GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 1321-65-9
Chemical Name Trichloronaphthalene
Substance ID H28-B-053, C-098B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  It is combustible (ICSC(J) (2001)), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Classification not possible
-
-
- -  No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 Based on a 100% fatal dose (1,800 mg/kg) and a 100% survival dose (400 mg/kg) for guinea pigs (HSDB (Access October 2016)), it was classified in Category 4.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, strong dermal irritations were reported in guinea pigs dermally exposed to polychloronaphthalenes (CICAD 34 (2001)). However, this report was not adopted because this substance could not be identified as the cause of the irritation. Moreover, because the information adopted in the previous classification was from List 3 information sources and the original literature could not be confirmed, it was not adopted.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data. Besides, irritation of the eyes was reported in workers exposed to polychloronaphthalenes, but it was also suggested that there had been a possible exposure to other chemicals (CICAD 34 (2001)), therefore, this was not adopted. Moreover, because the information adopted in the previous classification was from List 3 information sources and the original literature could not be confirmed, it was not adopted.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data. There is no data on single exposure to this substance in humans and experimental animals. Besides, there are descriptions that chlorinated naphthalenes exhibit hepatotoxicity (CICAD 34 (2001), DFGOT vol. 13 (1997)) and a description that symptoms in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headaches, anaemia, haematuria, anorexia, vomiting, severe abdominal pain etc. (CICAD 34 (2001)). None of these, however, had information on number of exposure times.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, skin)


Danger
H372 P260
P264
P270
P314
P501
 There is no information with regard to this substance.
 Besides, for humans, severe skin reactions (chloracne) and liver disease have both been reported in occupational exposure to chlorinated naphthalenes (CICAD 34 (2001), DFGOT vol. 13 (1997), ACGIH (7th, 2001)). It is reported that the toxicity varies depending on the amount of chlorination, and that studies in humans and animals had shown that toxicity was dependent on the congener/isomer, and that there is agreement in all studies that the penta- and hexa- isomers were the most toxic (CICAD 34 (2001)).
 Among them, with regard to effects on the skin, it was reported that chloracne was observed with this substance and higher chlorinated naphthalenes (DFGOT Vol. 13 (1997)). It was reported that in the case of chloracne from use of this substance (usually mixed with some tetrachloronaphthalene), the incidence and severity were less than chloracne produced by penta- and hexachloronaphthalene (ACGIH (7th, 2001)). It was also reported that after dermal application to volunteers, only Halowax 1014, containing penta- and hexachloronaphthalenes, produced chloracne, and Halowaxes containing mono-, di-, tri-, tetra-, hepta-, and octachloronaphthalenes did not (CICAD 34 (2001)). With regard to effects on the liver, as information in which the substance is identified to some extent, a non-fatal case of hepatitis induced by occupational exposure to this substance (tetrachloronaphthalene was probably also present (CICAD 34 (2001)) at 3mg/m3 was reported (ACGIH (7th, 2001)). On the other hand, as for higher chlorinated congeners, it was reported that fatal cases of yellow atrophy of the liver occurred in workplace environments with concentrations of mixed pentachloronaphthalene and hexachloronaphthalene between 1 and 2 mg/m3 (ACGIH (7th, 2001)).
 As for experimental animals, in toxicity tests using rats by inhalation of this substance (with a small amount of tetrachloronaphthalene) for 2.5 months (1,232 hours) or 4 months (1,896 hours), very slight swelling of the liver at 0.0013 mg/L, which is within the range of Category 1, and hepatic hypertrophy and granulocytosis along with mitotic figures at 0.011 mg/L were observed (ACGIH (7th, 2001)).
 Besides, it was reported that in medium-term toxicity experiments performed with technical mixtures of polychloronaphthalenes in rats and guinea pigs, liver damage (mainly enlarged liver cells with increased granularity and vacuolization) etc. were found and the higher chlorinated mixtures appear to be more toxic (CICAD 34 (2001)).
 As described above, chlorinated naphthalenes affected the liver and skin, and pentachloronaphthalene which has five chlorine atoms and hexachloronaphthalene which has six chlorine atoms were thought to be the major causal substances for the toxicity of chlorinated naphthalenes. There is no information exclusively on this substance. However, it is thought that this substance which has three chlorine atoms, while considered to exhibit less toxicity, also has similar target organs. Therefore, this substance was classified in Category 1 (liver, skin).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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