GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 90-13-1
Chemical Name 1-Chloronaphthalene
Substance ID H28-B-052, C-096B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- -  Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- -  From a flash point of 121 deg C (closed-cup) (ICSC(J) (2008)), it corresponds to "Not classified."
7 Flammable solids Not applicable
-
-
- -  Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 558 deg C (ICSC(J) (2008)).
10 Pyrophoric solids Not applicable
-
-
- -  Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- -  Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
 Based on the LD50 value of 1,540 mg/kg for rats (CICAD 34 (2001)), the substance was classified in Category 4.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
 Based on the description that it is an irritant to the skin (HSDB (Access on October 2016)), the substance was classified in Category 2.
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
 Based on the description that it is an irritant to the eyes (HSDB (Access on October 2016)), the substance was classified in Category 2B.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 No in vivo data are available. As for in vitro data, bacterial reverse mutation tests were negative (CICAD 34 (2001)).
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
 There is no single exposure data for this substance in humans and experimental animals. Besides, it is described that chlorinated naphthalenes are hepatotoxic (CICAD 34 (2001), DFGOT vol. 13 (1997)) and that symptoms described in workers exposed to chlorinated naphthalenes included irritation of the eyes, fatigue, headaches, anaemia, haematuria, anorexia, vomiting, and severe abdominal pain (CICAD 34 (2001)). There is no information however on the frequency of exposure in each case. In the previous classification, the substance was classified in Category 2 (systemic toxicity) based on the description that "Symptoms of exposure to this substance may include, headaches, fatigue, vertigo and anorexia" (HSDB (2003)). However, the frequency of exposure was not clear, and it was not possible to refer to original information sources. Therefore, the classification was changed.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver)


Warning
H373 P260
P314
P501
 No data available for humans regarding this substance.
 As for experimental animals, in a 28-day repeated dose toxicity test using rats administered by gavage, a decrease in motor activity, crouching position, lower body weights (males), an increase in relative liver weights (females) and centrilobular hypertrophy of hepatocytes were observed at 100 mg/kg/day or above (converted guidance value: 31 mg/kg/day), which is equivalent to Category 2 (JECDB (Access on October 2016)). Moreover, higher value in ALT (males), gamma-GT (males) and absolute and relative liver weights etc. were observed at 300 mg/kg/day (converted guidance value: 93 mg/kg/day) (JECDB (Access on October 2016)).
 In the previous classification, the substance was classified in Category 2 (skin) based on the description in HSDB that "chloracne may develop after long term exposure" (HSDB (2003)). However, there was no description that chloracne was observed as a case of this substance, and it was described that chloracne was observed after exposure to trichloronaphthalenes and higher chlorinated naphthalenes (DFGOT vol. 13 (1997)). Therefore, skin was not adopted as the target organ.
 From the above, the substance was classified in Category 2 (liver).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
 From 96-hour LC50 = 0.69 mg/L for fish (Cyprinodon variegatus) (CICADs 34, 2001; ECETOC TR91, 2003), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
 If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), and 72-hour NOEC (r) = 0.07 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment), 2003).
 If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (Non-biodegradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), and 96-hour LC50 = 0.69 mg/L for fish (Cyprinodon variegatus) (CICAD 34, 2001; ECETOC TR91, 2003).
 It was classified in Category 1 from the above results.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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