GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 598-62-9
Chemical Name Manganese carbonate
Substance ID H28-B-051, C-092B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on July 2016)).
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is not combustible (GESTIS (Access on July 2016)).
11 Self-heating substances and mixtures Not classified
-
-
- -  It is not combustible (GESTIS (Access on July 2016)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- -  It contains a metal (Mn), but it is estimated that it does not react vigorously with water due to the water solubility data of 0.065 g/L measured (GESTIS (Access on July 2016)).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Classification not possible
-
-
- -  It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- -  It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- -  Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- -  Classification not possible due to lack of data. Additionally, although details are unknown, it has been reported that a manganese salt did not cause lymph node cell proliferation in a screening test for contact allergens using mice (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
 There is no data available for this substance itself, but data for inorganic manganese compounds may be available for classification. In a test in which manganese chloride tetrahydrate was subcutaneously administered to pregnant mice (Gestation days 6 to 15), at doses in which suppression of maternal weight gain and reduction in feed intake were observed in maternal animals or even at lower doses, increased embryo resorptions, renal hypoplasia, and wavy ribs were observed in fetuses (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). Also, in a test in which manganese chloride was intravenously administered to pregnant rats during organogenesis (Gestation days 6 to 17), fetal death, skeletal anomality, wavy ribs, bending of limbs were observed even at doses lower than that of the maternal toxicity (suppression of body weight gain, implantation number reduction) was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). In addition, it is also reported that increased exencephaly and embryo resorptions were observed in a single intraperitoneal administration of manganese sulfate to pregnant mice on the 8th day of gestation, and at higher doses, inhibition of implantation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, in a test in which manganese chloride was administered by drinking water to pregnant rats, throughout the pregnancy period, even at doses exceeding the expression of maternal toxicity (suppression of body weight gain, decrease in water intake), low body weight of the offspring was the only observation seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As described above, although it is limited to some extent, the toxicity information on the inorganic manganese compounds including this substance showed fetal toxicities such as fetal death, skeletal abnormalities, external malformation, and inhibition of implantation in the fetuses through injection routes such as subcutaneous, intravenous or intraperitoneal injection. Although weak as epidemiological evidence, on the basis of case reports of impotence or decreased libido observed in manganese addicts, and on the basis of embryotoxicity observed in studies using experimental animals, the Japan Society for Occupational Health classified manganese and its compounds in Group 2 of reproductive toxicity (OEL Documentations Vol.56 (Japan Society For Occupational Health (JSOH), 2014), Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2016)). Therefore, from the results of studies on inorganic manganese compounds using experimental animals, it was deemed appropriate to classify this substance in Category 1B for this hazard class.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
 No data is available for single exposure tests in humans or experimental animals. It is reported that single inhalation exposure to particles of manganese dioxide (CAS RN 1313-13-9), which is an insoluble manganese compound like this substance, lead to an inflammatory response in human lungs, and its symptoms were coughs, bronchitis, pneumonitis and reduction of lung function (CICAD 12 (1999)). Therefore, it is thought that this substance affects the respiratory organs in the similar manner to manganese dioxide. From the above, this substance was classified in Category 1 (respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
 It is reported that the water solubility of this substance is 8 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), and it is insoluble in water (HSDB (Access on August 2016)).
 As for humans, it is reported that in a production plant of manganese dioxide and manganese salt, exposure to manganese dioxide, manganese tetroxide, and manganese salts (sulfate, carbonate, nitrate) caused effects on neurobehavioral function (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). However, the relevance to this substance is unclear.
 As for experimental animals, there is not enough information available for the rationale of classification.
 However, the most common inorganic manganese substances are manganese dioxide, manganese carbonate, manganese silicate, and manganese trioxide. In general, it is indicated that exposure to excess manganese for 14 days or less (acute duration) or up to a year (intermediate duration) has an effect on the respiratory system and the nervous system, with no effect on other organ systems (CICAD 63 (2004), CICAD 12 (1999)). Also in humans, due to occupational exposure to manganese dioxide, insoluble manganese similar to this substance, occurrence of neurotoxicity due to manganese poisoning was reported and it was reported that in addition to deterioration in visual simple reaction time and eye-hand coordination, rigidity of the hands was observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). ATSDR (2012) examined the epidemiological research report in detail, and like the occupational exposure report at the above-mentioned alkaline battery plant, the neurological effects associated with prolonged low-level manganese exposure generally have been subtle changes including deficits in tests of neuromotor or cognitive functions and altered mood states. However, it is concluded that inhalation exposure to high levels of manganese compounds, mainly manganese dioxide, can lead to symptoms, which are mild initially but evolve to include dull affects, altered gait, fine tremors, and psychiatric disturbances (ATSDR (2012)). Also, many case reports reveal that respiratory disorders (coughs, bronchitis, pneumonia etc.) occur with manganese compounds mainly composed of manganese dioxide (ATSDR (2012)).
 From the above, this substance was classified in Category 1 (nervous system, respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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