GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 85-42-7
Chemical Name Hexahydrophthalic anhydride
Substance ID H28-B-014, C-021B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  There is the information of combustible (ICSC (2006)), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 450 deg C (GESTIS (Access on May 2016)).
11 Self-heating substances and mixtures Not applicable
-
-
- -  Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Solid (GHS definition).
14 Oxidizing solids Not applicable
-
-
- -  The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  It is a substance with a melting point of 55 deg C or lower, but the classification is not possible due to no data.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on the LD50 values for rats of 2,700 to 2,800 mg/kg (ACGIH (7th, 2015), HSDB (Access on May 2016)) and 4,040 mg/kg (HSDB (Access on May 2016)), the substance was classified as "Not classified" (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified
-
-
- -  Based on the LD50 value of >2,000 mg/kg for rabbits (HSDB (Access on May 2016)) and the report that no rabbits died at 2,000 mg/kg (ACGIH (7th, 2015)), the substance was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
 Besides, it is reported that LC50 value for rats is > 1,100 mg/m3/4h (ACGIH (2015)), however, the classification is not possible because the category cannot be determined. According to the GHS classification guidance for the Japanese government, the category was changed.
2 Skin corrosion/irritation Not classified
-
-
- -  As it was described that this substance was found to be irritating according to the Draize test on rabbits (ACGIH (7th, 2015)), and that score is 0.92 (minimal to slight irritation) in the original literature, it was judged as slight irritation. Therefore, the substance was classified as "Not classified" (Category 3 in UN GHS classification).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
 It is reported that workers developed conjunctivitis from exposure to this substance existing in the air at the plant (ACGIH (7th, 2015)), and it was described that although severe but reversible irritation was observed in a Draize test using rabbits, it was classified as a corrosive (ACGIH (7th, 2015)). Therefore, the substance was classified in Category 1.
 Besides, this substance is classified as "H318 Eye Dam. 1" in EU CLP classification (ECHA C&L Inventory (Access on May 2016)).
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501
 There are several reports that workers handling this substance developed IgE- or IgG-mediated hypersensitivity (including rhinitis, asthma), and 8 out of 13 workers had positive reactions in the skin-prick test (ACGIH (7th, 2015)). Therefore, the substance was classified in Category 1.
 Besides, this substance is classified as "H334 Resp. Sens. 1" in EU CLP classification (ECHA C&L Inventory (Access on May 2016)).
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
 In human case, there was a case report that a worker developed contact urticaria from dermal exposure to this substance (ACGIH (7th, 2015)). Therefore, the substance was classified in Category 1.
 Besides, this substance is classified as "H334 Resp. Sens. 1" in EU CLP classification (ECHA C&L Inventory (Access on May 2016)).
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 No in vivo data are available. As for in vitro data, a bacterial reverse mutation test was negative (ACGIH (7th, 2015), HSDB (Access on May 2016)).
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (respiratory tract irritation, narcotic effects)


Warning
H335
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
 It was reported that in humans this substance caused anemia, headache, fever and dizziness in addition to transient irritating effects on skin, eyes, and the respiratory tract (HSDB (Access on May 2016)). Moreover, it was reported that in humans the irritative symptoms (itching, lacrimation, sneezing, rhinorrhoea, cough, and dyspnoea) begin immediately following exposure to high concentrations of dusts or vapours of cyclic acid anhydrides (CICAD 75 (2009)). Therefore, the substance was classified in Category 3 (respiratory tract irritation, narcotic effects).
 Besides, it is reported that decreased activity was observed in single dose tests by oral or inhalation in rats (HPVIS (Access on July 2016)), but the information was not adopted for the evidence of classification because it is not designated information source in the GHS classification guidance for the Japanese government.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

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