GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 563-47-3 |
| Chemical Name | 3-Chloro-2-methyl-1-propene |
| Substance ID | H28-B-034, C-045B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
 Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
From a flash point of -12 deg C (closed-cup) and a boiling point of 72 deg C in ICSC(J) (2008), it corresponds to Category 2. Besides, it is classified in Class 3, PG II (UN2554) in UNRTDG. |
| 7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is an unsaturated bond (olefins) in the chemical structure, but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 540 deg C (ICSC(J) (2008)). |
| 10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - |
The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
There are 3 reported LD50 values for rats of 215 mg/kg (DFGOT vol.4 (1992), BUA 109 (1993)), 848 mg/kg (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)), and 1,240 mg/kg (DFGOT vol.4 (1992), BUA 109 (1993)). Since one value corresponds to Category 3, and two values correspond to Category 4, this substance was classified in Category 4 by adopting the Category which has larger number of reports. |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a reported LD50 value of > 4,000 mg/kg (DFGOT vol. 4 (1992)) for rats, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
 Danger |
H331 |
P304+P340
P403+P233 P261 P271 P311 P321 P405 P501 |
There are 2 reported LC50 values (4 hours) for rats of > 5,000 mg/m3 (converted value: >1,350 ppm) (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)) and 1,240 ppm (DFGOT vol.4 (1992), BUA 109 (1993)). One value corresponds to Category 4 ? "Not classified," and one value corresponds to Category 3. By adopting the more hazardous category, this substance was classified in Category 3. Besides, because the LC50 values are lower than 90% of the saturated vapor pressure concentration (136,520 ppm), the reference value in the unit of ppm was applied as vapour without mist. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 1 |
 Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It is reported to be corrosive to rabbit skin (DFGOT vol. 4 (1992)), and it is also reported to be irritating to the skin in humans (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). Therefore, it was classified in Category 1. |
| 3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | There is a report that it was not irritating to the rabbit eyes (DFGOT vol.4 (1992)). However, because there are no data other than this one report, this substance was classified as "Classification not possible." Besides, this substance was classified in Category 1 for Skin Corrosion/Irritation, and it was classified in Category 1 according to the latest GHS of the sixth revised edition despite the information on a negative finding. Therefore, it is thought that this substance will be classified in Category 1 when the GHS Classification Guidance for the Japanese Government is revised in accordance with the latest GHS. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
A sensitization test using guinea pigs was positive (DFGOT vol. 4 (1992)), and skin sensitization is also reported in humans (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). Therefore, this substance was classified in Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, the results were negative in micronucleus tests using mouse bone marrow cells, negative and positive in chromosomal aberration tests using mouse bone marrow cells, and negative and positive in sister chromatid exchange tests using mouse bone marrow cells (DFGOT vol.4 (1992), IARC 63 (1995), NTP DB (Access on June 2016)). However, the reproducibility of the positive results in the chromosomal aberration test and the sister chromatid exchange test were not confirmed (NTP DB (Access on June 2016)). As for in vitro, the results were positive and negative in bacterial reverse mutation tests, and in cultured mammalian cell tests, a mouse lymphoma assay was positive, a gene mutation test was negative, and chromosomal aberration tests and sister chromatid exchange tests were positive (DFGOT vol.4 (1992), IARC 63 (1995), NTP DB (Access on June 2016)). From the above, it is judged that the positive results seen in vitro are not induced in in vivo systems. |
| 6 | Carcinogenicity | Category 2 |
 Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
As for experimental animals, in carcinogenicity studies in which this substance was administered by gavage to rats and mice for 2 years, increases in the incidences of forestomach squamous cell papillomas and squamous cell carcinomas were observed in a dose-dependent manner in both rats and mice (NTP TR300 (1986)). In addition, in studies in which rats and mice were exposed to this substance by inhalation for 2 years, an increase in thyroid follicular adenoma in male rats, forestomach squamous cell papilloma in mice of both sexes, and an increase in Harderian gland adenomas in female mice were observed respectively (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on June 2016)). As for classifications by other organizations, IARC, which classified this substance in Group 3 in the previous evaluation, preannounced that the classification will be changed to Group 2B in the latest evaluation (IARC 115 (in prep, Access on June 2016)). Elsewhere, NTP classified it as R (NTP RoC (13th, 2014)) and Japan Society For Occupational Health (JSOH) classified in Group 2B (Recommendation of Occupational Exposure Limits (2015)). From the above, this substance was classified in Category 2 for this hazard class. |
| 7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
It is described that as the results that male rats were given this substance by gavage for 14 days, the presence of spermatids, spermatocytes, and spermatogonia in seminiferous tubules were observed, and sloughing of the germinal epithelium was suggested, however, the authors considered it was secondary effects caused by general toxicity (DFGOT vol. 4 (1992)). However, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using rats dosed by gavage, a decrease in the number of live pups at birth was observed at 180 mg/kg/day where effects on total bilirubin and liver enzymes (in females, details unspecified), an increase in post-implantation embryo loss, and forestomach epithelial hyperplasia were observed in the parental animals (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). In summary, an increase in embryo death and a decrease in the number of live pups at birth were seen at the dose where general toxicity in parental animals was manifested. Therefore, this substance was classified in Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
In humans, it is described that by exposure to high concentrations of vapors of this substance, the upper respiratory mucosa are irritated, and gasping, refusal to breathe, coughing, pain, lacrimation, and headache occur, and coma may occur rapidly, and that by inhalation at low vapor concentrations, central nervous depression and moderate irritation of the respiratory system occur (HSDB (Access on June 2016)). In addition, although detailed dosage was not described, it is described that in a single oral dose test using rats, staggering, ataxia, abdominal position, reduced body temperature, trembling, and breathing difficulties were observed (BUA 109 (1993)). From the above, this substance was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, in the previous classification, this substance was classified in Category 2 (central nervous system) on the basis of a description that ataxia, sedative effects, tremors, and dyspnea were observed in an acute oral toxicity test using rats, and the symptoms resolved after 96 hours (IUCLID (2000)). However, since IUCLID could not be obtained during the research for this classification, it was not adopted as the evidence of the classification. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs), Category 2 (haemal system, kidney) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
There is no information on humans. As for experimental animals, in 104-week studies using rats or mice exposed by inhalation, increased eosinophilic change in the respiratory epithelium at or above 50 ppm (0.19 mg/L), which is equivalent to Category 1, eosinophilic change and eosinophilic exudate in the olfactory epithelium, atrophy of the olfactory epithelium, and respiratory metaplasia of the olfactory epithelium at 100 ppm (0.37 mg/L) or above, which is equivalent to Category 2, and also forestomach hyperplasia at 200 ppm (0.74 mg/L) were reported. In a 13-week study using mice exposed by inhalation, effects on the stomach (hyperplasia of the forestomach mucosal epithelium) at or above 125 ppm (0.33 mg/L), which is equivalent to Category 2, and effects on the haemal system (a decrease in red blood cell count, etc.) at 250 ppm (0.67 mg/L) were reported (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on June 2016)). Besides, in a 2-week inhalation toxicity study (5 days/week, 10 exposures) using mice conducted by the same testing institution, atrophy and desquamation of the olfactory mucosa epithelium in the nasal cavity at or above 270 ppm (converted guidance value: 0.11 mg/L), which is equivalent to Category 1, and death, decreases in red blood cell count, hemoglobin concentration, and hematocrit value, increased ALT, increase in hepatic centrilobular nuclei basophilic change in the kidney, and necrosis of the adrenal gland at or above 810 ppm (0.33 mg/L), which is equivalent to Category 2, were observed (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, Access on June 2016)). However, as the test period was short, and there were effects that were not seen in the 13-week test or in the 104-week study, the results of the 2-week study were not adopted as the evidence of the classification. As for the oral route, in a 103-week repeated dose toxicity study using rats and mice by gavage administration, forestomach basal cell hyperplasia, inflammation of the nasal cavity, and nephropathy/nephrosis were observed in rats at 75 mg/kg/day, which is equivalent Category 2, and also in mice at 100 mg/kg/day, which is equivalent to Category 2 (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011), NTP TR300 (1986)). Of the above findings, the findings in the forestomach observed on both inhalation and oral routes were deemed to be due to irritation, thus, the forestomach was not regarded as a target organ. Therefore, this substance was classified in Category 1 (respiratory organs) and Category 2 (haemal system, kidney). The classification was changed from the previous classification because new information was obtained. |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the kinematic viscosity is calculated to be 0.46 mm2/sec (20 degC) using numerical data (viscosity: 0.42 mPa*s, density (specific gravity): 0.917 (20 degC)) listed in HSDB (Access on June 2016). |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 24-hour EC50 = 7.2 mg/L for crustacea (Daphnia magna) (BUA 109, 1993), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
 - |
H411 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (a degradation rate by BOD after 10 days: about 30 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and acute toxicity Category 2, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |