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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	22248-79-9
Chemical Name	(Z)-2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate [Tetrachlorvinphos]
Substance ID	H28-B-028, C-039B
Classification year (FY)	FY2016
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water due to the water solubility result measured (11 mg/L (20 deg C) (HSDB (Access on June 2016))).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen, but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	As LD50 values for rats, the following 6 values have been reported: 465 - 965 mg/kg (female), 1,480 mg/kg (male) (EPA TRED (2006)), 4,000 mg/kg (male), 9,100 mg/kg (female) (IARC 30 (1983)), 4,000 mg/kg (male), and 9,100 mg/kg (female) (Agricultural chemicals times supplement (1993)). Two values correspond to Category 4, and four values correspond to "Not Classified." Therefore, this substance was classified as "Not Classified," which had the largest number of values. The category was revised due to the revision of the GHS classification guidance for the Japanese Government. Besides, as for this substance, based on expert judgment, EPA TRED, IARC and Agricultural Chemicals Times supplement were preferentially adopted as the information source of LD 50 values.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	As LD50 values for rats, the following 2 values have been reported: > 10,000 mg/kg (gender unknown) (IARC 30 (1983)), > 10,000 mg/kg (male and female) (Agricultural Chemicals Times supplement (1993)). As an LD50 value for rabbits, the 1 value of > 2,000 mg/kg (gender unknown) (EPA TRED (2006)) has been reported. This substance was classified as "Not Classified" because all values correspond to "Not Classified." The category was revised due to the revision of the GHS Classification Guidance for the Japanese Government. Besides, as for this substance, based on expert judgment, EPA TRED, IARC and Agricultural Chemicals Times supplement were preferentially adopted as the information source of LD 50 values.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, as an LC50 value for rats, the one value of > 3.61 mg/L (gender unknown, exposure time unknown) (EPA TRED (2006)) has been reported, and as an LC50 value for mice, the one value of 1,500 mg/m3 (male, exposure time unknown) (Agricultural Chemicals Times supplement (1993)) has been reported. However, the exposure times are unknown in both reports, and the equivalent concentrations for 4-hour exposures cannot be calculated. Therefore, a category cannot be specified with these values.
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a description that slight irritation was exhibited in rabbits (EPA RED (1995)), this substance was classified as "Not classified" (Category 3 in UN GHS classification). The category was changed according to the GHS Classification Guidance for the Japanese Government.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In a primary eye irritation study using rabbits, moderate irritation (iritis and redness) was observed but resolved after three days (EPA RED (1995)). Therefore, this substance was classified in Category 2B. The category was changed in accordance with the GHS Classification Guidance for the Japanese Government.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In skin sensitization studies (2 studies including the Buehler test) using guinea pigs, sensitization was observed (EPA RED (1995)). In addition, in a maximization test using guinea pigs, positive results were observed in 17 out of 20 (Agricultural Chemicals Times supplement (1993)). Therefore, this substance was classified in Category 1. The category was changed in accordance with the GHS Classification Guidance for the Japanese Government.
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a micronucleus test using the bone marrow cells of mice is positive (HSDB (Access on June 2016)). As for in vitro, a bacterial reverse mutation test is negative, a chromosome aberration test and a sister chromatid exchange test using cultured mammalian cells are positive (EPA RED (1995), HSDB (Access on June 2016), Agricultural Chemicals Times supplement (1993)). From the above, this substance was classified in Category 2 in accordance with the GHS Classification Guidance for the Japanese Government.
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	There is no information in humans. As for experimental animals, there are reports that in 80-week feeding administration to mice, an increase in hepatocellular tumors (males and females) was observed, and that in feeding administration to rats in a similar manner, an increase in adrenal cortical adenomas in addition to an increasing trend of C-cell adenoma of the thyroid (in females) were observed. On the other hand, there is a report that in a separate 2-year study using rats dosed by feeding, an increase in tumor related to the administration of this substance was not observed (IARC 30 (1983)). IARC had formerly classified this substance in Group 3 (IARC Suppl. 7 (1987)), but they changed the classification to Group 2B since in the latest evaluation, the evidence of carcinogenicity in experimental animals is sufficient (IARC 112 (in prep., Access in June 2016)). Therefore, the substance was classified in Category 2 for this hazard class.
7	Reproductive toxicity	Classification not possible	- -	-	-	In two-or three-generation reproductive toxicity studies (three studies) by diet administration to rats, even at doses at which decreased weight gain was observed in parental animals, adverse effects on fertility were not found (HSDB (Access on June 2016)). On the other hand, it is written that in a developmental toxicity study using pregnant rats administered by gavage, no effects were observed in fetuses even at the doses of maternal toxicity, however, that in a developmental toxicity study using pregnant rabbits, an increase in embryo/fetal resorptions was observed at doses at which decreased weight gain was observed in the dams (HSDB (Access on May 2016)). From the above, developmental effects in rabbits are not negligible, but the substance was classified as "Classification not possible" because it was judged that data is insufficient to assign a category.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In humans, this substance may inhibit cholinesterase, stimulate the nervous system excessively, cause nausea, dizziness and confusion, in addition, may cause respiratory paralysis and death in cases of severe exposure such as accidents and severe leakage (HSDB (Access on June 2016)). Also organophosphate insecticides including this substance, in general, inhibit the acetylcholinesterase in the nervous system. It is described that symptoms occurring by accumulation of acetylcholine include headaches, dizziness, and weakness in mild cases, nausea, salivation, lacrimation, bronchorrhea, diarrhea, vomiting, and muscular fasciculations in moderate cases, and miosis, dyspnea, pulmonary edema, cyanosis, convulsions, coma, bradycardia or tachycardia, cardiac ischemia, and cardiac dysrhythmia in severe cases (IPCS, PIM 001 (1989)). From the above, this substance was classified in Category 1 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system)	Warning	H373	P260 P314 P501	As for humans, there is no report on effects, but it is reported that as the result of daily administration to volunteers at up to 15 mg, no effects on cholinesterase activity in plasma and red blood cells were seen (IARC 30 (1983)). On the other hand, in general, it is said that the toxicological effects of the organophosphorus pesticides are almost entirely due to the inhibition of acetylcholinesterase in the nervous system (PIM G001 (1989)). There is a description that this substance may cause cholinesterase activity inhibition in humans (EPA TRED (2006)). As for experimental animals, in a 13-week repeated dose toxicity test using rats by feeding, at 2,000 ppm (males: 43.2 mg/kg/day, females: 62.7 mg/kg/day), which is equivalent to Category 2, reduced cholinesterase activity in plasma and red blood cells, basophilic tubules (males), increased fat deposition in the adrenal cortex (females), centrilobular hepatocellular hypertrophy (only at 2,000 ppm in males) and thyroid follicular cell hypertrophy were observed (EPA RED (1995)). Besides, with regard to the adrenal gland, liver and thyroid, they were not adopted as evidence for classification because of the concern that they were adaptive responses or secondary findings, etc. As described above, the possibility to cause cholinesterase activity inhibition is suggested in general in spite of no data on humans and cholinesterase activity inhibition is reported in the experimental animals. Therefore, this substance was classified in Category 2 (nervous system).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	From LC50 (unknown time) = 1.9 ppb for crustacea (Daphnia magna) (U.S.EPA: RED, 1995), it was classified in Category 1.
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (a degradation rate by BOD: 0 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1986)), and acute toxicity Category 1, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.

NOTE:

* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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