GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 85-43-8
Chemical Name Tetrahydrophthalic anhydride
Substance ID H28-B-012, C-019B
Classification year (FY) FY2016
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- -  There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- -  Solid (GHS definition).
3 Aerosols Not applicable
-
-
- -  Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- -  Solid (GHS definition).
5 Gases under pressure Not applicable
-
-
- -  Solid (GHS definition).
6 Flammable liquids Not applicable
-
-
- -  Solid (GHS definition).
7 Flammable solids Classification not possible
-
-
- -  There is the information that it is a combustible solid (Hommel, 1991), but the classification is not possible due to no data.
8 Self-reactive substances and mixtures Not applicable
-
-
- -  There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- -  Solid (GHS definition).
10 Pyrophoric solids Not classified
-
-
- -  It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 450 deg C (ICSC(J) (2001)).
11 Self-heating substances and mixtures Classification not possible
-
-
- -  Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- -  The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- -  Not applicable
14 Oxidizing solids Not applicable
-
-
- -  The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- -  Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- -  Because test methods applicable to solid substances are not available, the classification is not possible. Besides, one with more than 0.05% of maleic anhydride is classified in Class 8, PG III (UN2698) in UNRTDG.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- -  Based on the LD50 value of 5,410 mg/kg for rats (CICAD 75 (2009), HSDB (Access on May 2016)), the substance was classified as "Not classified."
1 Acute toxicity (Dermal) Classification not possible
-
-
- -  Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- -  Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- -  Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
 It is described that acid anhydrides are hydrated to acids and cause irritation, reddening, corneal damage, caustic dermatitis, and burns (CICAD 75 (2009), and that this substance is a corrosive irritant to the skin (HSDB (Access on May 2016)). However, the former information (CICAD) is limited to sweating skin, and other organizations have not determined this substance to be skin corrosive (GESTIS (Access on May 2016), ICSC (2001)). Therefore, the substance was classified in Category 2.
 Besides, results of "not irritating" in a semi-occlusive test (OECD TG 404) for 4 hours using rabbits were reported (ECHA (Access on August 2016)). However, this information was not adopted as the evidence of classification because this information was not from the listed information sources available for the GHS classification guidance of the Japanese government. The classification was changed along with the revision of information sources. Information source used in the previous classification was not available.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
 Based on the information that this substance is a corrosive irritant to the eyes (HSDB (Access on June 2016)), the substance was classified in Category 1. Besides, this substance is classified as "H318 Eye Dam. 1" in the EU CLP classification (ECHA C&L Inventory (Access on May 2016)). Information sources of the previous classification were not available.
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501
 Based on the information that prolonged inhalation exposure may induce respiratory sensitization (HSDB (Access on June 2016)), the substance was classified in Category 1. Besides, this substance is classified as "H334 Resp. Sens. 1" in the EU CLP classification (ECHA C&L Inventory (Access on May 2016)). The classification was changed along with the revision of information sources.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
 Based on the information that repeated exposure may cause skin sensitization (HSDB (Access on June 2016)), the substance was classified in Category 1. Besides, it was reported that the substance was sensitizing as a result of a maximization test (OECD TG 406) using guinea pigs. In addition, this substance is classified as "H317 Skin. Sens. 1" in the EU CLP classification (ECHA C&L Inventory (Access on May 2016)).
5 Germ cell mutagenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
 There is no data for in vivo, and as for in vitro, a bacterial reverse mutation test was negative (HSDB (Access on May 2016)).
6 Carcinogenicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- -  Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
 In humans, the irritative symptoms (itching, lacrimation, sneezing, rhinorrhoea, coughs, and dyspnoea) begin immediately following exposure to high concentrations of dusts or vapors of cyclic acid anhydrides (CICAD 75 (2009)). Moreover, symptoms such as coughs, sore throat, wheezing, shortness of breath, etc. are caused by inhalation of this substance (HSDB (Access on May 2016)). Therefore, the substance was classified in Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- -  Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data available.


NOTE:
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted.
* Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement.
Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.
* Codes assigned to each of the hazard statements and codes for each of the precautionary statement are
based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations.

To GHS Information