GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 50926-11-9 |
| Chemical Name | Indium tin oxide |
| Substance ID | H28-B-010, C-013B |
| Classification year (FY) | FY2016 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2006 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
| 3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
| 5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
| 6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (HSDB (Access on May 2016)) . |
| 8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (HSDB (Access on May 2016)) . |
| 11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (HSDB (Access on May 2016)) . |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (HSDB (Access on May 2016)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Not classified |
- |
- | - | The LD50 value of > 10,000 mg/kg (PATTY (6th, 2012)) for rats is reported for indium oxide. Indium tin oxide is a mixture of indium oxide and tin oxide, and LD50 values of these compounds are both 2,000 mg/kg or above, therefore, this substance was classified as "Not classified." |
| 1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 2 |
 Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
Based on the description that this substance may cause severe irritation to the skin (HSDB (Access on June 2016)), this substance was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Based on the description that this substance may cause severe irritation to the eyes (HSDB (Access on June 2016)), this substance was classified in Category 2A. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. As for in vivo, in the intratracheal administration test of this substance (ITO particles) on rats, a significant increase in micronuclei frequency was observed. However, as for the in vitro test, an increase in the micronuclei frequency in the alveolar epithelial cells by this substance (ITO particles) was not observed, and therefore, it is evaluated that the result of the in vivo test is due to a secondary genotoxic mechanism (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), HSDB (Access on May 2016)). There is no other information. |
| 6 | Carcinogenicity | Category 1B |
 Danger |
H350 |
P308+P313
P201 P202 P280 P405 P501 |
There is no information on carcinogenicity to humans. As for experimental animals, in a carcinogenicity study using rats or mice exposed by inhalation to indium tin oxide (ITO) containing 90.06% of indium oxide and 9.74% of tin oxide at a concentration of 0.01 - 0.1 mg/m3 for 2 years (26 weeks only for rats in a high concentration group due to lung injury), neoplastic change was not observed in the mice, but as for the rats, increase in the incidences of pulmonary tumors including bronchiolar-alveolar adenomas and carcinomas were observed in both sexes (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). As for classifications by other organizations, the Japan Society for Occupational Health has classified hardly soluble inorganic indium compounds in Group 2A (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2015)). Therefore, this substance was classified in Category 1B for this hazard class. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. Besides, it is described in Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013) that indium irritates the respiratory tract, but it was quoted from ICSC, and the original literature could not be confirmed. Also, it is not clear whether the descriptions on only metallic indium or a description of indium compounds in general. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
As for humans, as a case report, there is a report of interstitial pneumonia in workers involved in grinding process of indium tin compounds (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), OEL Documentations (Japan Society For Occupational Health (JSOH), 2007)). In Japan, there are case reports of interstitial pneumonia and fibrosis in workers at an indium tin oxide (ITO) production/processing factory, indium recycling factory, indium oxide manufacturing factory, and investigation report indicating an increase in KL-6 value, SP-D value and SP-A value which are indicators of interstitial pneumonia. Also, it has been revealed that lung disease, mainly interstitial pneumonia occurs due to exposure to ITO or indium oxide. Also, there are case reports that alveolar proteinosis occurs in workers at ITO manufacturing plants in the United States as well (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013)). As for experimental animals, in a 13-week study using rats exposed by inhalation, effects on the lungs (pulmonary alveolar proteinosis, granuloma of the lymph nodes of the lung, hyperplasia of the alveolar epithelium, etc.) were observed within the range of Category 1. In addition, in a 104-week inhalation exposure study, bronchiolar/alveolar hyperplasia, fibrosis of the alveolar wall in the lung, pleural thickening, granuloma of the para-bronchial lymphoid tissue and granulomas in the mediastinal lymph nodes, etc. were observed in the range of Category 1. In a 13-week study using mice exposed by inhalation, in addition to the influence on the lung (alveolar proteinosis, infiltration of inflammatory cells, hyperplasia of mediastinal lymph nodes, etc.), increases in red blood cell count, hemoglobin concentration, and hematocrit value and extramedullary hematopoiesis of the spleen, etc. were observed at within the range of Category 1. Moreover, in a 104-week study exposed by inhalation, pleural thickening, hyperplasia of mediastinal lymph nodes, hyperplasia of para-bronchial lymph tissue, etc. were observed as effects on the lungs within the range of Category 1 (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013). Of the above, hematological findings and effects on the hematopoietic system were not adopted as evidence of classification because it is considered that they may be adaptive response to lack of oxygen due to respiratory effects. Also, in the previous classification, in ACGIH (7th, 2001), based on the description that "For indium and its compounds, TLV-TWA is set up by the influence to the skeleton and gastrointestinal system and hazardous properties especially by the inhalation to the lungs," etc., skeletal and digestive system as well as respiratory organs were determined as target organs. However, this is based on a preliminary investigation on exposure to indium compounds by the EPA, and because it is a preliminary survey, and its reliability is considered to be low due to no information other than symptom names based on complaints, etc., it was not adopted as evidence of the classification. Therefore, this substance was classified in Category 1 (respiratory organs). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
| Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
| 11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. |
NOTE:
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* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |