L was applied as mist. |
| 2 | Skin corrosion/irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in skin irritation tests using rabbits (2 tests including the OECD TG 404 test), slight irritation was found (GESTIS (Access on September 2016)), therefore, it is thought that the test result was equivalent to "Not classified" (Category 3 of UN GHS classification). However, the details of the tests were unknown because the original literature could not be confirmed, and so on. Thus, it was not adopted as the evidence for classification. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in eye irritation tests using rabbits (2 tests including the OECD TG 405 test), irritation was very slight (maximum irritation index 1 for irritation of the conjunctiva after 24 and 48 hours) (GESTIS (Access on September 2016)), therefore, it is thought that this test result was equivalent to "Not classified." However, the details of the tests were unknown because the original literature could not be confirmed, and so on. Thus, it was not adopted as the evidence for classification. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There is no in vivo data. As for in vitro tests, a bacterial reverse mutation test was negative (NTP DB (Access on September 2016)). |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, in a study where the substance alone or in combination with Benzo[a]pyrene (BP) was applied to the skin of female mice for 440 days (3 times/week), skin papilloma was observed in 38 of 50 cases in the combination administration group (this substance 25 mg + BP 5 microg), while it was observed in 12 of 50 cases in the group of BP alone, and in 1 of 50 cases in the group of this substance alone. An increase in the incidence of papilloma in the combination group suggested that this substance might have promoter activity (NTP Summary of Data for Chemical Selection (Access on September 2016), PATTY (6th, 2012)). |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, no developmental and reproductive effects were observed both in parent and child animals at up to 1,000 mg/kg/day (SIAP (2012)). However, it is difficult to classify as "Not classified" based only on this screening test result, and no other data were available for classification. Therefore, the classification in this hazard class was not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. As for effects in humans, it is described that this substance shows asphyxia and causes central nervous system depression in very high concentrations (HSDB (Access on Sep 2016), PATTY (6th, 2012)). Since central nervous system depression might be due to oxygen deficiency, it was not used as a basis for classification. In addition, also in GESTIS (Access on September 2016) which is the information source on List 3, it is described that following high doses, symptoms of central nervous system depression could occur. However, no original literature was not available and no detail could be confirmed. There is no information available for the evidence of classification regarding experimental animals. Therefore, this substance was classified as "Classification not possible." |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There is no information on humans. As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, no effects were observed at the highest dose of 1,000 mg/kg/day (SIAP (2012)). In addition, in a 57-day (18 hours/day) toxicity study using rats administered by inhalation, decrease in the white blood cell count was observed at 540 ppm (3.14 mg/L) (converted guidance value: 5.97 mg/L), but no bone marrow changes or other organ changes were noted (PATTY (6th, 2012)). In a 50-week (3 days/week) study using mice administered dermally at doses of 0.1 to 0.15 g/animals, fibrosis of the dermis, pigmentation, and ulceration, and in a few cases kidney effects and lung hemorrhaging were observed (PATTY (6th, 2012)). However, these findings were seen at the doses outside the range of Category 2. Therefore, it was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Category 1 |
 Danger |
H304 |
P301+P310
P331 P405 P501 |
This substance is a hydrocarbon. Since its calculated kinematic viscosity value based on numerical data (viscosity: 0.838 mPa*s (25 deg C), density: 0.73 g/cm3 (20 deg C)) listed in HSDB (Access on September 2016) is 1.15 mm2/sec (25/20 deg C), this substance was classified in Category 1. Besides, it is described in GESTIS (Access on September 2016) that even if low doses of this substance are swallowed, there is a risk of serious lung damage as a consequence of aspiration. In addition, it is described that, in a test using rats, the aspiration of 0.2 mL of this substance caused death within 24 hours as a consequence of pulmonary edema (GESTIS (Access on September 2016)). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |